Inulin Diet Intervention on Chemopreventive and Inflammatory Markers in Tumorigenesis of Colorectal Cancer

The aim of this experiment was to investigate the infl uence of inulin administration on chemopreventive and inflammatory markers in dimethylhydrazine induced colorectal cancer development in rats. A group of 30 Sprague-Dawley rats was divided into a control group (CG), a group with dimethylhydrazin...

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Autores principales:	Emília Hijová, Viktoria Szabadosova, Jana Štofilová, Rastislav Salaj, Alojz Bomba
Formato:	article
Lenguaje:	EN
Publicado:	Sciendo 2014
Materias:	colon cancer sprague-dawley rats inulin chemoprevention inflammation Veterinary medicine SF600-1100
Acceso en línea:	https://doaj.org/article/1c41ad777e3a4eb99c52193815bb0298
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spelling	oai:doaj.org-article:1c41ad777e3a4eb99c52193815bb02982021-11-17T21:27:52ZInulin Diet Intervention on Chemopreventive and Inflammatory Markers in Tumorigenesis of Colorectal Cancer1820-744810.2478/acve-2014-0048https://doaj.org/article/1c41ad777e3a4eb99c52193815bb02982014-12-01T00:00:00Zhttps://doi.org/10.2478/acve-2014-0048https://doaj.org/toc/1820-7448The aim of this experiment was to investigate the infl uence of inulin administration on chemopreventive and inflammatory markers in dimethylhydrazine induced colorectal cancer development in rats. A group of 30 Sprague-Dawley rats was divided into a control group (CG), a group with dimethylhydrazine (DMH), and a group given dimethylhydrazine combined with the prebiotic (DMH+PRE). Dimethylhydrazine injection significantly (p<0.001) elevated the immunoreactivity chemopreventive markers COX-2, NFκB, iNOS, elevated serum and jejunal mucosa levels of proinfl ammatory cytokine IL-2, and decreased serum and jejunal mucosa levels of regulatory cytokine IL-10. Inulin diet intervention significantly suppressed immunoreactivity of COX- 2, NFκB, iNOS positive cells in the tunica mucosae and tela submucosae of rat colon tissue, increased levels of IL-2 and decreased levels of IL-10. By determining the chemopreventive markers COX-2, iNOS and NFkB, which can be characterized as inflammatory markers, we confirmed the presence of inflammation in the colon as the number of COX-2, NFkB and iNOS immunoreactive cells was significantly higher after DMH application than in the control group. These findings indicate that dietary intake of inulin suppressed the expression of the observed markers, which play an important role in carcinogenesis and inflammation, which predispose the use of inulin in the prevention or treatment of human chronic diseases and its use as a nutritional supplement in veterinary medicine.Emília HijováViktoria SzabadosovaJana ŠtofilováRastislav SalajAlojz BombaSciendoarticlecolon cancersprague-dawley ratsinulinchemopreventioninflammationVeterinary medicineSF600-1100ENActa Veterinaria, Vol 64, Iss 4, Pp 519-525 (2014)
institution	DOAJ
collection	DOAJ
language	EN
topic	colon cancer sprague-dawley rats inulin chemoprevention inflammation Veterinary medicine SF600-1100
spellingShingle	colon cancer sprague-dawley rats inulin chemoprevention inflammation Veterinary medicine SF600-1100 Emília Hijová Viktoria Szabadosova Jana Štofilová Rastislav Salaj Alojz Bomba Inulin Diet Intervention on Chemopreventive and Inflammatory Markers in Tumorigenesis of Colorectal Cancer
description	The aim of this experiment was to investigate the infl uence of inulin administration on chemopreventive and inflammatory markers in dimethylhydrazine induced colorectal cancer development in rats. A group of 30 Sprague-Dawley rats was divided into a control group (CG), a group with dimethylhydrazine (DMH), and a group given dimethylhydrazine combined with the prebiotic (DMH+PRE). Dimethylhydrazine injection significantly (p<0.001) elevated the immunoreactivity chemopreventive markers COX-2, NFκB, iNOS, elevated serum and jejunal mucosa levels of proinfl ammatory cytokine IL-2, and decreased serum and jejunal mucosa levels of regulatory cytokine IL-10. Inulin diet intervention significantly suppressed immunoreactivity of COX- 2, NFκB, iNOS positive cells in the tunica mucosae and tela submucosae of rat colon tissue, increased levels of IL-2 and decreased levels of IL-10. By determining the chemopreventive markers COX-2, iNOS and NFkB, which can be characterized as inflammatory markers, we confirmed the presence of inflammation in the colon as the number of COX-2, NFkB and iNOS immunoreactive cells was significantly higher after DMH application than in the control group. These findings indicate that dietary intake of inulin suppressed the expression of the observed markers, which play an important role in carcinogenesis and inflammation, which predispose the use of inulin in the prevention or treatment of human chronic diseases and its use as a nutritional supplement in veterinary medicine.
format	article
author	Emília Hijová Viktoria Szabadosova Jana Štofilová Rastislav Salaj Alojz Bomba
author_facet	Emília Hijová Viktoria Szabadosova Jana Štofilová Rastislav Salaj Alojz Bomba
author_sort	Emília Hijová
title	Inulin Diet Intervention on Chemopreventive and Inflammatory Markers in Tumorigenesis of Colorectal Cancer
title_short	Inulin Diet Intervention on Chemopreventive and Inflammatory Markers in Tumorigenesis of Colorectal Cancer
title_full	Inulin Diet Intervention on Chemopreventive and Inflammatory Markers in Tumorigenesis of Colorectal Cancer
title_fullStr	Inulin Diet Intervention on Chemopreventive and Inflammatory Markers in Tumorigenesis of Colorectal Cancer
title_full_unstemmed	Inulin Diet Intervention on Chemopreventive and Inflammatory Markers in Tumorigenesis of Colorectal Cancer
title_sort	inulin diet intervention on chemopreventive and inflammatory markers in tumorigenesis of colorectal cancer
publisher	Sciendo
publishDate	2014
url	https://doaj.org/article/1c41ad777e3a4eb99c52193815bb0298
work_keys_str_mv	AT emiliahijova inulindietinterventiononchemopreventiveandinflammatorymarkersintumorigenesisofcolorectalcancer AT viktoriaszabadosova inulindietinterventiononchemopreventiveandinflammatorymarkersintumorigenesisofcolorectalcancer AT janastofilova inulindietinterventiononchemopreventiveandinflammatorymarkersintumorigenesisofcolorectalcancer AT rastislavsalaj inulindietinterventiononchemopreventiveandinflammatorymarkersintumorigenesisofcolorectalcancer AT alojzbomba inulindietinterventiononchemopreventiveandinflammatorymarkersintumorigenesisofcolorectalcancer
_version_	1718425271494770688

Inulin Diet Intervention on Chemopreventive and Inflammatory Markers in Tumorigenesis of Colorectal Cancer

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