Selective and noncovalent targeting of RAS mutants for inhibition and degradation

Most oncogenic RAS mutants remain undruggable. Here, the authors developed monobodies that selectively recognize the active state of KRAS(G12V) and KRAS(G12C) and demonstrated their utility in inhibiting RAS functions through inhibition and degradation.

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Autores principales:	Kai Wen Teng, Steven T. Tsai, Takamitsu Hattori, Carmine Fedele, Akiko Koide, Chao Yang, Xuben Hou, Yingkai Zhang, Benjamin G. Neel, John P. O’Bryan, Shohei Koide
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/1c4337f6a3694e9b96918c1bb0fcb1f7
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spelling	oai:doaj.org-article:1c4337f6a3694e9b96918c1bb0fcb1f72021-12-02T15:36:29ZSelective and noncovalent targeting of RAS mutants for inhibition and degradation10.1038/s41467-021-22969-52041-1723https://doaj.org/article/1c4337f6a3694e9b96918c1bb0fcb1f72021-05-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-22969-5https://doaj.org/toc/2041-1723Most oncogenic RAS mutants remain undruggable. Here, the authors developed monobodies that selectively recognize the active state of KRAS(G12V) and KRAS(G12C) and demonstrated their utility in inhibiting RAS functions through inhibition and degradation.Kai Wen TengSteven T. TsaiTakamitsu HattoriCarmine FedeleAkiko KoideChao YangXuben HouYingkai ZhangBenjamin G. NeelJohn P. O’BryanShohei KoideNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-13 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Kai Wen Teng Steven T. Tsai Takamitsu Hattori Carmine Fedele Akiko Koide Chao Yang Xuben Hou Yingkai Zhang Benjamin G. Neel John P. O’Bryan Shohei Koide Selective and noncovalent targeting of RAS mutants for inhibition and degradation
description	Most oncogenic RAS mutants remain undruggable. Here, the authors developed monobodies that selectively recognize the active state of KRAS(G12V) and KRAS(G12C) and demonstrated their utility in inhibiting RAS functions through inhibition and degradation.
format	article
author	Kai Wen Teng Steven T. Tsai Takamitsu Hattori Carmine Fedele Akiko Koide Chao Yang Xuben Hou Yingkai Zhang Benjamin G. Neel John P. O’Bryan Shohei Koide
author_facet	Kai Wen Teng Steven T. Tsai Takamitsu Hattori Carmine Fedele Akiko Koide Chao Yang Xuben Hou Yingkai Zhang Benjamin G. Neel John P. O’Bryan Shohei Koide
author_sort	Kai Wen Teng
title	Selective and noncovalent targeting of RAS mutants for inhibition and degradation
title_short	Selective and noncovalent targeting of RAS mutants for inhibition and degradation
title_full	Selective and noncovalent targeting of RAS mutants for inhibition and degradation
title_fullStr	Selective and noncovalent targeting of RAS mutants for inhibition and degradation
title_full_unstemmed	Selective and noncovalent targeting of RAS mutants for inhibition and degradation
title_sort	selective and noncovalent targeting of ras mutants for inhibition and degradation
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/1c4337f6a3694e9b96918c1bb0fcb1f7
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Selective and noncovalent targeting of RAS mutants for inhibition and degradation

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