Minor allele of GJA1 gene polymorphism is associated with higher heart rate during atrial fibrillation

Abstract Atrial fibrillation (AF) tachycardia causes heart failure and requires more attention. The genetic background of individual heart rate (HR) variations during AF are unclear. We hypothesized that HR-associated single nucleotide polymorphisms (SNPs) reported in Genome-Wide Association Studies...

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Autores principales:	Sho Okamura, Yuko Onohara, Hidenori Ochi, Takehito Tokuyama, Naoya Hironobe, Yosaku Okubo, Yoshihiro Ikeuchi, Shunsuke Miyauchi, Kazuaki Chayama, Yasuki Kihara, Yukiko Nakano
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/1c46b2bcf808406d97ac9bb8a7fc0172
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spelling	oai:doaj.org-article:1c46b2bcf808406d97ac9bb8a7fc01722021-12-02T14:16:57ZMinor allele of GJA1 gene polymorphism is associated with higher heart rate during atrial fibrillation10.1038/s41598-021-82117-32045-2322https://doaj.org/article/1c46b2bcf808406d97ac9bb8a7fc01722021-01-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-82117-3https://doaj.org/toc/2045-2322Abstract Atrial fibrillation (AF) tachycardia causes heart failure and requires more attention. The genetic background of individual heart rate (HR) variations during AF are unclear. We hypothesized that HR-associated single nucleotide polymorphisms (SNPs) reported in Genome-Wide Association Studies (GWAS) are also associated with HR during AF. We enrolled patients with persistent AF (311 for screening and 146 for replication) who underwent AF ablation and were genotyped for the 21 h-associated SNPs reported in GWAS. The patients underwent 24-h Holter monitoring before AF ablation and electrophysiological study after AF ablation during sinus rhythm. Only the GJA1 SNP rs1015451 (T>C) was significantly associated with total HR (TT 110,643 ± 17,542 beats/day, TC 116,350 ± 19,060 beats/day, CC 122,163 ± 25,684 beats/day, P = 8.5 × 10−4). We also confirmed this significant association in the replication set. The intra-atrial conduction was faster in AF patients with the GJA1 minor allele than in those without it. Multivariate analysis revealed the presence of a GJA1 SNP rs1015451 additive model, female gender, lower left ventricular ejection fraction, and higher 1:1 atrioventricular nodal conduction were independently associated with higher HR during AF. The GJA1 SNP might be a new genetic marker for AF tachycardia.Sho OkamuraYuko OnoharaHidenori OchiTakehito TokuyamaNaoya HironobeYosaku OkuboYoshihiro IkeuchiShunsuke MiyauchiKazuaki ChayamaYasuki KiharaYukiko NakanoNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-8 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Sho Okamura Yuko Onohara Hidenori Ochi Takehito Tokuyama Naoya Hironobe Yosaku Okubo Yoshihiro Ikeuchi Shunsuke Miyauchi Kazuaki Chayama Yasuki Kihara Yukiko Nakano Minor allele of GJA1 gene polymorphism is associated with higher heart rate during atrial fibrillation
description	Abstract Atrial fibrillation (AF) tachycardia causes heart failure and requires more attention. The genetic background of individual heart rate (HR) variations during AF are unclear. We hypothesized that HR-associated single nucleotide polymorphisms (SNPs) reported in Genome-Wide Association Studies (GWAS) are also associated with HR during AF. We enrolled patients with persistent AF (311 for screening and 146 for replication) who underwent AF ablation and were genotyped for the 21 h-associated SNPs reported in GWAS. The patients underwent 24-h Holter monitoring before AF ablation and electrophysiological study after AF ablation during sinus rhythm. Only the GJA1 SNP rs1015451 (T>C) was significantly associated with total HR (TT 110,643 ± 17,542 beats/day, TC 116,350 ± 19,060 beats/day, CC 122,163 ± 25,684 beats/day, P = 8.5 × 10−4). We also confirmed this significant association in the replication set. The intra-atrial conduction was faster in AF patients with the GJA1 minor allele than in those without it. Multivariate analysis revealed the presence of a GJA1 SNP rs1015451 additive model, female gender, lower left ventricular ejection fraction, and higher 1:1 atrioventricular nodal conduction were independently associated with higher HR during AF. The GJA1 SNP might be a new genetic marker for AF tachycardia.
format	article
author	Sho Okamura Yuko Onohara Hidenori Ochi Takehito Tokuyama Naoya Hironobe Yosaku Okubo Yoshihiro Ikeuchi Shunsuke Miyauchi Kazuaki Chayama Yasuki Kihara Yukiko Nakano
author_facet	Sho Okamura Yuko Onohara Hidenori Ochi Takehito Tokuyama Naoya Hironobe Yosaku Okubo Yoshihiro Ikeuchi Shunsuke Miyauchi Kazuaki Chayama Yasuki Kihara Yukiko Nakano
author_sort	Sho Okamura
title	Minor allele of GJA1 gene polymorphism is associated with higher heart rate during atrial fibrillation
title_short	Minor allele of GJA1 gene polymorphism is associated with higher heart rate during atrial fibrillation
title_full	Minor allele of GJA1 gene polymorphism is associated with higher heart rate during atrial fibrillation
title_fullStr	Minor allele of GJA1 gene polymorphism is associated with higher heart rate during atrial fibrillation
title_full_unstemmed	Minor allele of GJA1 gene polymorphism is associated with higher heart rate during atrial fibrillation
title_sort	minor allele of gja1 gene polymorphism is associated with higher heart rate during atrial fibrillation
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/1c46b2bcf808406d97ac9bb8a7fc0172
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Minor allele of GJA1 gene polymorphism is associated with higher heart rate during atrial fibrillation

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