Deformation and rupture of microcapsules flowing through constricted capillary

Abstract The dynamics of deformable microcapsules flowing through constricted channels is relevant in target delivery of chemicals in physiological systems, porous media, microfluidic medical diagnostic devices and many other applications. In some situations, the microcapsules need to sustain the st...

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Autores principales:	Bruna C. Leopércio, Mariano Michelon, Marcio S. Carvalho
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/1c47d84055f74eb6ba6393389df06183
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spelling	oai:doaj.org-article:1c47d84055f74eb6ba6393389df061832021-12-02T18:15:33ZDeformation and rupture of microcapsules flowing through constricted capillary10.1038/s41598-021-86833-82045-2322https://doaj.org/article/1c47d84055f74eb6ba6393389df061832021-04-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-86833-8https://doaj.org/toc/2045-2322Abstract The dynamics of deformable microcapsules flowing through constricted channels is relevant in target delivery of chemicals in physiological systems, porous media, microfluidic medical diagnostic devices and many other applications. In some situations, the microcapsules need to sustain the stress they are subjected to as they flow through constricted channels and in others, the stress may be the rupture trigger used to release the internal content. We experimentally investigate the flow of monodispersed gellan gum microcapsules through a constricted capillary tube by measuring the evolution of the pressure difference and flow visualization. The maximum pressure difference and capsule deformation is obtained for capsules with different diameter and shell thickness. We map the conditions, e.g. diameter and shell thickness, at which the capsule membrane ruptures during the flow, releasing its internal phase.Bruna C. LeopércioMariano MichelonMarcio S. CarvalhoNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-12 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Bruna C. Leopércio Mariano Michelon Marcio S. Carvalho Deformation and rupture of microcapsules flowing through constricted capillary
description	Abstract The dynamics of deformable microcapsules flowing through constricted channels is relevant in target delivery of chemicals in physiological systems, porous media, microfluidic medical diagnostic devices and many other applications. In some situations, the microcapsules need to sustain the stress they are subjected to as they flow through constricted channels and in others, the stress may be the rupture trigger used to release the internal content. We experimentally investigate the flow of monodispersed gellan gum microcapsules through a constricted capillary tube by measuring the evolution of the pressure difference and flow visualization. The maximum pressure difference and capsule deformation is obtained for capsules with different diameter and shell thickness. We map the conditions, e.g. diameter and shell thickness, at which the capsule membrane ruptures during the flow, releasing its internal phase.
format	article
author	Bruna C. Leopércio Mariano Michelon Marcio S. Carvalho
author_facet	Bruna C. Leopércio Mariano Michelon Marcio S. Carvalho
author_sort	Bruna C. Leopércio
title	Deformation and rupture of microcapsules flowing through constricted capillary
title_short	Deformation and rupture of microcapsules flowing through constricted capillary
title_full	Deformation and rupture of microcapsules flowing through constricted capillary
title_fullStr	Deformation and rupture of microcapsules flowing through constricted capillary
title_full_unstemmed	Deformation and rupture of microcapsules flowing through constricted capillary
title_sort	deformation and rupture of microcapsules flowing through constricted capillary
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/1c47d84055f74eb6ba6393389df06183
work_keys_str_mv	AT brunacleopercio deformationandruptureofmicrocapsulesflowingthroughconstrictedcapillary AT marianomichelon deformationandruptureofmicrocapsulesflowingthroughconstrictedcapillary AT marcioscarvalho deformationandruptureofmicrocapsulesflowingthroughconstrictedcapillary
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Deformation and rupture of microcapsules flowing through constricted capillary

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