Motor neurons control blood vessel patterning in the developing spinal cord

The guidance cues regulating blood vessel patterning in the central nervous system remain unclear. Here, the authors show in mice and chicken developing spinal cord that motor neurons control blood vessel patterning by an autocrine mechanism titrating VEGF via the expression of its trapping receptor...

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Autores principales:	Patricia Himmels, Isidora Paredes, Heike Adler, Andromachi Karakatsani, Robert Luck, Hugo H. Marti, Olga Ermakova, Eugen Rempel, Esther T. Stoeckli, Carmen Ruiz de Almodóvar
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/1c485bbbb8e44bb3a721507f6d42678e
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spelling	oai:doaj.org-article:1c485bbbb8e44bb3a721507f6d42678e2021-12-02T17:06:27ZMotor neurons control blood vessel patterning in the developing spinal cord10.1038/ncomms145832041-1723https://doaj.org/article/1c485bbbb8e44bb3a721507f6d42678e2017-03-01T00:00:00Zhttps://doi.org/10.1038/ncomms14583https://doaj.org/toc/2041-1723The guidance cues regulating blood vessel patterning in the central nervous system remain unclear. Here, the authors show in mice and chicken developing spinal cord that motor neurons control blood vessel patterning by an autocrine mechanism titrating VEGF via the expression of its trapping receptor sFlt1.Patricia HimmelsIsidora ParedesHeike AdlerAndromachi KarakatsaniRobert LuckHugo H. MartiOlga ErmakovaEugen RempelEsther T. StoeckliCarmen Ruiz de AlmodóvarNature PortfolioarticleScienceQENNature Communications, Vol 8, Iss 1, Pp 1-16 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Patricia Himmels Isidora Paredes Heike Adler Andromachi Karakatsani Robert Luck Hugo H. Marti Olga Ermakova Eugen Rempel Esther T. Stoeckli Carmen Ruiz de Almodóvar Motor neurons control blood vessel patterning in the developing spinal cord
description	The guidance cues regulating blood vessel patterning in the central nervous system remain unclear. Here, the authors show in mice and chicken developing spinal cord that motor neurons control blood vessel patterning by an autocrine mechanism titrating VEGF via the expression of its trapping receptor sFlt1.
format	article
author	Patricia Himmels Isidora Paredes Heike Adler Andromachi Karakatsani Robert Luck Hugo H. Marti Olga Ermakova Eugen Rempel Esther T. Stoeckli Carmen Ruiz de Almodóvar
author_facet	Patricia Himmels Isidora Paredes Heike Adler Andromachi Karakatsani Robert Luck Hugo H. Marti Olga Ermakova Eugen Rempel Esther T. Stoeckli Carmen Ruiz de Almodóvar
author_sort	Patricia Himmels
title	Motor neurons control blood vessel patterning in the developing spinal cord
title_short	Motor neurons control blood vessel patterning in the developing spinal cord
title_full	Motor neurons control blood vessel patterning in the developing spinal cord
title_fullStr	Motor neurons control blood vessel patterning in the developing spinal cord
title_full_unstemmed	Motor neurons control blood vessel patterning in the developing spinal cord
title_sort	motor neurons control blood vessel patterning in the developing spinal cord
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/1c485bbbb8e44bb3a721507f6d42678e
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Motor neurons control blood vessel patterning in the developing spinal cord

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