Modelling genetic mosaicism of neurodevelopmental disorders in vivo by a Cre-amplifying fluorescent reporter

Genetic mosaicism is frequently present in monogenic diseases of the central nervous system. Here the authors design a dual-colour reporter system that can be used to tune the degree of mosaicism in mouse models.

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Autores principales:	Francesco Trovato, Riccardo Parra, Enrico Pracucci, Silvia Landi, Olga Cozzolino, Gabriele Nardi, Federica Cruciani, Vinoshene Pillai, Laura Mosti, Andrzej W. Cwetsch, Laura Cancedda, Laura Gritti, Carlo Sala, Chiara Verpelli, Andrea Maset, Claudia Lodovichi, Gian Michele Ratto
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/1c4e916eb6864c37acafbefd423dd53f
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spelling	oai:doaj.org-article:1c4e916eb6864c37acafbefd423dd53f2021-12-02T15:37:20ZModelling genetic mosaicism of neurodevelopmental disorders in vivo by a Cre-amplifying fluorescent reporter10.1038/s41467-020-19864-w2041-1723https://doaj.org/article/1c4e916eb6864c37acafbefd423dd53f2020-12-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-19864-whttps://doaj.org/toc/2041-1723Genetic mosaicism is frequently present in monogenic diseases of the central nervous system. Here the authors design a dual-colour reporter system that can be used to tune the degree of mosaicism in mouse models.Francesco TrovatoRiccardo ParraEnrico PracucciSilvia LandiOlga CozzolinoGabriele NardiFederica CrucianiVinoshene PillaiLaura MostiAndrzej W. CwetschLaura CanceddaLaura GrittiCarlo SalaChiara VerpelliAndrea MasetClaudia LodovichiGian Michele RattoNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-13 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Francesco Trovato Riccardo Parra Enrico Pracucci Silvia Landi Olga Cozzolino Gabriele Nardi Federica Cruciani Vinoshene Pillai Laura Mosti Andrzej W. Cwetsch Laura Cancedda Laura Gritti Carlo Sala Chiara Verpelli Andrea Maset Claudia Lodovichi Gian Michele Ratto Modelling genetic mosaicism of neurodevelopmental disorders in vivo by a Cre-amplifying fluorescent reporter
description	Genetic mosaicism is frequently present in monogenic diseases of the central nervous system. Here the authors design a dual-colour reporter system that can be used to tune the degree of mosaicism in mouse models.
format	article
author	Francesco Trovato Riccardo Parra Enrico Pracucci Silvia Landi Olga Cozzolino Gabriele Nardi Federica Cruciani Vinoshene Pillai Laura Mosti Andrzej W. Cwetsch Laura Cancedda Laura Gritti Carlo Sala Chiara Verpelli Andrea Maset Claudia Lodovichi Gian Michele Ratto
author_facet	Francesco Trovato Riccardo Parra Enrico Pracucci Silvia Landi Olga Cozzolino Gabriele Nardi Federica Cruciani Vinoshene Pillai Laura Mosti Andrzej W. Cwetsch Laura Cancedda Laura Gritti Carlo Sala Chiara Verpelli Andrea Maset Claudia Lodovichi Gian Michele Ratto
author_sort	Francesco Trovato
title	Modelling genetic mosaicism of neurodevelopmental disorders in vivo by a Cre-amplifying fluorescent reporter
title_short	Modelling genetic mosaicism of neurodevelopmental disorders in vivo by a Cre-amplifying fluorescent reporter
title_full	Modelling genetic mosaicism of neurodevelopmental disorders in vivo by a Cre-amplifying fluorescent reporter
title_fullStr	Modelling genetic mosaicism of neurodevelopmental disorders in vivo by a Cre-amplifying fluorescent reporter
title_full_unstemmed	Modelling genetic mosaicism of neurodevelopmental disorders in vivo by a Cre-amplifying fluorescent reporter
title_sort	modelling genetic mosaicism of neurodevelopmental disorders in vivo by a cre-amplifying fluorescent reporter
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/1c4e916eb6864c37acafbefd423dd53f
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Modelling genetic mosaicism of neurodevelopmental disorders in vivo by a Cre-amplifying fluorescent reporter

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