Circulating bile acids concentration is predictive of coronary artery disease in human
Abstract Synthetized by the liver and metabolized by the gut microbiota, BA are involved in metabolic liver diseases that are associated with cardiovascular disorders. Animal models of atheroma documented a powerful anti-atherosclerotic effect of bile acids (BA). This prospective study examined whet...
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2021
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oai:doaj.org-article:1c4ea355bf004c9ebc1162d31405978c2021-11-28T12:21:39ZCirculating bile acids concentration is predictive of coronary artery disease in human10.1038/s41598-021-02144-y2045-2322https://doaj.org/article/1c4ea355bf004c9ebc1162d31405978c2021-11-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-02144-yhttps://doaj.org/toc/2045-2322Abstract Synthetized by the liver and metabolized by the gut microbiota, BA are involved in metabolic liver diseases that are associated with cardiovascular disorders. Animal models of atheroma documented a powerful anti-atherosclerotic effect of bile acids (BA). This prospective study examined whether variations in circulating BA are predictive of coronary artery disease (CAD) in human. Consecutive patients undergoing coronary angiography were enrolled. Circulating and fecal BA were measured by high pressure liquid chromatography and tandem mass spectrometry. Of 406 screened patients, 80 were prospectively included and divided in two groups with (n = 45) and without (n = 35) CAD. The mean serum concentration of total BA was twice lower in patients with, versus without CAD (P = 0.005). Adjusted for gender and age, this decrease was an independent predictor of CAD. In a subgroup of 17 patients, statin therapy doubled the serum BA concentration. Decreased serum concentrations of BA were predictors of CAD in humans. A subgroup analysis showed a possible correction by statins. With respect to the anti-atherosclerotic effect of BA in animal models, and their role in human lipid metabolism, this study describe a new metabolic disturbance associated to CAD in human.Caroline Chong NguyenDenis DubocDominique RainteauHarry SokolLydie HumbertPhilippe SeksikAdèle BellinoHendy AbdoulNaïm BouazzaJean-Marc TreluyerMalika SaadiKarim WahbiHeithem SolimanBenoit CoffinAndré BadoMaude Le GallOlivier VarenneHenri DubocNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-10 (2021) |
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Medicine R Science Q Caroline Chong Nguyen Denis Duboc Dominique Rainteau Harry Sokol Lydie Humbert Philippe Seksik Adèle Bellino Hendy Abdoul Naïm Bouazza Jean-Marc Treluyer Malika Saadi Karim Wahbi Heithem Soliman Benoit Coffin André Bado Maude Le Gall Olivier Varenne Henri Duboc Circulating bile acids concentration is predictive of coronary artery disease in human |
| description |
Abstract Synthetized by the liver and metabolized by the gut microbiota, BA are involved in metabolic liver diseases that are associated with cardiovascular disorders. Animal models of atheroma documented a powerful anti-atherosclerotic effect of bile acids (BA). This prospective study examined whether variations in circulating BA are predictive of coronary artery disease (CAD) in human. Consecutive patients undergoing coronary angiography were enrolled. Circulating and fecal BA were measured by high pressure liquid chromatography and tandem mass spectrometry. Of 406 screened patients, 80 were prospectively included and divided in two groups with (n = 45) and without (n = 35) CAD. The mean serum concentration of total BA was twice lower in patients with, versus without CAD (P = 0.005). Adjusted for gender and age, this decrease was an independent predictor of CAD. In a subgroup of 17 patients, statin therapy doubled the serum BA concentration. Decreased serum concentrations of BA were predictors of CAD in humans. A subgroup analysis showed a possible correction by statins. With respect to the anti-atherosclerotic effect of BA in animal models, and their role in human lipid metabolism, this study describe a new metabolic disturbance associated to CAD in human. |
| format |
article |
| author |
Caroline Chong Nguyen Denis Duboc Dominique Rainteau Harry Sokol Lydie Humbert Philippe Seksik Adèle Bellino Hendy Abdoul Naïm Bouazza Jean-Marc Treluyer Malika Saadi Karim Wahbi Heithem Soliman Benoit Coffin André Bado Maude Le Gall Olivier Varenne Henri Duboc |
| author_facet |
Caroline Chong Nguyen Denis Duboc Dominique Rainteau Harry Sokol Lydie Humbert Philippe Seksik Adèle Bellino Hendy Abdoul Naïm Bouazza Jean-Marc Treluyer Malika Saadi Karim Wahbi Heithem Soliman Benoit Coffin André Bado Maude Le Gall Olivier Varenne Henri Duboc |
| author_sort |
Caroline Chong Nguyen |
| title |
Circulating bile acids concentration is predictive of coronary artery disease in human |
| title_short |
Circulating bile acids concentration is predictive of coronary artery disease in human |
| title_full |
Circulating bile acids concentration is predictive of coronary artery disease in human |
| title_fullStr |
Circulating bile acids concentration is predictive of coronary artery disease in human |
| title_full_unstemmed |
Circulating bile acids concentration is predictive of coronary artery disease in human |
| title_sort |
circulating bile acids concentration is predictive of coronary artery disease in human |
| publisher |
Nature Portfolio |
| publishDate |
2021 |
| url |
https://doaj.org/article/1c4ea355bf004c9ebc1162d31405978c |
| work_keys_str_mv |
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