Abnormalities in alternative splicing of angiogenesis-related genes and their role in HIV-related cancers

Nonkululeko N Mthembu,1 Zukile Mbita,2 Rodney Hull,1 Zodwa Dlamini1 1Research, Innovation and Engagements, Mangosuthu University of Technology, Durban, 2Department of Biochemistry, Microbiology and Biotechnology, University of Limpopo, Sovenga, South Africa Abstract: Alternative splicing of mRNA lea...

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Autores principales:	Mthembu NN, Mbita Z, Hull R, Dlamini Z
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2017
Materias:	Alternative splicing Angiogenesis HIV/AIDS-related cancers Immunologic diseases. Allergy RC581-607
Acceso en línea:	https://doaj.org/article/1c4fde007b074ae2bfa946a81a6e5340
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spelling	oai:doaj.org-article:1c4fde007b074ae2bfa946a81a6e53402021-12-02T01:02:09ZAbnormalities in alternative splicing of angiogenesis-related genes and their role in HIV-related cancers1179-1373https://doaj.org/article/1c4fde007b074ae2bfa946a81a6e53402017-03-01T00:00:00Zhttps://www.dovepress.com/abnormalities-in-alternative-splicing-of-angiogenesis-related-genes-an-peer-reviewed-article-HIVhttps://doaj.org/toc/1179-1373Nonkululeko N Mthembu,1 Zukile Mbita,2 Rodney Hull,1 Zodwa Dlamini1 1Research, Innovation and Engagements, Mangosuthu University of Technology, Durban, 2Department of Biochemistry, Microbiology and Biotechnology, University of Limpopo, Sovenga, South Africa Abstract: Alternative splicing of mRNA leads to an increase in proteome biodiversity by allowing the generation of multiple mRNAs, coding for multiple protein isoforms of various structural and functional properties from a single primary pre-mRNA transcript. The protein isoforms produced are tightly regulated in normal development but are mostly deregulated in various cancers. In HIV-infected individuals with AIDS, there is an increase in aberrant alternative splicing, resulting in an increase in HIV/AIDS-related cancers, such as Kaposi’s sarcoma, non-Hodgkin’s lymphoma, and cervical cancer. This aberrant splicing leads to abnormal production of protein and is caused by mutations in cis-acting elements or trans-acting factors in angiogenesis-related genes. Restoring the normal regulation of alternative splicing of angiogenic genes would alter the expression of protein isoforms and may confer normal cell physiology in patients with these cancers. This review highlights the abnormalities in alternative splicing of angiogenesis-related genes and their implication in HIV/AIDS-related cancers. This allows us to gain an insight into the pathogenesis of HIV/AIDS-related cancer and in turn elucidate the therapeutic potential of alternatively spliced genes in HIV/AIDS-related malignancies. Keywords: vascular endothelial growth factor, oncogenic viruses, hypoxia induced factor 1, Kaposi’s sarcoma, non-Hodgkin’s lymphoma, therapies targeting alternative splicingMthembu NNMbita ZHull RDlamini ZDove Medical PressarticleAlternative splicingAngiogenesisHIV/AIDS-related cancersImmunologic diseases. AllergyRC581-607ENHIV/AIDS: Research and Palliative Care, Vol Volume 9, Pp 77-93 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Alternative splicing Angiogenesis HIV/AIDS-related cancers Immunologic diseases. Allergy RC581-607
spellingShingle	Alternative splicing Angiogenesis HIV/AIDS-related cancers Immunologic diseases. Allergy RC581-607 Mthembu NN Mbita Z Hull R Dlamini Z Abnormalities in alternative splicing of angiogenesis-related genes and their role in HIV-related cancers
description	Nonkululeko N Mthembu,1 Zukile Mbita,2 Rodney Hull,1 Zodwa Dlamini1 1Research, Innovation and Engagements, Mangosuthu University of Technology, Durban, 2Department of Biochemistry, Microbiology and Biotechnology, University of Limpopo, Sovenga, South Africa Abstract: Alternative splicing of mRNA leads to an increase in proteome biodiversity by allowing the generation of multiple mRNAs, coding for multiple protein isoforms of various structural and functional properties from a single primary pre-mRNA transcript. The protein isoforms produced are tightly regulated in normal development but are mostly deregulated in various cancers. In HIV-infected individuals with AIDS, there is an increase in aberrant alternative splicing, resulting in an increase in HIV/AIDS-related cancers, such as Kaposi’s sarcoma, non-Hodgkin’s lymphoma, and cervical cancer. This aberrant splicing leads to abnormal production of protein and is caused by mutations in cis-acting elements or trans-acting factors in angiogenesis-related genes. Restoring the normal regulation of alternative splicing of angiogenic genes would alter the expression of protein isoforms and may confer normal cell physiology in patients with these cancers. This review highlights the abnormalities in alternative splicing of angiogenesis-related genes and their implication in HIV/AIDS-related cancers. This allows us to gain an insight into the pathogenesis of HIV/AIDS-related cancer and in turn elucidate the therapeutic potential of alternatively spliced genes in HIV/AIDS-related malignancies. Keywords: vascular endothelial growth factor, oncogenic viruses, hypoxia induced factor 1, Kaposi’s sarcoma, non-Hodgkin’s lymphoma, therapies targeting alternative splicing
format	article
author	Mthembu NN Mbita Z Hull R Dlamini Z
author_facet	Mthembu NN Mbita Z Hull R Dlamini Z
author_sort	Mthembu NN
title	Abnormalities in alternative splicing of angiogenesis-related genes and their role in HIV-related cancers
title_short	Abnormalities in alternative splicing of angiogenesis-related genes and their role in HIV-related cancers
title_full	Abnormalities in alternative splicing of angiogenesis-related genes and their role in HIV-related cancers
title_fullStr	Abnormalities in alternative splicing of angiogenesis-related genes and their role in HIV-related cancers
title_full_unstemmed	Abnormalities in alternative splicing of angiogenesis-related genes and their role in HIV-related cancers
title_sort	abnormalities in alternative splicing of angiogenesis-related genes and their role in hiv-related cancers
publisher	Dove Medical Press
publishDate	2017
url	https://doaj.org/article/1c4fde007b074ae2bfa946a81a6e5340
work_keys_str_mv	AT mthembunn abnormalitiesinalternativesplicingofangiogenesisrelatedgenesandtheirroleinhivrelatedcancers AT mbitaz abnormalitiesinalternativesplicingofangiogenesisrelatedgenesandtheirroleinhivrelatedcancers AT hullr abnormalitiesinalternativesplicingofangiogenesisrelatedgenesandtheirroleinhivrelatedcancers AT dlaminiz abnormalitiesinalternativesplicingofangiogenesisrelatedgenesandtheirroleinhivrelatedcancers
_version_	1718403301853102080

Abnormalities in alternative splicing of angiogenesis-related genes and their role in HIV-related cancers

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