IMBALANCE OF IL -1β И IL -1RA CYTOKINES IN BLOOD SERUM AND BRONCHOALVEOLAR LAVAGE IN COPD PATIENTS

Abstract. The aim of present study was to determine levels of IL-1β and its inhibitor, IL-1ra in blood serum and bronchoalveolar lavage fluid (BALF) of 20 patients with COPD, depending on severity of their disease, activity of inflammatory process, bacterial and viral complication. Methods. Twenty m...

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Autores principales:	E. A. Surkova, N. A. Kuzubova, T. P. Ses, T. S. Sologub, Yu. V. Reztsova, N. V. Yakovleva, N. V. Egorova
Formato:	article
Lenguaje:	RU
Publicado:	SPb RAACI 2014
Materias:	proinflammatory cytokines antiinflammatory cytokines il-1β il-1ra copd respiratory pathogens Immunologic diseases. Allergy RC581-607
Acceso en línea:	https://doaj.org/article/1c513bcbc1284ddea6691a12e3a98182
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spelling	oai:doaj.org-article:1c513bcbc1284ddea6691a12e3a981822021-11-18T08:03:42ZIMBALANCE OF IL -1β И IL -1RA CYTOKINES IN BLOOD SERUM AND BRONCHOALVEOLAR LAVAGE IN COPD PATIENTS1563-06252313-741X10.15789/1563-0625-2006-5-6-667-672https://doaj.org/article/1c513bcbc1284ddea6691a12e3a981822014-07-01T00:00:00Zhttps://www.mimmun.ru/mimmun/article/view/557https://doaj.org/toc/1563-0625https://doaj.org/toc/2313-741XAbstract. The aim of present study was to determine levels of IL-1β and its inhibitor, IL-1ra in blood serum and bronchoalveolar lavage fluid (BALF) of 20 patients with COPD, depending on severity of their disease, activity of inflammatory process, bacterial and viral complication. Methods. Twenty male patients with COPD (stage 2 to 4) were examined. It was shown that all the patients with COPD displayed high levels of IL-1β, both in the area of inflammation, and in blood serum. The latter index was dependent on the severity of disease and activity of inflammatory process. In BALF, the contents of IL-1β in all the patients under study was significantly exceeded the normal levels of this cytokine even at the earliest stages of evolving COPD. concentration in serum was depended at stage of disease and activity of inflammatory procces. There were no differences in IL-1β concentrations in BALF of 2 - 4 stage COPD patients. IL-1ra levels in the patients’ serum were within normal levels, and tended to increase in BAL, thus causing imbalanced IL-1ra/IL-1β ratio both in the inflammatory area, as well as systemically. The maximal detection of respiratory pathogens did significantly correlate with decreased IL-1ra/ IL-1β ratio, thus confirming the data on infectious agents as a pathogenetic component in COPD.E. A. SurkovaN. A. KuzubovaT. P. SesT. S. SologubYu. V. ReztsovaN. V. YakovlevaN. V. EgorovaSPb RAACIarticleproinflammatory cytokinesantiinflammatory cytokinesil-1βil-1racopdrespiratory pathogensImmunologic diseases. AllergyRC581-607RUMedicinskaâ Immunologiâ, Vol 8, Iss 5-6, Pp 667-672 (2014)
institution	DOAJ
collection	DOAJ
language	RU
topic	proinflammatory cytokines antiinflammatory cytokines il-1β il-1ra copd respiratory pathogens Immunologic diseases. Allergy RC581-607
spellingShingle	proinflammatory cytokines antiinflammatory cytokines il-1β il-1ra copd respiratory pathogens Immunologic diseases. Allergy RC581-607 E. A. Surkova N. A. Kuzubova T. P. Ses T. S. Sologub Yu. V. Reztsova N. V. Yakovleva N. V. Egorova IMBALANCE OF IL -1β И IL -1RA CYTOKINES IN BLOOD SERUM AND BRONCHOALVEOLAR LAVAGE IN COPD PATIENTS
description	Abstract. The aim of present study was to determine levels of IL-1β and its inhibitor, IL-1ra in blood serum and bronchoalveolar lavage fluid (BALF) of 20 patients with COPD, depending on severity of their disease, activity of inflammatory process, bacterial and viral complication. Methods. Twenty male patients with COPD (stage 2 to 4) were examined. It was shown that all the patients with COPD displayed high levels of IL-1β, both in the area of inflammation, and in blood serum. The latter index was dependent on the severity of disease and activity of inflammatory process. In BALF, the contents of IL-1β in all the patients under study was significantly exceeded the normal levels of this cytokine even at the earliest stages of evolving COPD. concentration in serum was depended at stage of disease and activity of inflammatory procces. There were no differences in IL-1β concentrations in BALF of 2 - 4 stage COPD patients. IL-1ra levels in the patients’ serum were within normal levels, and tended to increase in BAL, thus causing imbalanced IL-1ra/IL-1β ratio both in the inflammatory area, as well as systemically. The maximal detection of respiratory pathogens did significantly correlate with decreased IL-1ra/ IL-1β ratio, thus confirming the data on infectious agents as a pathogenetic component in COPD.
format	article
author	E. A. Surkova N. A. Kuzubova T. P. Ses T. S. Sologub Yu. V. Reztsova N. V. Yakovleva N. V. Egorova
author_facet	E. A. Surkova N. A. Kuzubova T. P. Ses T. S. Sologub Yu. V. Reztsova N. V. Yakovleva N. V. Egorova
author_sort	E. A. Surkova
title	IMBALANCE OF IL -1β И IL -1RA CYTOKINES IN BLOOD SERUM AND BRONCHOALVEOLAR LAVAGE IN COPD PATIENTS
title_short	IMBALANCE OF IL -1β И IL -1RA CYTOKINES IN BLOOD SERUM AND BRONCHOALVEOLAR LAVAGE IN COPD PATIENTS
title_full	IMBALANCE OF IL -1β И IL -1RA CYTOKINES IN BLOOD SERUM AND BRONCHOALVEOLAR LAVAGE IN COPD PATIENTS
title_fullStr	IMBALANCE OF IL -1β И IL -1RA CYTOKINES IN BLOOD SERUM AND BRONCHOALVEOLAR LAVAGE IN COPD PATIENTS
title_full_unstemmed	IMBALANCE OF IL -1β И IL -1RA CYTOKINES IN BLOOD SERUM AND BRONCHOALVEOLAR LAVAGE IN COPD PATIENTS
title_sort	imbalance of il -1β и il -1ra cytokines in blood serum and bronchoalveolar lavage in copd patients
publisher	SPb RAACI
publishDate	2014
url	https://doaj.org/article/1c513bcbc1284ddea6691a12e3a98182
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IMBALANCE OF IL -1β И IL -1RA CYTOKINES IN BLOOD SERUM AND BRONCHOALVEOLAR LAVAGE IN COPD PATIENTS

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