Upper tract urothelial carcinoma has a luminal-papillary T-cell depleted contexture and activated FGFR3 signaling
Upper tract urothelial carcinoma (UTUC) is an aggressive cancer and largely uncharacterised cancer. Here, Faltas and colleagues report its distinctive molecular and immune landscape compared to urothelial carcinoma of the bladder and explore the role of FGFR3 signaling in UTUC biology.
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Nature Portfolio
2019
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oai:doaj.org-article:1c54e7d3caaa498c865d65f8cebe16d42021-12-02T15:35:55ZUpper tract urothelial carcinoma has a luminal-papillary T-cell depleted contexture and activated FGFR3 signaling10.1038/s41467-019-10873-y2041-1723https://doaj.org/article/1c54e7d3caaa498c865d65f8cebe16d42019-07-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-10873-yhttps://doaj.org/toc/2041-1723Upper tract urothelial carcinoma (UTUC) is an aggressive cancer and largely uncharacterised cancer. Here, Faltas and colleagues report its distinctive molecular and immune landscape compared to urothelial carcinoma of the bladder and explore the role of FGFR3 signaling in UTUC biology.Brian D. RobinsonPanagiotis J. VlachostergiosBhavneet BhinderWeisi LiuKailyn LiTyler J. MossRohan BarejaKyung ParkPeyman TavassoliJoanna CyrtaScott T. TagawaDavid M. NanusHimisha BeltranAna M. MolinaFrancesca KhaniJuan Miguel MosqueraEvanguelos XylinasShahrokh F. ShariatDouglas S. ScherrMark A. RubinSeth P. LernerSurena F. MatinOlivier ElementoBishoy M. FaltasNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-11 (2019) |
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| collection |
DOAJ |
| language |
EN |
| topic |
Science Q |
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Science Q Brian D. Robinson Panagiotis J. Vlachostergios Bhavneet Bhinder Weisi Liu Kailyn Li Tyler J. Moss Rohan Bareja Kyung Park Peyman Tavassoli Joanna Cyrta Scott T. Tagawa David M. Nanus Himisha Beltran Ana M. Molina Francesca Khani Juan Miguel Mosquera Evanguelos Xylinas Shahrokh F. Shariat Douglas S. Scherr Mark A. Rubin Seth P. Lerner Surena F. Matin Olivier Elemento Bishoy M. Faltas Upper tract urothelial carcinoma has a luminal-papillary T-cell depleted contexture and activated FGFR3 signaling |
| description |
Upper tract urothelial carcinoma (UTUC) is an aggressive cancer and largely uncharacterised cancer. Here, Faltas and colleagues report its distinctive molecular and immune landscape compared to urothelial carcinoma of the bladder and explore the role of FGFR3 signaling in UTUC biology. |
| format |
article |
| author |
Brian D. Robinson Panagiotis J. Vlachostergios Bhavneet Bhinder Weisi Liu Kailyn Li Tyler J. Moss Rohan Bareja Kyung Park Peyman Tavassoli Joanna Cyrta Scott T. Tagawa David M. Nanus Himisha Beltran Ana M. Molina Francesca Khani Juan Miguel Mosquera Evanguelos Xylinas Shahrokh F. Shariat Douglas S. Scherr Mark A. Rubin Seth P. Lerner Surena F. Matin Olivier Elemento Bishoy M. Faltas |
| author_facet |
Brian D. Robinson Panagiotis J. Vlachostergios Bhavneet Bhinder Weisi Liu Kailyn Li Tyler J. Moss Rohan Bareja Kyung Park Peyman Tavassoli Joanna Cyrta Scott T. Tagawa David M. Nanus Himisha Beltran Ana M. Molina Francesca Khani Juan Miguel Mosquera Evanguelos Xylinas Shahrokh F. Shariat Douglas S. Scherr Mark A. Rubin Seth P. Lerner Surena F. Matin Olivier Elemento Bishoy M. Faltas |
| author_sort |
Brian D. Robinson |
| title |
Upper tract urothelial carcinoma has a luminal-papillary T-cell depleted contexture and activated FGFR3 signaling |
| title_short |
Upper tract urothelial carcinoma has a luminal-papillary T-cell depleted contexture and activated FGFR3 signaling |
| title_full |
Upper tract urothelial carcinoma has a luminal-papillary T-cell depleted contexture and activated FGFR3 signaling |
| title_fullStr |
Upper tract urothelial carcinoma has a luminal-papillary T-cell depleted contexture and activated FGFR3 signaling |
| title_full_unstemmed |
Upper tract urothelial carcinoma has a luminal-papillary T-cell depleted contexture and activated FGFR3 signaling |
| title_sort |
upper tract urothelial carcinoma has a luminal-papillary t-cell depleted contexture and activated fgfr3 signaling |
| publisher |
Nature Portfolio |
| publishDate |
2019 |
| url |
https://doaj.org/article/1c54e7d3caaa498c865d65f8cebe16d4 |
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