Long-term mortality due to infection associated with elevated liver enzymes: a population-based cohort study

Abstract We aimed to investigate whether elevated liver enzymes in the adult population were associated with mortality due to infection. As a population-based cohort study, data from the National Health Insurance Service Health Screening Cohort were used. Adult individuals (aged ≥ 40 years) who unde...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Tak Kyu Oh, Eun Sun Jang, In-Ae Song
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/1c57c6d0091d49819e5ade2ac9a66eb7
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:1c57c6d0091d49819e5ade2ac9a66eb7
record_format	dspace
spelling	oai:doaj.org-article:1c57c6d0091d49819e5ade2ac9a66eb72021-12-02T16:04:18ZLong-term mortality due to infection associated with elevated liver enzymes: a population-based cohort study10.1038/s41598-021-92033-12045-2322https://doaj.org/article/1c57c6d0091d49819e5ade2ac9a66eb72021-06-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-92033-1https://doaj.org/toc/2045-2322Abstract We aimed to investigate whether elevated liver enzymes in the adult population were associated with mortality due to infection. As a population-based cohort study, data from the National Health Insurance Service Health Screening Cohort were used. Adult individuals (aged ≥ 40 years) who underwent standardized medical examination between 2002 and 2003 were included, and infectious mortality was defined as mortality due to infection between 2004 and 2015. Aspartate transaminase (AST), alanine aminotransferase (ALT), γ-glutamyl transpeptidase (γ-GTP), AST/ALT ratio, and dynamic AST/ALT ratio (dAAR) were included in multivariable Cox modeling. A total of 512,746 individuals were included in this study. Infectious mortality occurred in 2444 individuals (0.5%). In the multivariable model, moderate and severe elevation in AST was associated with 1.94-fold [hazard ratio (HR):1.94, 95% confidence interval (CI) 1.71–2.19; P < 0.001] and 3.93-fold (HR: 3.93, 95% CI 3.05–5.07; P < 0.001) higher infectious mortality respectively, compared with the normal AST group. Similar results were observed for moderate and severe elevation in ALT and mild, moderate, and severe elevation in γ-GTP. Additionally, a 1-point increase in the AST/ALT ratio and dAAR was associated with higher infection mortality. Elevated liver enzymes (AST, ALT, AST/ALT ratio, γ-GTP, and dAAR) were associated with increased infectious mortality.Tak Kyu OhEun Sun JangIn-Ae SongNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-11 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Tak Kyu Oh Eun Sun Jang In-Ae Song Long-term mortality due to infection associated with elevated liver enzymes: a population-based cohort study
description	Abstract We aimed to investigate whether elevated liver enzymes in the adult population were associated with mortality due to infection. As a population-based cohort study, data from the National Health Insurance Service Health Screening Cohort were used. Adult individuals (aged ≥ 40 years) who underwent standardized medical examination between 2002 and 2003 were included, and infectious mortality was defined as mortality due to infection between 2004 and 2015. Aspartate transaminase (AST), alanine aminotransferase (ALT), γ-glutamyl transpeptidase (γ-GTP), AST/ALT ratio, and dynamic AST/ALT ratio (dAAR) were included in multivariable Cox modeling. A total of 512,746 individuals were included in this study. Infectious mortality occurred in 2444 individuals (0.5%). In the multivariable model, moderate and severe elevation in AST was associated with 1.94-fold [hazard ratio (HR):1.94, 95% confidence interval (CI) 1.71–2.19; P < 0.001] and 3.93-fold (HR: 3.93, 95% CI 3.05–5.07; P < 0.001) higher infectious mortality respectively, compared with the normal AST group. Similar results were observed for moderate and severe elevation in ALT and mild, moderate, and severe elevation in γ-GTP. Additionally, a 1-point increase in the AST/ALT ratio and dAAR was associated with higher infection mortality. Elevated liver enzymes (AST, ALT, AST/ALT ratio, γ-GTP, and dAAR) were associated with increased infectious mortality.
format	article
author	Tak Kyu Oh Eun Sun Jang In-Ae Song
author_facet	Tak Kyu Oh Eun Sun Jang In-Ae Song
author_sort	Tak Kyu Oh
title	Long-term mortality due to infection associated with elevated liver enzymes: a population-based cohort study
title_short	Long-term mortality due to infection associated with elevated liver enzymes: a population-based cohort study
title_full	Long-term mortality due to infection associated with elevated liver enzymes: a population-based cohort study
title_fullStr	Long-term mortality due to infection associated with elevated liver enzymes: a population-based cohort study
title_full_unstemmed	Long-term mortality due to infection associated with elevated liver enzymes: a population-based cohort study
title_sort	long-term mortality due to infection associated with elevated liver enzymes: a population-based cohort study
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/1c57c6d0091d49819e5ade2ac9a66eb7
work_keys_str_mv	AT takkyuoh longtermmortalityduetoinfectionassociatedwithelevatedliverenzymesapopulationbasedcohortstudy AT eunsunjang longtermmortalityduetoinfectionassociatedwithelevatedliverenzymesapopulationbasedcohortstudy AT inaesong longtermmortalityduetoinfectionassociatedwithelevatedliverenzymesapopulationbasedcohortstudy
_version_	1718385257355411456

Long-term mortality due to infection associated with elevated liver enzymes: a population-based cohort study

Ejemplares similares