Possible Involvement of the Nutrient and Energy Sensors mTORC1 and AMPK in Cell Fate Diversification in a Non-Metazoan Organism
mTORC1 and AMPK are mutually antagonistic sensors of nutrient and energy status that have been implicated in many human diseases including cancer, Alzheimer’s disease, obesity and type 2 diabetes. Starved cells of the social amoeba Dictyostelium discoideum aggregate and eventually form fruiting bodi...
Guardado en:
Autores principales: | Julian D. Gross, Catherine J. Pears |
---|---|
Formato: | article |
Lenguaje: | EN |
Publicado: |
Frontiers Media S.A.
2021
|
Materias: | |
Acceso en línea: | https://doaj.org/article/1c581b558f814ea6bb852af8ae9181dd |
Etiquetas: |
Agregar Etiqueta
Sin Etiquetas, Sea el primero en etiquetar este registro!
|
Ejemplares similares
-
Chronic Activation of AMPK Induces Mitochondrial Biogenesis through Differential Phosphorylation and Abundance of Mitochondrial Proteins in <i>Dictyostelium discoideum</i>
por: Malgorzata Heidorn-Czarna, et al.
Publicado: (2021) -
Targeting TBK1 Attenuates LPS-Induced NLRP3 Inflammasome Activation by Regulating of mTORC1 Pathways in Trophoblasts
por: Sohee Lee, et al.
Publicado: (2021) -
p38 regulates the tumor suppressor PDCD4 via the TSC-mTORC1 pathway
por: Clarissa Braun, et al.
Publicado: (2021) -
A Heat Shock Protein 48 (HSP48) Biomolecular Condensate Is Induced during <named-content content-type="genus-species">Dictyostelium discoideum</named-content> Development
por: Stephanie Santarriaga, et al.
Publicado: (2019) -
mTORC1-induced retinal progenitor cell overproliferation leads to accelerated mitotic aging and degeneration of descendent Müller glia
por: Soyeon Lim, et al.
Publicado: (2021)