Novel Multimodal Management of Post-Partum Synchronous Metastatic Pulmonary EBV-Associated Lymphoepithelioma-Like Carcinoma (LELC)—A Case Report

Primary Epstein-Barr-Virus (EBV)-associated pulmonary lymphoepithelioma-like carcinoma (LELC) is an aggressive rare cancer. Higher incidences have been observed in Asian sub-populations. Multimodal treatment paradigms have emerged as promising novel strategies in the management of advanced NSCLC. In...

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Autores principales:	Montserrat Pazos, Chukwuka Eze, Kathrin Kahnert, Maria Delius, Amanda Tufman, Irene Alba-Alejandre, Marcus Unterrainer, Jens Neumann, Thomas Kirchner, Farkhad Manapov
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	EBV-associated lymphoepithelioma-like lung carcinoma LELC multi-site radiation therapy chemoimmunotherapy lung cancer in pregnancy Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/1c581c1957a149ccbceddc623993682b
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spelling	oai:doaj.org-article:1c581c1957a149ccbceddc623993682b2021-11-25T17:21:23ZNovel Multimodal Management of Post-Partum Synchronous Metastatic Pulmonary EBV-Associated Lymphoepithelioma-Like Carcinoma (LELC)—A Case Report10.3390/diagnostics111120722075-4418https://doaj.org/article/1c581c1957a149ccbceddc623993682b2021-11-01T00:00:00Zhttps://www.mdpi.com/2075-4418/11/11/2072https://doaj.org/toc/2075-4418Primary Epstein-Barr-Virus (EBV)-associated pulmonary lymphoepithelioma-like carcinoma (LELC) is an aggressive rare cancer. Higher incidences have been observed in Asian sub-populations. Multimodal treatment paradigms have emerged as promising novel strategies in the management of advanced NSCLC. In this report, we describe the case of a 34-year-old female patient of Asian origin with a post-partum initial diagnosis of pulmonary LELC. Multimodal treatment with chemoimmunotherapy and hypofractionated irradiation to the primary tumour and main metastatic sites led to a favourable response demonstrating that radiotherapy may potentially augment anti-tumour immunity. To the best of our knowledge, this is the first case report on this novel therapy strategy of multi-site hypofractionated radiotherapy and chemoimmunotherapy for metastatic pulmonary EBV-associated LELC.Montserrat PazosChukwuka EzeKathrin KahnertMaria DeliusAmanda TufmanIrene Alba-AlejandreMarcus UnterrainerJens NeumannThomas KirchnerFarkhad ManapovMDPI AGarticleEBV-associated lymphoepithelioma-like lung carcinomaLELCmulti-site radiation therapychemoimmunotherapylung cancer in pregnancyMedicine (General)R5-920ENDiagnostics, Vol 11, Iss 2072, p 2072 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	EBV-associated lymphoepithelioma-like lung carcinoma LELC multi-site radiation therapy chemoimmunotherapy lung cancer in pregnancy Medicine (General) R5-920
spellingShingle	EBV-associated lymphoepithelioma-like lung carcinoma LELC multi-site radiation therapy chemoimmunotherapy lung cancer in pregnancy Medicine (General) R5-920 Montserrat Pazos Chukwuka Eze Kathrin Kahnert Maria Delius Amanda Tufman Irene Alba-Alejandre Marcus Unterrainer Jens Neumann Thomas Kirchner Farkhad Manapov Novel Multimodal Management of Post-Partum Synchronous Metastatic Pulmonary EBV-Associated Lymphoepithelioma-Like Carcinoma (LELC)—A Case Report
description	Primary Epstein-Barr-Virus (EBV)-associated pulmonary lymphoepithelioma-like carcinoma (LELC) is an aggressive rare cancer. Higher incidences have been observed in Asian sub-populations. Multimodal treatment paradigms have emerged as promising novel strategies in the management of advanced NSCLC. In this report, we describe the case of a 34-year-old female patient of Asian origin with a post-partum initial diagnosis of pulmonary LELC. Multimodal treatment with chemoimmunotherapy and hypofractionated irradiation to the primary tumour and main metastatic sites led to a favourable response demonstrating that radiotherapy may potentially augment anti-tumour immunity. To the best of our knowledge, this is the first case report on this novel therapy strategy of multi-site hypofractionated radiotherapy and chemoimmunotherapy for metastatic pulmonary EBV-associated LELC.
format	article
author	Montserrat Pazos Chukwuka Eze Kathrin Kahnert Maria Delius Amanda Tufman Irene Alba-Alejandre Marcus Unterrainer Jens Neumann Thomas Kirchner Farkhad Manapov
author_facet	Montserrat Pazos Chukwuka Eze Kathrin Kahnert Maria Delius Amanda Tufman Irene Alba-Alejandre Marcus Unterrainer Jens Neumann Thomas Kirchner Farkhad Manapov
author_sort	Montserrat Pazos
title	Novel Multimodal Management of Post-Partum Synchronous Metastatic Pulmonary EBV-Associated Lymphoepithelioma-Like Carcinoma (LELC)—A Case Report
title_short	Novel Multimodal Management of Post-Partum Synchronous Metastatic Pulmonary EBV-Associated Lymphoepithelioma-Like Carcinoma (LELC)—A Case Report
title_full	Novel Multimodal Management of Post-Partum Synchronous Metastatic Pulmonary EBV-Associated Lymphoepithelioma-Like Carcinoma (LELC)—A Case Report
title_fullStr	Novel Multimodal Management of Post-Partum Synchronous Metastatic Pulmonary EBV-Associated Lymphoepithelioma-Like Carcinoma (LELC)—A Case Report
title_full_unstemmed	Novel Multimodal Management of Post-Partum Synchronous Metastatic Pulmonary EBV-Associated Lymphoepithelioma-Like Carcinoma (LELC)—A Case Report
title_sort	novel multimodal management of post-partum synchronous metastatic pulmonary ebv-associated lymphoepithelioma-like carcinoma (lelc)—a case report
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/1c581c1957a149ccbceddc623993682b
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Novel Multimodal Management of Post-Partum Synchronous Metastatic Pulmonary EBV-Associated Lymphoepithelioma-Like Carcinoma (LELC)—A Case Report

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