The control of blood pressure might be important in delaying progression of arterial aging in patients with type 2 diabetes mellitus
GeeHee Kim,1 Ji-Hoon Kim,1 Keon-Woong Moon,1 Ki-Dong Yoo,1 Seung-Hyun Ko,2 Yu-Bae Ahn,2 Chul-Min Kim1 1Division of Cardiology, 2Division of Endocrinology and Metabolism, Department of Internal Medicine, St Vincent’s Hospital, Catholic University of Korea, Suwon, Republic of Korea Objecti...
Guardado en:
| Autores principales: | , , , , , , |
|---|---|
| Formato: | article |
| Lenguaje: | EN |
| Publicado: |
Dove Medical Press
2014
|
| Materias: | |
| Acceso en línea: | https://doaj.org/article/1c5a59285d3a4b6d92d5b6cce59365d8 |
| Etiquetas: |
Agregar Etiqueta
Sin Etiquetas, Sea el primero en etiquetar este registro!
|
| id |
oai:doaj.org-article:1c5a59285d3a4b6d92d5b6cce59365d8 |
|---|---|
| record_format |
dspace |
| spelling |
oai:doaj.org-article:1c5a59285d3a4b6d92d5b6cce59365d82021-12-02T09:03:08ZThe control of blood pressure might be important in delaying progression of arterial aging in patients with type 2 diabetes mellitus1178-1998https://doaj.org/article/1c5a59285d3a4b6d92d5b6cce59365d82014-08-01T00:00:00Zhttps://www.dovepress.com/the-control-of-blood-pressure-might-be-important-in-delaying-progressi-peer-reviewed-article-CIAhttps://doaj.org/toc/1178-1998GeeHee Kim,1 Ji-Hoon Kim,1 Keon-Woong Moon,1 Ki-Dong Yoo,1 Seung-Hyun Ko,2 Yu-Bae Ahn,2 Chul-Min Kim1 1Division of Cardiology, 2Division of Endocrinology and Metabolism, Department of Internal Medicine, St Vincent’s Hospital, Catholic University of Korea, Suwon, Republic of Korea Objective: Arterial stiffness, as assessed by the brachial-ankle pulse wave velocity (baPWV), is associated with arterial aging and has been consistently linked to cardiovascular disease. The factors involved in reducing the progression of arterial stiffness in patients with type 2 diabetes mellitus (DM) have not yet been fully established.Methods: Of 478 patients who underwent two baPWV measurements (at baseline and 1 year later) at the Department of Internal Medicine, St Vincent’s Hospital, from November 2009 to June 2011, 341 subjects were enrolled in this study (male to female ratio =150:191; mean age, 62.1±7.7 years). The 341 subjects were over the age of 50 with type 2 DM, were diagnosed without peripheral artery disease, and 170 if the subjects (50%) had hypertension.Results: baPWV at baseline increased in a linear manner along with age (ß=22.8, t=10.855; P<0.0001, R2=0.258). After 1 year follow-up, the change in baPWV (∆baPWV) was ­variable (median 32.7 cm/s [approximate range, -557 to ~745]). In multiple linear regression, the change in systolic blood pressure (ß=7.142, 95% confidence interval =4.557–9.727; P<0.0001, R2=0.305) was associated with ∆baPWV during follow-up. The change in glycated hemoglobin (HbA1c) and a glycemic control of keeping HbA1c levels below 7.0% were not associated with ∆baPWV.Conclusion: We found that the variation of blood pressure was associated with the progression of vascular aging of the large- to middle-sized arteries in patients with type 2 DM. Therefore, control of blood pressure might be important in reducing arterial aging or PWV in patients with type 2 DM. Keywords: arterial aging, blood pressure, diabetes mellitusKim GHKim JHMoon KWYoo KDKo SHAhn YBKim CMDove Medical Pressarticlearterial agingblood pressurediabetes mellitusGeriatricsRC952-954.6ENClinical Interventions in Aging, Vol Volume 9, Pp 1321-1325 (2014) |
| institution |
DOAJ |
| collection |
DOAJ |
| language |
EN |
| topic |
arterial aging blood pressure diabetes mellitus Geriatrics RC952-954.6 |
| spellingShingle |
arterial aging blood pressure diabetes mellitus Geriatrics RC952-954.6 Kim GH Kim JH Moon KW Yoo KD Ko SH Ahn YB Kim CM The control of blood pressure might be important in delaying progression of arterial aging in patients with type 2 diabetes mellitus |
| description |
GeeHee Kim,1 Ji-Hoon Kim,1 Keon-Woong Moon,1 Ki-Dong Yoo,1 Seung-Hyun Ko,2 Yu-Bae Ahn,2 Chul-Min Kim1 1Division of Cardiology, 2Division of Endocrinology and Metabolism, Department of Internal Medicine, St Vincent’s Hospital, Catholic University of Korea, Suwon, Republic of Korea Objective: Arterial stiffness, as assessed by the brachial-ankle pulse wave velocity (baPWV), is associated with arterial aging and has been consistently linked to cardiovascular disease. The factors involved in reducing the progression of arterial stiffness in patients with type 2 diabetes mellitus (DM) have not yet been fully established.Methods: Of 478 patients who underwent two baPWV measurements (at baseline and 1 year later) at the Department of Internal Medicine, St Vincent’s Hospital, from November 2009 to June 2011, 341 subjects were enrolled in this study (male to female ratio =150:191; mean age, 62.1±7.7 years). The 341 subjects were over the age of 50 with type 2 DM, were diagnosed without peripheral artery disease, and 170 if the subjects (50%) had hypertension.Results: baPWV at baseline increased in a linear manner along with age (ß=22.8, t=10.855; P<0.0001, R2=0.258). After 1 year follow-up, the change in baPWV (∆baPWV) was ­variable (median 32.7 cm/s [approximate range, -557 to ~745]). In multiple linear regression, the change in systolic blood pressure (ß=7.142, 95% confidence interval =4.557–9.727; P<0.0001, R2=0.305) was associated with ∆baPWV during follow-up. The change in glycated hemoglobin (HbA1c) and a glycemic control of keeping HbA1c levels below 7.0% were not associated with ∆baPWV.Conclusion: We found that the variation of blood pressure was associated with the progression of vascular aging of the large- to middle-sized arteries in patients with type 2 DM. Therefore, control of blood pressure might be important in reducing arterial aging or PWV in patients with type 2 DM. Keywords: arterial aging, blood pressure, diabetes mellitus |
| format |
article |
| author |
Kim GH Kim JH Moon KW Yoo KD Ko SH Ahn YB Kim CM |
| author_facet |
Kim GH Kim JH Moon KW Yoo KD Ko SH Ahn YB Kim CM |
| author_sort |
Kim GH |
| title |
The control of blood pressure might be important in delaying progression of arterial aging in patients with type 2 diabetes mellitus |
| title_short |
The control of blood pressure might be important in delaying progression of arterial aging in patients with type 2 diabetes mellitus |
| title_full |
The control of blood pressure might be important in delaying progression of arterial aging in patients with type 2 diabetes mellitus |
| title_fullStr |
The control of blood pressure might be important in delaying progression of arterial aging in patients with type 2 diabetes mellitus |
| title_full_unstemmed |
The control of blood pressure might be important in delaying progression of arterial aging in patients with type 2 diabetes mellitus |
| title_sort |
control of blood pressure might be important in delaying progression of arterial aging in patients with type 2 diabetes mellitus |
| publisher |
Dove Medical Press |
| publishDate |
2014 |
| url |
https://doaj.org/article/1c5a59285d3a4b6d92d5b6cce59365d8 |
| work_keys_str_mv |
AT kimgh thecontrolofbloodpressuremightbeimportantindelayingprogressionofarterialaginginpatientswithtype2diabetesmellitus AT kimjh thecontrolofbloodpressuremightbeimportantindelayingprogressionofarterialaginginpatientswithtype2diabetesmellitus AT moonkw thecontrolofbloodpressuremightbeimportantindelayingprogressionofarterialaginginpatientswithtype2diabetesmellitus AT yookd thecontrolofbloodpressuremightbeimportantindelayingprogressionofarterialaginginpatientswithtype2diabetesmellitus AT kosh thecontrolofbloodpressuremightbeimportantindelayingprogressionofarterialaginginpatientswithtype2diabetesmellitus AT ahnyb thecontrolofbloodpressuremightbeimportantindelayingprogressionofarterialaginginpatientswithtype2diabetesmellitus AT kimcm thecontrolofbloodpressuremightbeimportantindelayingprogressionofarterialaginginpatientswithtype2diabetesmellitus AT kimgh controlofbloodpressuremightbeimportantindelayingprogressionofarterialaginginpatientswithtype2diabetesmellitus AT kimjh controlofbloodpressuremightbeimportantindelayingprogressionofarterialaginginpatientswithtype2diabetesmellitus AT moonkw controlofbloodpressuremightbeimportantindelayingprogressionofarterialaginginpatientswithtype2diabetesmellitus AT yookd controlofbloodpressuremightbeimportantindelayingprogressionofarterialaginginpatientswithtype2diabetesmellitus AT kosh controlofbloodpressuremightbeimportantindelayingprogressionofarterialaginginpatientswithtype2diabetesmellitus AT ahnyb controlofbloodpressuremightbeimportantindelayingprogressionofarterialaginginpatientswithtype2diabetesmellitus AT kimcm controlofbloodpressuremightbeimportantindelayingprogressionofarterialaginginpatientswithtype2diabetesmellitus |
| _version_ |
1718398229260795904 |