Heritable Gut Microbiome Associated with <italic toggle="yes">Salmonella enterica</italic> Serovar Pullorum Infection in Chickens

ABSTRACT Pullorum disease is one of the most common diarrhea-related diseases caused by Salmonella enterica subspecies enterica serovar Gallinarum biovar Pullorum (S. Pullorum); it negatively affects the poultry industry. However, limited studies have explored the association between the gut microbi...

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Autores principales:	Jinmei Ding, Hao Zhou, Lingxiao Luo, Lu Xiao, Kaixuan Yang, Lingyu Yang, Yuming Zheng, Ke Xu, Chuan He, Chengxiao Han, Huaixi Luo, Chao Qin, Fisayo T. Akinyemi, Caiju Gu, Zhenxiang Zhou, Qizhong Huang, He Meng
Formato:	article
Lenguaje:	EN
Publicado:	American Society for Microbiology 2021
Materias:	heritable host genetic variants gut microbiota mGWAS Salmonella Pullorum chicken Microbiology QR1-502
Acceso en línea:	https://doaj.org/article/1c5a8e1a21764fedb834b6390ee3965f
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spelling	oai:doaj.org-article:1c5a8e1a21764fedb834b6390ee3965f2021-12-02T18:20:19ZHeritable Gut Microbiome Associated with <italic toggle="yes">Salmonella enterica</italic> Serovar Pullorum Infection in Chickens10.1128/mSystems.01192-202379-5077https://doaj.org/article/1c5a8e1a21764fedb834b6390ee3965f2021-02-01T00:00:00Zhttps://journals.asm.org/doi/10.1128/mSystems.01192-20https://doaj.org/toc/2379-5077ABSTRACT Pullorum disease is one of the most common diarrhea-related diseases caused by Salmonella enterica subspecies enterica serovar Gallinarum biovar Pullorum (S. Pullorum); it negatively affects the poultry industry. However, limited studies have explored the association between the gut microbiota and S. Pullorum infection in chickens. In the present study, we performed a microbiome comparison and a microbiome genome-wide association study (mGWAS) to investigate the association among the host genetics, the gut microbiota, and pullorum disease in chickens. We found that S. Pullorum infection in chickens could alter the abundance of 39 bacterial genera (P < 0.05). The altered structure and composition of the gut microbiota were also detected in the offspring. mGWAS results revealed host genetic variants to be prominently associated with gut microbial diversity and individual microbes. The pathogens Pelomonas and Brevundimonas, which had a high abundance in positive parent chickens and their offspring, were significantly associated with several genetic mutations in immunity-related genes, such as TGIF1, TTLL12, and CCR7. This finding explained why Pelomonas and Brevundimonas were heritable in S. Pullorum-infected chickens. The heritable gut microbes and identified genetic variants could provide references for the selection of resistant chickens and the elimination of pullorum disease. IMPORTANCE The present study investigated the association among the host genome, the gut microbiome, and S. Pullorum infection in chickens. The results suggested that the gut microbial structure is altered in S. Pullorum-infected chickens. The diversity and abundance of the gut microbiota remarkably differed between the offspring coming from S. Pullorum-positive and S. Pullorum-negative chickens. Heritable gut microbiota were detected in the offspring. Moreover, host genetic variants were associated with microbial diversity and individual gut microbes. The pathogens Pelomonas and Brevundimonas, which exhibited a high heritability in S. Pullorum-positive parents and their offspring, were associated with several genetic mutations in immunity-related genes.Jinmei DingHao ZhouLingxiao LuoLu XiaoKaixuan YangLingyu YangYuming ZhengKe XuChuan HeChengxiao HanHuaixi LuoChao QinFisayo T. AkinyemiCaiju GuZhenxiang ZhouQizhong HuangHe MengAmerican Society for Microbiologyarticleheritablehost genetic variantsgut microbiotamGWASSalmonella PullorumchickenMicrobiologyQR1-502ENmSystems, Vol 6, Iss 1 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	heritable host genetic variants gut microbiota mGWAS Salmonella Pullorum chicken Microbiology QR1-502
spellingShingle	heritable host genetic variants gut microbiota mGWAS Salmonella Pullorum chicken Microbiology QR1-502 Jinmei Ding Hao Zhou Lingxiao Luo Lu Xiao Kaixuan Yang Lingyu Yang Yuming Zheng Ke Xu Chuan He Chengxiao Han Huaixi Luo Chao Qin Fisayo T. Akinyemi Caiju Gu Zhenxiang Zhou Qizhong Huang He Meng Heritable Gut Microbiome Associated with <italic toggle="yes">Salmonella enterica</italic> Serovar Pullorum Infection in Chickens
description	ABSTRACT Pullorum disease is one of the most common diarrhea-related diseases caused by Salmonella enterica subspecies enterica serovar Gallinarum biovar Pullorum (S. Pullorum); it negatively affects the poultry industry. However, limited studies have explored the association between the gut microbiota and S. Pullorum infection in chickens. In the present study, we performed a microbiome comparison and a microbiome genome-wide association study (mGWAS) to investigate the association among the host genetics, the gut microbiota, and pullorum disease in chickens. We found that S. Pullorum infection in chickens could alter the abundance of 39 bacterial genera (P < 0.05). The altered structure and composition of the gut microbiota were also detected in the offspring. mGWAS results revealed host genetic variants to be prominently associated with gut microbial diversity and individual microbes. The pathogens Pelomonas and Brevundimonas, which had a high abundance in positive parent chickens and their offspring, were significantly associated with several genetic mutations in immunity-related genes, such as TGIF1, TTLL12, and CCR7. This finding explained why Pelomonas and Brevundimonas were heritable in S. Pullorum-infected chickens. The heritable gut microbes and identified genetic variants could provide references for the selection of resistant chickens and the elimination of pullorum disease. IMPORTANCE The present study investigated the association among the host genome, the gut microbiome, and S. Pullorum infection in chickens. The results suggested that the gut microbial structure is altered in S. Pullorum-infected chickens. The diversity and abundance of the gut microbiota remarkably differed between the offspring coming from S. Pullorum-positive and S. Pullorum-negative chickens. Heritable gut microbiota were detected in the offspring. Moreover, host genetic variants were associated with microbial diversity and individual gut microbes. The pathogens Pelomonas and Brevundimonas, which exhibited a high heritability in S. Pullorum-positive parents and their offspring, were associated with several genetic mutations in immunity-related genes.
format	article
author	Jinmei Ding Hao Zhou Lingxiao Luo Lu Xiao Kaixuan Yang Lingyu Yang Yuming Zheng Ke Xu Chuan He Chengxiao Han Huaixi Luo Chao Qin Fisayo T. Akinyemi Caiju Gu Zhenxiang Zhou Qizhong Huang He Meng
author_facet	Jinmei Ding Hao Zhou Lingxiao Luo Lu Xiao Kaixuan Yang Lingyu Yang Yuming Zheng Ke Xu Chuan He Chengxiao Han Huaixi Luo Chao Qin Fisayo T. Akinyemi Caiju Gu Zhenxiang Zhou Qizhong Huang He Meng
author_sort	Jinmei Ding
title	Heritable Gut Microbiome Associated with <italic toggle="yes">Salmonella enterica</italic> Serovar Pullorum Infection in Chickens
title_short	Heritable Gut Microbiome Associated with <italic toggle="yes">Salmonella enterica</italic> Serovar Pullorum Infection in Chickens
title_full	Heritable Gut Microbiome Associated with <italic toggle="yes">Salmonella enterica</italic> Serovar Pullorum Infection in Chickens
title_fullStr	Heritable Gut Microbiome Associated with <italic toggle="yes">Salmonella enterica</italic> Serovar Pullorum Infection in Chickens
title_full_unstemmed	Heritable Gut Microbiome Associated with <italic toggle="yes">Salmonella enterica</italic> Serovar Pullorum Infection in Chickens
title_sort	heritable gut microbiome associated with <italic toggle="yes">salmonella enterica</italic> serovar pullorum infection in chickens
publisher	American Society for Microbiology
publishDate	2021
url	https://doaj.org/article/1c5a8e1a21764fedb834b6390ee3965f
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Heritable Gut Microbiome Associated with <italic toggle="yes">Salmonella enterica</italic> Serovar Pullorum Infection in Chickens

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