PROLIFERATIVE AND SECRETORY RESPONSE OF MONONUCLEAR LEUCOCYTES TO COMBINED INFLUENCE OF ETHAMBUTOL AND MYCOBACTERIAL ANTIGENE

Abstract. The article deals with results of studying combined effects of ethambutol and protein antigen of Мycobacterium tuberculosis upon proliferative response and cytokine-producing ability of peripheral blood mononuclear cells in patients with infiltrative lung tuberculosis prior to beginning of...

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Autores principales:	V. A. Serebryakova, O. A. Vasil'eva, O. I. Urazova, V. V. Novitsky, O. V. Voronkova, A. K. Strelis, T. E. Budkina, R. R. Hasanova, I. O. Naslednikova
Formato:	article
Lenguaje:	RU
Publicado:	SPb RAACI 2014
Materias:	pulmonary tuberculosis ethambutol protein antigen of мycobacterium tuberculosis proliferation cytokine production Immunologic diseases. Allergy RC581-607
Acceso en línea:	https://doaj.org/article/1c5f106bdf4345a2bf6aadd51eb8f248
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spelling	oai:doaj.org-article:1c5f106bdf4345a2bf6aadd51eb8f2482021-11-18T08:03:39ZPROLIFERATIVE AND SECRETORY RESPONSE OF MONONUCLEAR LEUCOCYTES TO COMBINED INFLUENCE OF ETHAMBUTOL AND MYCOBACTERIAL ANTIGENE1563-06252313-741X10.15789/1563-0625-2009-2-3-https://doaj.org/article/1c5f106bdf4345a2bf6aadd51eb8f2482014-07-01T00:00:00Zhttps://www.mimmun.ru/mimmun/article/view/279https://doaj.org/toc/1563-0625https://doaj.org/toc/2313-741XAbstract. The article deals with results of studying combined effects of ethambutol and protein antigen of Мycobacterium tuberculosis upon proliferative response and cytokine-producing ability of peripheral blood mononuclear cells in patients with infiltrative lung tuberculosis prior to beginning of specific antibacterial therapy. The mononuclear blood cells were cultivated with complex protein antigen of Мycobacterium tuberculosis and ethambutol. In the patients with lung tuberculosis, a decrease in proliferative reserve of lymphocytes was detected, in absence of increased IL-2 and IL-10 secretion. The combined effect of ethambutol and protein antigen of Мycobacterium tuberculosis upon peripheral blood mononuclear cells in the patients with pulmonary tuberculosis and healthy donors was similar, and it was expressed as antiproliferative effect and selective suppression of IFNγ production.V. A. SerebryakovaO. A. Vasil'evaO. I. UrazovaV. V. NovitskyO. V. VoronkovaA. K. StrelisT. E. BudkinaR. R. HasanovaI. O. NaslednikovaSPb RAACIarticlepulmonary tuberculosisethambutolprotein antigen of мycobacterium tuberculosisproliferationcytokine productionImmunologic diseases. AllergyRC581-607RUMedicinskaâ Immunologiâ, Vol 11, Iss 2-3, Pp 153-160 (2014)
institution	DOAJ
collection	DOAJ
language	RU
topic	pulmonary tuberculosis ethambutol protein antigen of мycobacterium tuberculosis proliferation cytokine production Immunologic diseases. Allergy RC581-607
spellingShingle	pulmonary tuberculosis ethambutol protein antigen of мycobacterium tuberculosis proliferation cytokine production Immunologic diseases. Allergy RC581-607 V. A. Serebryakova O. A. Vasil'eva O. I. Urazova V. V. Novitsky O. V. Voronkova A. K. Strelis T. E. Budkina R. R. Hasanova I. O. Naslednikova PROLIFERATIVE AND SECRETORY RESPONSE OF MONONUCLEAR LEUCOCYTES TO COMBINED INFLUENCE OF ETHAMBUTOL AND MYCOBACTERIAL ANTIGENE
description	Abstract. The article deals with results of studying combined effects of ethambutol and protein antigen of Мycobacterium tuberculosis upon proliferative response and cytokine-producing ability of peripheral blood mononuclear cells in patients with infiltrative lung tuberculosis prior to beginning of specific antibacterial therapy. The mononuclear blood cells were cultivated with complex protein antigen of Мycobacterium tuberculosis and ethambutol. In the patients with lung tuberculosis, a decrease in proliferative reserve of lymphocytes was detected, in absence of increased IL-2 and IL-10 secretion. The combined effect of ethambutol and protein antigen of Мycobacterium tuberculosis upon peripheral blood mononuclear cells in the patients with pulmonary tuberculosis and healthy donors was similar, and it was expressed as antiproliferative effect and selective suppression of IFNγ production.
format	article
author	V. A. Serebryakova O. A. Vasil'eva O. I. Urazova V. V. Novitsky O. V. Voronkova A. K. Strelis T. E. Budkina R. R. Hasanova I. O. Naslednikova
author_facet	V. A. Serebryakova O. A. Vasil'eva O. I. Urazova V. V. Novitsky O. V. Voronkova A. K. Strelis T. E. Budkina R. R. Hasanova I. O. Naslednikova
author_sort	V. A. Serebryakova
title	PROLIFERATIVE AND SECRETORY RESPONSE OF MONONUCLEAR LEUCOCYTES TO COMBINED INFLUENCE OF ETHAMBUTOL AND MYCOBACTERIAL ANTIGENE
title_short	PROLIFERATIVE AND SECRETORY RESPONSE OF MONONUCLEAR LEUCOCYTES TO COMBINED INFLUENCE OF ETHAMBUTOL AND MYCOBACTERIAL ANTIGENE
title_full	PROLIFERATIVE AND SECRETORY RESPONSE OF MONONUCLEAR LEUCOCYTES TO COMBINED INFLUENCE OF ETHAMBUTOL AND MYCOBACTERIAL ANTIGENE
title_fullStr	PROLIFERATIVE AND SECRETORY RESPONSE OF MONONUCLEAR LEUCOCYTES TO COMBINED INFLUENCE OF ETHAMBUTOL AND MYCOBACTERIAL ANTIGENE
title_full_unstemmed	PROLIFERATIVE AND SECRETORY RESPONSE OF MONONUCLEAR LEUCOCYTES TO COMBINED INFLUENCE OF ETHAMBUTOL AND MYCOBACTERIAL ANTIGENE
title_sort	proliferative and secretory response of mononuclear leucocytes to combined influence of ethambutol and mycobacterial antigene
publisher	SPb RAACI
publishDate	2014
url	https://doaj.org/article/1c5f106bdf4345a2bf6aadd51eb8f248
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PROLIFERATIVE AND SECRETORY RESPONSE OF MONONUCLEAR LEUCOCYTES TO COMBINED INFLUENCE OF ETHAMBUTOL AND MYCOBACTERIAL ANTIGENE

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