Bilevel Positive Airway Pressure Ventilation for Improving Respiratory Reproducibility in Radiation Oncology: A Pilot Study

Background: Strategies for managing respiratory motion, specifically motion-encompassing methods, in radiation therapy typically assume reproducible breathing. In reality, respiratory motion variations occur and ultimately cause tumor motion variations, which can result in differences between the pl...

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Autores principales:	Cameron J. Sprowls, MS, Connel Chu, MS, Phillip D.H. Wall, PhD, Jonas D. Fontenot, PhD
Formato:	article
Lenguaje:	EN
Publicado:	Elsevier 2022
Materias:	Medical physics. Medical radiology. Nuclear medicine R895-920 Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282
Acceso en línea:	https://doaj.org/article/1c5f829b7ac244b3beb2bf77758972e5
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spelling	oai:doaj.org-article:1c5f829b7ac244b3beb2bf77758972e52021-11-12T04:43:14ZBilevel Positive Airway Pressure Ventilation for Improving Respiratory Reproducibility in Radiation Oncology: A Pilot Study2452-109410.1016/j.adro.2021.100780https://doaj.org/article/1c5f829b7ac244b3beb2bf77758972e52022-03-01T00:00:00Zhttp://www.sciencedirect.com/science/article/pii/S245210942100138Xhttps://doaj.org/toc/2452-1094Background: Strategies for managing respiratory motion, specifically motion-encompassing methods, in radiation therapy typically assume reproducible breathing. In reality, respiratory motion variations occur and ultimately cause tumor motion variations, which can result in differences between the planned and delivered dose distributions. Therefore, breathing guidance techniques have been investigated to improve respiratory reproducibility. To our knowledge, bilevel positive airway pressure (BIPAP) ventilation assistance has not been previously investigated as a technique for improving respiratory reproducibility and is the focus of this work. Methods and Materials: Ten patients undergoing radiation therapy treatment for cancers affected by respiratory motion (eg, lung and esophagus) participated in sessions in which their breathing was recorded during their course of treatment; these sessions occurred either before or after radiation treatments. Both unassisted free-breathing (FB) and BIPAP ventilation-assisted respiratory volume data were collected from each patient using spirometry. Patients used 2 different BIPAP ventilators (fixed BIPAP and flexible BIPAP), each configured to deliver the same volume of air per breath (ie, tidal volume). The flexible BIPAP ventilator permitted patient triggering (ie, it permitted patients to initiate each breath), and the fixed BIPAP did not. Intrasession and intersession metrics quantifying tidal volume variations were calculated and compared between the specific breathing platforms (FB or BIPAP). In addition, patient tolerance of both BIPAP ventilators was qualitatively assessed through verbal feedback. Results: Both BIPAP ventilators were tolerated by patients, although the fixed BIPAP was not as well tolerated as the flexible BIPAP. Both BIPAP ventilators showed significant reductions (P < .05) in intrasession tidal volume variation compared with FB. However, only the fixed BIPAP significantly reduced the intersession tidal volume variation compared with FB. Conclusions: Based on the established correlation between tidal volume and tumor motion, any reduction of the tidal volume variation could result in reduced tumor motion variation. Fixed BIPAP ventilation was found to be tolerated by patients and was shown to significantly reduce intrasession and intersession tidal volume variations compared with FB. Therefore, future investigation into the potential of fixed BIPAP ventilation is warranted to define the possible clinical benefits.Cameron J. Sprowls, MSConnel Chu, MSPhillip D.H. Wall, PhDJonas D. Fontenot, PhDElsevierarticleMedical physics. Medical radiology. Nuclear medicineR895-920Neoplasms. Tumors. Oncology. Including cancer and carcinogensRC254-282ENAdvances in Radiation Oncology, Vol 7, Iss 2, Pp 100780- (2022)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medical physics. Medical radiology. Nuclear medicine R895-920 Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282
spellingShingle	Medical physics. Medical radiology. Nuclear medicine R895-920 Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282 Cameron J. Sprowls, MS Connel Chu, MS Phillip D.H. Wall, PhD Jonas D. Fontenot, PhD Bilevel Positive Airway Pressure Ventilation for Improving Respiratory Reproducibility in Radiation Oncology: A Pilot Study
description	Background: Strategies for managing respiratory motion, specifically motion-encompassing methods, in radiation therapy typically assume reproducible breathing. In reality, respiratory motion variations occur and ultimately cause tumor motion variations, which can result in differences between the planned and delivered dose distributions. Therefore, breathing guidance techniques have been investigated to improve respiratory reproducibility. To our knowledge, bilevel positive airway pressure (BIPAP) ventilation assistance has not been previously investigated as a technique for improving respiratory reproducibility and is the focus of this work. Methods and Materials: Ten patients undergoing radiation therapy treatment for cancers affected by respiratory motion (eg, lung and esophagus) participated in sessions in which their breathing was recorded during their course of treatment; these sessions occurred either before or after radiation treatments. Both unassisted free-breathing (FB) and BIPAP ventilation-assisted respiratory volume data were collected from each patient using spirometry. Patients used 2 different BIPAP ventilators (fixed BIPAP and flexible BIPAP), each configured to deliver the same volume of air per breath (ie, tidal volume). The flexible BIPAP ventilator permitted patient triggering (ie, it permitted patients to initiate each breath), and the fixed BIPAP did not. Intrasession and intersession metrics quantifying tidal volume variations were calculated and compared between the specific breathing platforms (FB or BIPAP). In addition, patient tolerance of both BIPAP ventilators was qualitatively assessed through verbal feedback. Results: Both BIPAP ventilators were tolerated by patients, although the fixed BIPAP was not as well tolerated as the flexible BIPAP. Both BIPAP ventilators showed significant reductions (P < .05) in intrasession tidal volume variation compared with FB. However, only the fixed BIPAP significantly reduced the intersession tidal volume variation compared with FB. Conclusions: Based on the established correlation between tidal volume and tumor motion, any reduction of the tidal volume variation could result in reduced tumor motion variation. Fixed BIPAP ventilation was found to be tolerated by patients and was shown to significantly reduce intrasession and intersession tidal volume variations compared with FB. Therefore, future investigation into the potential of fixed BIPAP ventilation is warranted to define the possible clinical benefits.
format	article
author	Cameron J. Sprowls, MS Connel Chu, MS Phillip D.H. Wall, PhD Jonas D. Fontenot, PhD
author_facet	Cameron J. Sprowls, MS Connel Chu, MS Phillip D.H. Wall, PhD Jonas D. Fontenot, PhD
author_sort	Cameron J. Sprowls, MS
title	Bilevel Positive Airway Pressure Ventilation for Improving Respiratory Reproducibility in Radiation Oncology: A Pilot Study
title_short	Bilevel Positive Airway Pressure Ventilation for Improving Respiratory Reproducibility in Radiation Oncology: A Pilot Study
title_full	Bilevel Positive Airway Pressure Ventilation for Improving Respiratory Reproducibility in Radiation Oncology: A Pilot Study
title_fullStr	Bilevel Positive Airway Pressure Ventilation for Improving Respiratory Reproducibility in Radiation Oncology: A Pilot Study
title_full_unstemmed	Bilevel Positive Airway Pressure Ventilation for Improving Respiratory Reproducibility in Radiation Oncology: A Pilot Study
title_sort	bilevel positive airway pressure ventilation for improving respiratory reproducibility in radiation oncology: a pilot study
publisher	Elsevier
publishDate	2022
url	https://doaj.org/article/1c5f829b7ac244b3beb2bf77758972e5
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Bilevel Positive Airway Pressure Ventilation for Improving Respiratory Reproducibility in Radiation Oncology: A Pilot Study

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