Ketone body 3-hydroxybutyrate as a biomarker of aggression

Abstract Human aggression is a complex behaviour, the biological underpinnings of which remain poorly known. To gain insights into aggression biology, we studied relationships with aggression of 11 low-molecular-weight metabolites (amino acids, ketone bodies), processed using 1H nuclear magnetic res...

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Autores principales:	A. M. Whipp, E. Vuoksimaa, T. Korhonen, R. Pool, A. But, L. Ligthart, F. A. Hagenbeek, M. Bartels, L. H. Bogl, L. Pulkkinen, R. J. Rose, D. I. Boomsma, J. Kaprio
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/1c60f011ca1b41f98206c6ab169b3fa6
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spelling	oai:doaj.org-article:1c60f011ca1b41f98206c6ab169b3fa62021-12-02T15:52:19ZKetone body 3-hydroxybutyrate as a biomarker of aggression10.1038/s41598-021-84635-62045-2322https://doaj.org/article/1c60f011ca1b41f98206c6ab169b3fa62021-03-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-84635-6https://doaj.org/toc/2045-2322Abstract Human aggression is a complex behaviour, the biological underpinnings of which remain poorly known. To gain insights into aggression biology, we studied relationships with aggression of 11 low-molecular-weight metabolites (amino acids, ketone bodies), processed using 1H nuclear magnetic resonance spectroscopy. We used a discovery sample of young adults and an independent adult replication sample. We studied 725 young adults from a population-based Finnish twin cohort born 1983–1987, with aggression levels rated in adolescence (ages 12, 14, 17) by multiple raters and blood plasma samples at age 22. Linear regression models specified metabolites as the response variable and aggression ratings as predictor variables, and included several potential confounders. All metabolites showed low correlations with aggression, with only one—3-hydroxybutyrate, a ketone body produced during fasting—showing significant (negative) associations with aggression. Effect sizes for different raters were generally similar in magnitude, while teacher-rated (age 12) and self-rated (age 14) aggression were both significant predictors of 3-hydroxybutyrate in multi-rater models. In an independent replication sample of 960 adults from the Netherlands Twin Register, higher aggression (self-rated) was also related to lower levels of 3-hydroxybutyrate. These exploratory epidemiologic results warrant further studies on the role of ketone metabolism in aggression.A. M. WhippE. VuoksimaaT. KorhonenR. PoolA. ButL. LigthartF. A. HagenbeekM. BartelsL. H. BoglL. PulkkinenR. J. RoseD. I. BoomsmaJ. KaprioNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-10 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q A. M. Whipp E. Vuoksimaa T. Korhonen R. Pool A. But L. Ligthart F. A. Hagenbeek M. Bartels L. H. Bogl L. Pulkkinen R. J. Rose D. I. Boomsma J. Kaprio Ketone body 3-hydroxybutyrate as a biomarker of aggression
description	Abstract Human aggression is a complex behaviour, the biological underpinnings of which remain poorly known. To gain insights into aggression biology, we studied relationships with aggression of 11 low-molecular-weight metabolites (amino acids, ketone bodies), processed using 1H nuclear magnetic resonance spectroscopy. We used a discovery sample of young adults and an independent adult replication sample. We studied 725 young adults from a population-based Finnish twin cohort born 1983–1987, with aggression levels rated in adolescence (ages 12, 14, 17) by multiple raters and blood plasma samples at age 22. Linear regression models specified metabolites as the response variable and aggression ratings as predictor variables, and included several potential confounders. All metabolites showed low correlations with aggression, with only one—3-hydroxybutyrate, a ketone body produced during fasting—showing significant (negative) associations with aggression. Effect sizes for different raters were generally similar in magnitude, while teacher-rated (age 12) and self-rated (age 14) aggression were both significant predictors of 3-hydroxybutyrate in multi-rater models. In an independent replication sample of 960 adults from the Netherlands Twin Register, higher aggression (self-rated) was also related to lower levels of 3-hydroxybutyrate. These exploratory epidemiologic results warrant further studies on the role of ketone metabolism in aggression.
format	article
author	A. M. Whipp E. Vuoksimaa T. Korhonen R. Pool A. But L. Ligthart F. A. Hagenbeek M. Bartels L. H. Bogl L. Pulkkinen R. J. Rose D. I. Boomsma J. Kaprio
author_facet	A. M. Whipp E. Vuoksimaa T. Korhonen R. Pool A. But L. Ligthart F. A. Hagenbeek M. Bartels L. H. Bogl L. Pulkkinen R. J. Rose D. I. Boomsma J. Kaprio
author_sort	A. M. Whipp
title	Ketone body 3-hydroxybutyrate as a biomarker of aggression
title_short	Ketone body 3-hydroxybutyrate as a biomarker of aggression
title_full	Ketone body 3-hydroxybutyrate as a biomarker of aggression
title_fullStr	Ketone body 3-hydroxybutyrate as a biomarker of aggression
title_full_unstemmed	Ketone body 3-hydroxybutyrate as a biomarker of aggression
title_sort	ketone body 3-hydroxybutyrate as a biomarker of aggression
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/1c60f011ca1b41f98206c6ab169b3fa6
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Ketone body 3-hydroxybutyrate as a biomarker of aggression

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