Altered spontaneous brain activity pattern in patients with high myopia using amplitude of low-frequency fluctuation: a resting-state fMRI study

Xin Huang,1,2,* Fu-Qing Zhou,3,* Yu-Xiang Hu,1 Xiao-Xuan Xu,1 Xiong Zhou,4 Yu-Lin Zhong,1 Jun Wang,4 Xiao-Rong Wu1 1Department of Ophthalmology, The First Affiliated Hospital of Nanchang University, Nanchang, 2Department of Ophthalmology, The First People’s Hospital of Jiujiang City, Jiuj...

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Autores principales:	Huang X, Zhou FQ, Hu YX, Xu XX, Zhou X, Zhong YL, Wang J, Wu XR
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2016
Materias:	ALFF high myopic resting state spontaneous activity Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429
Acceso en línea:	https://doaj.org/article/1c6466ca68384e519b2dd8c7111568d7
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spelling	oai:doaj.org-article:1c6466ca68384e519b2dd8c7111568d72021-12-02T06:02:51ZAltered spontaneous brain activity pattern in patients with high myopia using amplitude of low-frequency fluctuation: a resting-state fMRI study1178-2021https://doaj.org/article/1c6466ca68384e519b2dd8c7111568d72016-11-01T00:00:00Zhttps://www.dovepress.com/altered-spontaneous-brain-activity-pattern-in-patients-with-high-myopi-peer-reviewed-article-NDThttps://doaj.org/toc/1178-2021Xin Huang,1,2,* Fu-Qing Zhou,3,* Yu-Xiang Hu,1 Xiao-Xuan Xu,1 Xiong Zhou,4 Yu-Lin Zhong,1 Jun Wang,4 Xiao-Rong Wu1 1Department of Ophthalmology, The First Affiliated Hospital of Nanchang University, Nanchang, 2Department of Ophthalmology, The First People’s Hospital of Jiujiang City, Jiujiang, 3Department of Radiology, The First Affiliated Hospital of Nanchang University, Jiangxi Province Medical Imaging Research Institute, 4Second Department of Respiratory Disease, Jiangxi Provincial People’s Hospital, Nanchang, Jiangxi, People’s Republic of China *These authors contributed equally to this work Objective: Many previous reports have demonstrated significant neural anatomy changes in the brain of high myopic (HM) patients, whereas the spontaneous brain activity changes in the HM patients at rest are not well studied. Our objective was to use amplitude of low-frequency fluctuation (ALFF) method to investigate the changes in spontaneous brain activity in HM patients and their relationships with clinical features. Methods: A total of 38 patients with HM (17 males and 21 females) and 38 healthy controls (HCs) (17 males and 21 females) closely matched in age, sex, and education underwent resting-state functional magnetic resonance imaging scans. The ALFF method was used to assess local features of spontaneous brain activity. The relationship between the mean ALFF signal values in many brain regions and the clinical features in HM patients was calculated by correlation analysis. Results: Compared with HCs, the HM patients had significantly lower ALFF in the right inferior and middle temporal gyrus, left middle temporal gyrus, left inferior frontal gyrus/putamen, right inferior frontal gyrus/putamen/insula, right middle frontal gyrus, and right inferior parietal lobule and higher ALFF values in the bilateral midcingulate cortex, left postcentral gyrus, and left precuneus/inferior parietal lobule. However, no relationship was found between the mean ALFF signal values of the different areas and the clinical manifestations in HM. Conclusion: The HM patients were affected with brain dysfunction in many regions, which may indicate the presence of neurobiological changes involving deficits in language understanding and attentional control in HM patients. Keywords: ALFF, high myopic, resting state, functional magnetic resonance imagingHuang XZhou FQHu YXXu XXZhou XZhong YLWang JWu XRDove Medical PressarticleALFFhigh myopicresting statespontaneous activityNeurosciences. Biological psychiatry. NeuropsychiatryRC321-571Neurology. Diseases of the nervous systemRC346-429ENNeuropsychiatric Disease and Treatment, Vol Volume 12, Pp 2949-2956 (2016)
institution	DOAJ
collection	DOAJ
language	EN
topic	ALFF high myopic resting state spontaneous activity Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429
spellingShingle	ALFF high myopic resting state spontaneous activity Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429 Huang X Zhou FQ Hu YX Xu XX Zhou X Zhong YL Wang J Wu XR Altered spontaneous brain activity pattern in patients with high myopia using amplitude of low-frequency fluctuation: a resting-state fMRI study
description	Xin Huang,1,2,* Fu-Qing Zhou,3,* Yu-Xiang Hu,1 Xiao-Xuan Xu,1 Xiong Zhou,4 Yu-Lin Zhong,1 Jun Wang,4 Xiao-Rong Wu1 1Department of Ophthalmology, The First Affiliated Hospital of Nanchang University, Nanchang, 2Department of Ophthalmology, The First People’s Hospital of Jiujiang City, Jiujiang, 3Department of Radiology, The First Affiliated Hospital of Nanchang University, Jiangxi Province Medical Imaging Research Institute, 4Second Department of Respiratory Disease, Jiangxi Provincial People’s Hospital, Nanchang, Jiangxi, People’s Republic of China *These authors contributed equally to this work Objective: Many previous reports have demonstrated significant neural anatomy changes in the brain of high myopic (HM) patients, whereas the spontaneous brain activity changes in the HM patients at rest are not well studied. Our objective was to use amplitude of low-frequency fluctuation (ALFF) method to investigate the changes in spontaneous brain activity in HM patients and their relationships with clinical features. Methods: A total of 38 patients with HM (17 males and 21 females) and 38 healthy controls (HCs) (17 males and 21 females) closely matched in age, sex, and education underwent resting-state functional magnetic resonance imaging scans. The ALFF method was used to assess local features of spontaneous brain activity. The relationship between the mean ALFF signal values in many brain regions and the clinical features in HM patients was calculated by correlation analysis. Results: Compared with HCs, the HM patients had significantly lower ALFF in the right inferior and middle temporal gyrus, left middle temporal gyrus, left inferior frontal gyrus/putamen, right inferior frontal gyrus/putamen/insula, right middle frontal gyrus, and right inferior parietal lobule and higher ALFF values in the bilateral midcingulate cortex, left postcentral gyrus, and left precuneus/inferior parietal lobule. However, no relationship was found between the mean ALFF signal values of the different areas and the clinical manifestations in HM. Conclusion: The HM patients were affected with brain dysfunction in many regions, which may indicate the presence of neurobiological changes involving deficits in language understanding and attentional control in HM patients. Keywords: ALFF, high myopic, resting state, functional magnetic resonance imaging
format	article
author	Huang X Zhou FQ Hu YX Xu XX Zhou X Zhong YL Wang J Wu XR
author_facet	Huang X Zhou FQ Hu YX Xu XX Zhou X Zhong YL Wang J Wu XR
author_sort	Huang X
title	Altered spontaneous brain activity pattern in patients with high myopia using amplitude of low-frequency fluctuation: a resting-state fMRI study
title_short	Altered spontaneous brain activity pattern in patients with high myopia using amplitude of low-frequency fluctuation: a resting-state fMRI study
title_full	Altered spontaneous brain activity pattern in patients with high myopia using amplitude of low-frequency fluctuation: a resting-state fMRI study
title_fullStr	Altered spontaneous brain activity pattern in patients with high myopia using amplitude of low-frequency fluctuation: a resting-state fMRI study
title_full_unstemmed	Altered spontaneous brain activity pattern in patients with high myopia using amplitude of low-frequency fluctuation: a resting-state fMRI study
title_sort	altered spontaneous brain activity pattern in patients with high myopia using amplitude of low-frequency fluctuation: a resting-state fmri study
publisher	Dove Medical Press
publishDate	2016
url	https://doaj.org/article/1c6466ca68384e519b2dd8c7111568d7
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Altered spontaneous brain activity pattern in patients with high myopia using amplitude of low-frequency fluctuation: a resting-state fMRI study

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