Cerebellar contribution to sensorimotor adaptation deficits in humans with spinal cord injury

Abstract Humans with spinal cord injury (SCI) show deficits in associating motor commands and sensory feedback. Do these deficits affect their ability to adapt movements to new demands? To address this question, we used a robotic exoskeleton to examine learning of a sensorimotor adaptation task duri...

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Autores principales:	Yuming Lei, Monica A. Perez
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/1c65186ff7354fb8b21a97df667ae4b8
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spelling	oai:doaj.org-article:1c65186ff7354fb8b21a97df667ae4b82021-12-02T13:57:38ZCerebellar contribution to sensorimotor adaptation deficits in humans with spinal cord injury10.1038/s41598-020-77543-82045-2322https://doaj.org/article/1c65186ff7354fb8b21a97df667ae4b82021-01-01T00:00:00Zhttps://doi.org/10.1038/s41598-020-77543-8https://doaj.org/toc/2045-2322Abstract Humans with spinal cord injury (SCI) show deficits in associating motor commands and sensory feedback. Do these deficits affect their ability to adapt movements to new demands? To address this question, we used a robotic exoskeleton to examine learning of a sensorimotor adaptation task during reaching movements by distorting the relationship between hand movement and visual feedback in 22 individuals with chronic incomplete cervical SCI and 22 age-matched control subjects. We found that SCI individuals showed a reduced ability to learn from movement errors compared with control subjects. Sensorimotor areas in anterior and posterior cerebellar lobules contribute to learning of movement errors in intact humans. Structural brain imaging showed that sensorimotor areas in the cerebellum, including lobules I–VI, were reduced in size in SCI compared with control subjects and cerebellar atrophy increased with increasing time post injury. Notably, the degree of spared tissue in the cerebellum was positively correlated with learning rates, indicating participants with lesser atrophy showed higher learning rates. These results suggest that the reduced ability to learn from movement errors during reaching movements in humans with SCI involves abnormalities in the spinocerebellar structures. We argue that this information might help in the rehabilitation of people with SCI.Yuming LeiMonica A. PerezNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-13 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Yuming Lei Monica A. Perez Cerebellar contribution to sensorimotor adaptation deficits in humans with spinal cord injury
description	Abstract Humans with spinal cord injury (SCI) show deficits in associating motor commands and sensory feedback. Do these deficits affect their ability to adapt movements to new demands? To address this question, we used a robotic exoskeleton to examine learning of a sensorimotor adaptation task during reaching movements by distorting the relationship between hand movement and visual feedback in 22 individuals with chronic incomplete cervical SCI and 22 age-matched control subjects. We found that SCI individuals showed a reduced ability to learn from movement errors compared with control subjects. Sensorimotor areas in anterior and posterior cerebellar lobules contribute to learning of movement errors in intact humans. Structural brain imaging showed that sensorimotor areas in the cerebellum, including lobules I–VI, were reduced in size in SCI compared with control subjects and cerebellar atrophy increased with increasing time post injury. Notably, the degree of spared tissue in the cerebellum was positively correlated with learning rates, indicating participants with lesser atrophy showed higher learning rates. These results suggest that the reduced ability to learn from movement errors during reaching movements in humans with SCI involves abnormalities in the spinocerebellar structures. We argue that this information might help in the rehabilitation of people with SCI.
format	article
author	Yuming Lei Monica A. Perez
author_facet	Yuming Lei Monica A. Perez
author_sort	Yuming Lei
title	Cerebellar contribution to sensorimotor adaptation deficits in humans with spinal cord injury
title_short	Cerebellar contribution to sensorimotor adaptation deficits in humans with spinal cord injury
title_full	Cerebellar contribution to sensorimotor adaptation deficits in humans with spinal cord injury
title_fullStr	Cerebellar contribution to sensorimotor adaptation deficits in humans with spinal cord injury
title_full_unstemmed	Cerebellar contribution to sensorimotor adaptation deficits in humans with spinal cord injury
title_sort	cerebellar contribution to sensorimotor adaptation deficits in humans with spinal cord injury
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/1c65186ff7354fb8b21a97df667ae4b8
work_keys_str_mv	AT yuminglei cerebellarcontributiontosensorimotoradaptationdeficitsinhumanswithspinalcordinjury AT monicaaperez cerebellarcontributiontosensorimotoradaptationdeficitsinhumanswithspinalcordinjury
_version_	1718392245745352704

Cerebellar contribution to sensorimotor adaptation deficits in humans with spinal cord injury

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