COVID-19 outcomes in hospitalized puerperal, pregnant, and neither pregnant nor puerperal women.

<h4>Objective</h4>To compare hospitalized reproductive age women with COVID-19 who were pregnant, puerperal, or neither one nor the other in terms of demographic and clinical characteristics and disease progression using Brazilian epidemiological data.<h4>Methods</h4>A retros...

Descripción completa

Guardado en:
Detalles Bibliográficos
Autores principales: Fabiano Elisei Serra, Rossana Pulcineli Vieira Francisco, Patricia de Rossi, Maria de Lourdes Brizot, Agatha Sacramento Rodrigues
Formato: article
Lenguaje:EN
Publicado: Public Library of Science (PLoS) 2021
Materias:
R
Q
Acceso en línea:https://doaj.org/article/1c6780a501234b8c98d97a4f890f6415
Etiquetas: Agregar Etiqueta
Sin Etiquetas, Sea el primero en etiquetar este registro!
id oai:doaj.org-article:1c6780a501234b8c98d97a4f890f6415
record_format dspace
spelling oai:doaj.org-article:1c6780a501234b8c98d97a4f890f64152021-12-02T20:16:21ZCOVID-19 outcomes in hospitalized puerperal, pregnant, and neither pregnant nor puerperal women.1932-620310.1371/journal.pone.0259911https://doaj.org/article/1c6780a501234b8c98d97a4f890f64152021-01-01T00:00:00Zhttps://doi.org/10.1371/journal.pone.0259911https://doaj.org/toc/1932-6203<h4>Objective</h4>To compare hospitalized reproductive age women with COVID-19 who were pregnant, puerperal, or neither one nor the other in terms of demographic and clinical characteristics and disease progression using Brazilian epidemiological data.<h4>Methods</h4>A retrospective analysis of the records of the Information System of the Epidemiological Surveillance of Influenza of the Health Ministry of Brazil was performed. It included the data of female patients aged 10 to 49 years hospitalized because of severe COVID-19 disease (RT-PCR+ for SARS-CoV-2), from February 17, 2020 to January 02, 2021. They were separated into 3 groups: pregnant, puerperal, and neither pregnant nor puerperal. General comparisons and then adjustments for confounding variables (propensity score matching [PSM]) were made, using demographic and clinical characteristics, disease progression (admission to the intensive care unit [ICU] and invasive or noninvasive ventilatory support), and outcome (cure or death). Deaths were analyzed in each group according to comorbidities, invasive or noninvasive ventilatory support, and admission to the ICU.<h4>Results</h4>As many as 40,640 reproductive age women hospitalized for COVID-19 were identified: 3,372 were pregnant, 794 were puerperal, and 36,474 were neither pregnant nor puerperal. Groups were significantly different in terms of demographic data and comorbidities (p<0.0001). Pregnant and puerperal women were less likely to be symptomatic than the women who were neither one nor the other (72.1%, 69.7% and 88.8%, respectively). Pregnant women, however, had a higher frequency of anosmia, and ageusia than the others. After PSM, puerperal women had a worse prognosis than pregnant women with respect to admission to the ICU, invasive ventilatory support, and death, with OR (95% CI) 1.97 (1.55 - 2.50), 2.71 (1.78 - 4.13), and 2.51 (1.79 - 3.52), respectively.<h4>Conclusion</h4>Puerperal women were at a higher risk for serious outcomes (need for the ICU, need for invasive and noninvasive ventilatory support, and death) than pregnant women.Fabiano Elisei SerraRossana Pulcineli Vieira FranciscoPatricia de RossiMaria de Lourdes BrizotAgatha Sacramento RodriguesPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 16, Iss 11, p e0259911 (2021)
institution DOAJ
collection DOAJ
language EN
topic Medicine
R
Science
Q
spellingShingle Medicine
R
Science
Q
Fabiano Elisei Serra
Rossana Pulcineli Vieira Francisco
Patricia de Rossi
Maria de Lourdes Brizot
Agatha Sacramento Rodrigues
COVID-19 outcomes in hospitalized puerperal, pregnant, and neither pregnant nor puerperal women.
description <h4>Objective</h4>To compare hospitalized reproductive age women with COVID-19 who were pregnant, puerperal, or neither one nor the other in terms of demographic and clinical characteristics and disease progression using Brazilian epidemiological data.<h4>Methods</h4>A retrospective analysis of the records of the Information System of the Epidemiological Surveillance of Influenza of the Health Ministry of Brazil was performed. It included the data of female patients aged 10 to 49 years hospitalized because of severe COVID-19 disease (RT-PCR+ for SARS-CoV-2), from February 17, 2020 to January 02, 2021. They were separated into 3 groups: pregnant, puerperal, and neither pregnant nor puerperal. General comparisons and then adjustments for confounding variables (propensity score matching [PSM]) were made, using demographic and clinical characteristics, disease progression (admission to the intensive care unit [ICU] and invasive or noninvasive ventilatory support), and outcome (cure or death). Deaths were analyzed in each group according to comorbidities, invasive or noninvasive ventilatory support, and admission to the ICU.<h4>Results</h4>As many as 40,640 reproductive age women hospitalized for COVID-19 were identified: 3,372 were pregnant, 794 were puerperal, and 36,474 were neither pregnant nor puerperal. Groups were significantly different in terms of demographic data and comorbidities (p<0.0001). Pregnant and puerperal women were less likely to be symptomatic than the women who were neither one nor the other (72.1%, 69.7% and 88.8%, respectively). Pregnant women, however, had a higher frequency of anosmia, and ageusia than the others. After PSM, puerperal women had a worse prognosis than pregnant women with respect to admission to the ICU, invasive ventilatory support, and death, with OR (95% CI) 1.97 (1.55 - 2.50), 2.71 (1.78 - 4.13), and 2.51 (1.79 - 3.52), respectively.<h4>Conclusion</h4>Puerperal women were at a higher risk for serious outcomes (need for the ICU, need for invasive and noninvasive ventilatory support, and death) than pregnant women.
format article
author Fabiano Elisei Serra
Rossana Pulcineli Vieira Francisco
Patricia de Rossi
Maria de Lourdes Brizot
Agatha Sacramento Rodrigues
author_facet Fabiano Elisei Serra
Rossana Pulcineli Vieira Francisco
Patricia de Rossi
Maria de Lourdes Brizot
Agatha Sacramento Rodrigues
author_sort Fabiano Elisei Serra
title COVID-19 outcomes in hospitalized puerperal, pregnant, and neither pregnant nor puerperal women.
title_short COVID-19 outcomes in hospitalized puerperal, pregnant, and neither pregnant nor puerperal women.
title_full COVID-19 outcomes in hospitalized puerperal, pregnant, and neither pregnant nor puerperal women.
title_fullStr COVID-19 outcomes in hospitalized puerperal, pregnant, and neither pregnant nor puerperal women.
title_full_unstemmed COVID-19 outcomes in hospitalized puerperal, pregnant, and neither pregnant nor puerperal women.
title_sort covid-19 outcomes in hospitalized puerperal, pregnant, and neither pregnant nor puerperal women.
publisher Public Library of Science (PLoS)
publishDate 2021
url https://doaj.org/article/1c6780a501234b8c98d97a4f890f6415
work_keys_str_mv AT fabianoeliseiserra covid19outcomesinhospitalizedpuerperalpregnantandneitherpregnantnorpuerperalwomen
AT rossanapulcinelivieirafrancisco covid19outcomesinhospitalizedpuerperalpregnantandneitherpregnantnorpuerperalwomen
AT patriciaderossi covid19outcomesinhospitalizedpuerperalpregnantandneitherpregnantnorpuerperalwomen
AT mariadelourdesbrizot covid19outcomesinhospitalizedpuerperalpregnantandneitherpregnantnorpuerperalwomen
AT agathasacramentorodrigues covid19outcomesinhospitalizedpuerperalpregnantandneitherpregnantnorpuerperalwomen
_version_ 1718374452958330880