Relationships between serum Omentin-1 levels and bone mineral density in older men with osteoporosis

Objective: To investigate the correlation between serum Omentin-1 levels and the presence of osteoporosis in older men. Methods: Serum Omentin-1, bone turnover biochemical markers, and bone mineral density (BMD) were determined in 45 older men with osteoporosis or 45 older men without osteoporosis (...

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Autores principales:	Li Yang, Xin-Lan Zhao, Bin Liao, Ai-Ping Qin
Formato:	article
Lenguaje:	EN
Publicado:	KeAi Communications Co., Ltd. 2016
Materias:	Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/1c6be57e46fb41e88c1fabdeeece5070
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spelling	oai:doaj.org-article:1c6be57e46fb41e88c1fabdeeece50702021-12-02T13:25:24ZRelationships between serum Omentin-1 levels and bone mineral density in older men with osteoporosis2095-882X10.1016/j.cdtm.2016.02.003https://doaj.org/article/1c6be57e46fb41e88c1fabdeeece50702016-03-01T00:00:00Zhttp://www.sciencedirect.com/science/article/pii/S2095882X16000062https://doaj.org/toc/2095-882XObjective: To investigate the correlation between serum Omentin-1 levels and the presence of osteoporosis in older men. Methods: Serum Omentin-1, bone turnover biochemical markers, and bone mineral density (BMD) were determined in 45 older men with osteoporosis or 45 older men without osteoporosis (65â70 years old). Results: Omentin-1 levels were increased in older men with osteoporosis, and the differences remained significant after controlling for fat mass. Omentin-1 was negatively correlated with BMD. In a multiple linear stepwise regression analysis, Omentin-1, lean mass, but not fat mass, were independent predictors of BMD for the combined group. Significant negative correlations between Omentin-1 and bone-specific alkaline phosphatase (BAP) and bone cross-linked N-telopeptides of type â collagen (NTX) were found. Omentin-1 was also independently associated with BMD and bone turnover markers in older men with osteoporosis and control groups that were considered separately. Conclusions: Omentin-1 is an independent predictor of BMD in older men with osteoporosis, and it is negatively correlated with bone turnover biochemical markers. It is suggested that Omentin-1 may exert a negative effect on bone mass through the regulation of the osteoblast differentiation in the older men with osteoporosis. Keywords: Omentin-1, Bone mineral density, OsteoporosisLi YangXin-Lan ZhaoBin LiaoAi-Ping QinKeAi Communications Co., Ltd.articleMedicine (General)R5-920ENChronic Diseases and Translational Medicine, Vol 2, Iss 1, Pp 48-54 (2016)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine (General) R5-920
spellingShingle	Medicine (General) R5-920 Li Yang Xin-Lan Zhao Bin Liao Ai-Ping Qin Relationships between serum Omentin-1 levels and bone mineral density in older men with osteoporosis
description	Objective: To investigate the correlation between serum Omentin-1 levels and the presence of osteoporosis in older men. Methods: Serum Omentin-1, bone turnover biochemical markers, and bone mineral density (BMD) were determined in 45 older men with osteoporosis or 45 older men without osteoporosis (65â70 years old). Results: Omentin-1 levels were increased in older men with osteoporosis, and the differences remained significant after controlling for fat mass. Omentin-1 was negatively correlated with BMD. In a multiple linear stepwise regression analysis, Omentin-1, lean mass, but not fat mass, were independent predictors of BMD for the combined group. Significant negative correlations between Omentin-1 and bone-specific alkaline phosphatase (BAP) and bone cross-linked N-telopeptides of type â collagen (NTX) were found. Omentin-1 was also independently associated with BMD and bone turnover markers in older men with osteoporosis and control groups that were considered separately. Conclusions: Omentin-1 is an independent predictor of BMD in older men with osteoporosis, and it is negatively correlated with bone turnover biochemical markers. It is suggested that Omentin-1 may exert a negative effect on bone mass through the regulation of the osteoblast differentiation in the older men with osteoporosis. Keywords: Omentin-1, Bone mineral density, Osteoporosis
format	article
author	Li Yang Xin-Lan Zhao Bin Liao Ai-Ping Qin
author_facet	Li Yang Xin-Lan Zhao Bin Liao Ai-Ping Qin
author_sort	Li Yang
title	Relationships between serum Omentin-1 levels and bone mineral density in older men with osteoporosis
title_short	Relationships between serum Omentin-1 levels and bone mineral density in older men with osteoporosis
title_full	Relationships between serum Omentin-1 levels and bone mineral density in older men with osteoporosis
title_fullStr	Relationships between serum Omentin-1 levels and bone mineral density in older men with osteoporosis
title_full_unstemmed	Relationships between serum Omentin-1 levels and bone mineral density in older men with osteoporosis
title_sort	relationships between serum omentin-1 levels and bone mineral density in older men with osteoporosis
publisher	KeAi Communications Co., Ltd.
publishDate	2016
url	https://doaj.org/article/1c6be57e46fb41e88c1fabdeeece5070
work_keys_str_mv	AT liyang relationshipsbetweenserumomentin1levelsandbonemineraldensityinoldermenwithosteoporosis AT xinlanzhao relationshipsbetweenserumomentin1levelsandbonemineraldensityinoldermenwithosteoporosis AT binliao relationshipsbetweenserumomentin1levelsandbonemineraldensityinoldermenwithosteoporosis AT aipingqin relationshipsbetweenserumomentin1levelsandbonemineraldensityinoldermenwithosteoporosis
_version_	1718393017022283776

Relationships between serum Omentin-1 levels and bone mineral density in older men with osteoporosis

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