A real-world study of wearable sensors in Parkinson’s disease

Abstract Most wearable sensor studies in Parkinson’s disease have been conducted in the clinic and thus may not be a true representation of everyday symptoms and symptom variation. Our goal was to measure activity, gait, and tremor using wearable sensors inside and outside the clinic. In this observ...

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Autores principales:	Jamie L. Adams, Karthik Dinesh, Christopher W. Snyder, Mulin Xiong, Christopher G. Tarolli, Saloni Sharma, E. Ray Dorsey, Gaurav Sharma
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Neurology. Diseases of the nervous system RC346-429
Acceso en línea:	https://doaj.org/article/1c6f0d96b2ef49ff8d88adc23e47d3cb
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spelling	oai:doaj.org-article:1c6f0d96b2ef49ff8d88adc23e47d3cb2021-12-05T12:17:25ZA real-world study of wearable sensors in Parkinson’s disease10.1038/s41531-021-00248-w2373-8057https://doaj.org/article/1c6f0d96b2ef49ff8d88adc23e47d3cb2021-11-01T00:00:00Zhttps://doi.org/10.1038/s41531-021-00248-whttps://doaj.org/toc/2373-8057Abstract Most wearable sensor studies in Parkinson’s disease have been conducted in the clinic and thus may not be a true representation of everyday symptoms and symptom variation. Our goal was to measure activity, gait, and tremor using wearable sensors inside and outside the clinic. In this observational study, we assessed motor features using wearable sensors developed by MC10, Inc. Participants wore five sensors, one on each limb and on the trunk, during an in-person clinic visit and for two days thereafter. Using the accelerometer data from the sensors, activity states (lying, sitting, standing, walking) were determined and steps per day were also computed by aggregating over 2 s walking intervals. For non-walking periods, tremor durations were identified that had a characteristic frequency between 3 and 10 Hz. We analyzed data from 17 individuals with Parkinson’s disease and 17 age-matched controls over an average 45.4 h of sensor wear. Individuals with Parkinson’s walked significantly less (median [inter-quartile range]: 4980 [2835–7163] steps/day) than controls (7367 [5106–8928] steps/day; P = 0.04). Tremor was present for 1.6 [0.4–5.9] hours (median [range]) per day in most-affected hands (MDS-UPDRS 3.17a or 3.17b = 1–4) of individuals with Parkinson’s, which was significantly higher than the 0.5 [0.3–2.3] hours per day in less-affected hands (MDS-UPDRS 3.17a or 3.17b = 0). These results, which require replication in larger cohorts, advance our understanding of the manifestations of Parkinson’s in real-world settings.Jamie L. AdamsKarthik DineshChristopher W. SnyderMulin XiongChristopher G. TarolliSaloni SharmaE. Ray DorseyGaurav SharmaNature PortfolioarticleNeurology. Diseases of the nervous systemRC346-429ENnpj Parkinson's Disease, Vol 7, Iss 1, Pp 1-8 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Neurology. Diseases of the nervous system RC346-429
spellingShingle	Neurology. Diseases of the nervous system RC346-429 Jamie L. Adams Karthik Dinesh Christopher W. Snyder Mulin Xiong Christopher G. Tarolli Saloni Sharma E. Ray Dorsey Gaurav Sharma A real-world study of wearable sensors in Parkinson’s disease
description	Abstract Most wearable sensor studies in Parkinson’s disease have been conducted in the clinic and thus may not be a true representation of everyday symptoms and symptom variation. Our goal was to measure activity, gait, and tremor using wearable sensors inside and outside the clinic. In this observational study, we assessed motor features using wearable sensors developed by MC10, Inc. Participants wore five sensors, one on each limb and on the trunk, during an in-person clinic visit and for two days thereafter. Using the accelerometer data from the sensors, activity states (lying, sitting, standing, walking) were determined and steps per day were also computed by aggregating over 2 s walking intervals. For non-walking periods, tremor durations were identified that had a characteristic frequency between 3 and 10 Hz. We analyzed data from 17 individuals with Parkinson’s disease and 17 age-matched controls over an average 45.4 h of sensor wear. Individuals with Parkinson’s walked significantly less (median [inter-quartile range]: 4980 [2835–7163] steps/day) than controls (7367 [5106–8928] steps/day; P = 0.04). Tremor was present for 1.6 [0.4–5.9] hours (median [range]) per day in most-affected hands (MDS-UPDRS 3.17a or 3.17b = 1–4) of individuals with Parkinson’s, which was significantly higher than the 0.5 [0.3–2.3] hours per day in less-affected hands (MDS-UPDRS 3.17a or 3.17b = 0). These results, which require replication in larger cohorts, advance our understanding of the manifestations of Parkinson’s in real-world settings.
format	article
author	Jamie L. Adams Karthik Dinesh Christopher W. Snyder Mulin Xiong Christopher G. Tarolli Saloni Sharma E. Ray Dorsey Gaurav Sharma
author_facet	Jamie L. Adams Karthik Dinesh Christopher W. Snyder Mulin Xiong Christopher G. Tarolli Saloni Sharma E. Ray Dorsey Gaurav Sharma
author_sort	Jamie L. Adams
title	A real-world study of wearable sensors in Parkinson’s disease
title_short	A real-world study of wearable sensors in Parkinson’s disease
title_full	A real-world study of wearable sensors in Parkinson’s disease
title_fullStr	A real-world study of wearable sensors in Parkinson’s disease
title_full_unstemmed	A real-world study of wearable sensors in Parkinson’s disease
title_sort	real-world study of wearable sensors in parkinson’s disease
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/1c6f0d96b2ef49ff8d88adc23e47d3cb
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A real-world study of wearable sensors in Parkinson’s disease

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