Chemical control and insecticide resistance status of sand fly vectors worldwide.

<h4>Background</h4>Phlebotomine sand flies are prominent vectors of Leishmania parasites that cause leishmaniasis, which comes second to malaria in terms of parasitic causative fatalities globally. In the absence of human vaccines, sand fly chemical-based vector control is a key componen...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Sofia Balaska, Emmanouil Alexandros Fotakis, Alexandra Chaskopoulou, John Vontas
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2021
Materias:	Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270
Acceso en línea:	https://doaj.org/article/1c6fb89eaf87402086c542c9fbc22fd0
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:1c6fb89eaf87402086c542c9fbc22fd0
record_format	dspace
spelling	oai:doaj.org-article:1c6fb89eaf87402086c542c9fbc22fd02021-12-02T20:23:40ZChemical control and insecticide resistance status of sand fly vectors worldwide.1935-27271935-273510.1371/journal.pntd.0009586https://doaj.org/article/1c6fb89eaf87402086c542c9fbc22fd02021-08-01T00:00:00Zhttps://doi.org/10.1371/journal.pntd.0009586https://doaj.org/toc/1935-2727https://doaj.org/toc/1935-2735<h4>Background</h4>Phlebotomine sand flies are prominent vectors of Leishmania parasites that cause leishmaniasis, which comes second to malaria in terms of parasitic causative fatalities globally. In the absence of human vaccines, sand fly chemical-based vector control is a key component of leishmaniasis control efforts.<h4>Methods and findings</h4>We performed a literature review on the current interventions, primarily, insecticide-based used for sand fly control, as well as the global insecticide resistance (IR) status of the main sand fly vector species. Indoor insecticidal interventions, such as residual spraying and treated bed nets are the most widely deployed, while several alternative control strategies are also used in certain settings and/or are under evaluation. IR has been sporadically detected in sand flies in India and other regions, using non-standardized diagnostic bioassays. Molecular studies are limited to monitoring of known pyrethroid resistance mutations (kdr), which are present at high frequencies in certain regions.<h4>Conclusions</h4>As the leishmaniasis burden remains a major problem at a global scale, evidence-based rational use of insecticidal interventions is required to meet public health demands. Standardized bioassays and molecular markers are a prerequisite for this task, albeit are lagging behind. Experiences from other disease vectors underscore the need for the implementation of appropriate IR management (IRM) programs, in the framework of integrated vector management (IVM). The implementation of alternative strategies seems context- and case-specific, with key eco-epidemiological parameters yet to be investigated. New biotechnology-based control approaches might also come into play in the near future to further reinforce sand fly/leishmaniasis control efforts.Sofia BalaskaEmmanouil Alexandros FotakisAlexandra ChaskopoulouJohn VontasPublic Library of Science (PLoS)articleArctic medicine. Tropical medicineRC955-962Public aspects of medicineRA1-1270ENPLoS Neglected Tropical Diseases, Vol 15, Iss 8, p e0009586 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270
spellingShingle	Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 Sofia Balaska Emmanouil Alexandros Fotakis Alexandra Chaskopoulou John Vontas Chemical control and insecticide resistance status of sand fly vectors worldwide.
description	<h4>Background</h4>Phlebotomine sand flies are prominent vectors of Leishmania parasites that cause leishmaniasis, which comes second to malaria in terms of parasitic causative fatalities globally. In the absence of human vaccines, sand fly chemical-based vector control is a key component of leishmaniasis control efforts.<h4>Methods and findings</h4>We performed a literature review on the current interventions, primarily, insecticide-based used for sand fly control, as well as the global insecticide resistance (IR) status of the main sand fly vector species. Indoor insecticidal interventions, such as residual spraying and treated bed nets are the most widely deployed, while several alternative control strategies are also used in certain settings and/or are under evaluation. IR has been sporadically detected in sand flies in India and other regions, using non-standardized diagnostic bioassays. Molecular studies are limited to monitoring of known pyrethroid resistance mutations (kdr), which are present at high frequencies in certain regions.<h4>Conclusions</h4>As the leishmaniasis burden remains a major problem at a global scale, evidence-based rational use of insecticidal interventions is required to meet public health demands. Standardized bioassays and molecular markers are a prerequisite for this task, albeit are lagging behind. Experiences from other disease vectors underscore the need for the implementation of appropriate IR management (IRM) programs, in the framework of integrated vector management (IVM). The implementation of alternative strategies seems context- and case-specific, with key eco-epidemiological parameters yet to be investigated. New biotechnology-based control approaches might also come into play in the near future to further reinforce sand fly/leishmaniasis control efforts.
format	article
author	Sofia Balaska Emmanouil Alexandros Fotakis Alexandra Chaskopoulou John Vontas
author_facet	Sofia Balaska Emmanouil Alexandros Fotakis Alexandra Chaskopoulou John Vontas
author_sort	Sofia Balaska
title	Chemical control and insecticide resistance status of sand fly vectors worldwide.
title_short	Chemical control and insecticide resistance status of sand fly vectors worldwide.
title_full	Chemical control and insecticide resistance status of sand fly vectors worldwide.
title_fullStr	Chemical control and insecticide resistance status of sand fly vectors worldwide.
title_full_unstemmed	Chemical control and insecticide resistance status of sand fly vectors worldwide.
title_sort	chemical control and insecticide resistance status of sand fly vectors worldwide.
publisher	Public Library of Science (PLoS)
publishDate	2021
url	https://doaj.org/article/1c6fb89eaf87402086c542c9fbc22fd0
work_keys_str_mv	AT sofiabalaska chemicalcontrolandinsecticideresistancestatusofsandflyvectorsworldwide AT emmanouilalexandrosfotakis chemicalcontrolandinsecticideresistancestatusofsandflyvectorsworldwide AT alexandrachaskopoulou chemicalcontrolandinsecticideresistancestatusofsandflyvectorsworldwide AT johnvontas chemicalcontrolandinsecticideresistancestatusofsandflyvectorsworldwide
_version_	1718374093857751040

Chemical control and insecticide resistance status of sand fly vectors worldwide.

Ejemplares similares