Open questions: Reflections on intrinsically disordered proteins

Intrinsically Disordered Proteins or Regions (IDPs) are proteins that lack a predetermined 3D structure playing key cellular functions including regulation, signaling, and protein-protein/DNA interaction. IDPs are often involved in diseases such as cancer, cardiovascular and neurodegenerative diseas...

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Autores principales:	Mouna Choura, Ahmed Rebai
Formato:	article
Lenguaje:	EN
Publicado:	International Academy of Ecology and Environmental Sciences 2021
Materias:	disorder diseases protein regulation Biology (General) QH301-705.5
Acceso en línea:	https://doaj.org/article/1c7abac69acb43bda3a8baf276ca8faf
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spelling	oai:doaj.org-article:1c7abac69acb43bda3a8baf276ca8faf2021-11-17T03:24:38ZOpen questions: Reflections on intrinsically disordered proteins2220-8879https://doaj.org/article/1c7abac69acb43bda3a8baf276ca8faf2021-12-01T00:00:00Zhttp://www.iaees.org/publications/journals/nb/articles/2021-11(4)/reflections-on-intrinsically-disordered-proteins.pdfhttps://doaj.org/toc/2220-8879Intrinsically Disordered Proteins or Regions (IDPs) are proteins that lack a predetermined 3D structure playing key cellular functions including regulation, signaling, and protein-protein/DNA interaction. IDPs are often involved in diseases such as cancer, cardiovascular and neurodegenerative diseases, and diabetes. IDPs have been shown to be attractive therapeutic targets and drug development. Intrigued by these controversial observations, some questions are raised: how IDPs are so common even under the scenario that they are unstable and linked to misfolding and diseases? Does the cellular regulation depend on disorder? Mouna ChouraAhmed RebaiInternational Academy of Ecology and Environmental SciencesarticledisorderdiseasesproteinregulationBiology (General)QH301-705.5ENNetwork Biology, Vol 11, Iss 4, Pp 274-276 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	disorder diseases protein regulation Biology (General) QH301-705.5
spellingShingle	disorder diseases protein regulation Biology (General) QH301-705.5 Mouna Choura Ahmed Rebai Open questions: Reflections on intrinsically disordered proteins
description	Intrinsically Disordered Proteins or Regions (IDPs) are proteins that lack a predetermined 3D structure playing key cellular functions including regulation, signaling, and protein-protein/DNA interaction. IDPs are often involved in diseases such as cancer, cardiovascular and neurodegenerative diseases, and diabetes. IDPs have been shown to be attractive therapeutic targets and drug development. Intrigued by these controversial observations, some questions are raised: how IDPs are so common even under the scenario that they are unstable and linked to misfolding and diseases? Does the cellular regulation depend on disorder?
format	article
author	Mouna Choura Ahmed Rebai
author_facet	Mouna Choura Ahmed Rebai
author_sort	Mouna Choura
title	Open questions: Reflections on intrinsically disordered proteins
title_short	Open questions: Reflections on intrinsically disordered proteins
title_full	Open questions: Reflections on intrinsically disordered proteins
title_fullStr	Open questions: Reflections on intrinsically disordered proteins
title_full_unstemmed	Open questions: Reflections on intrinsically disordered proteins
title_sort	open questions: reflections on intrinsically disordered proteins
publisher	International Academy of Ecology and Environmental Sciences
publishDate	2021
url	https://doaj.org/article/1c7abac69acb43bda3a8baf276ca8faf
work_keys_str_mv	AT mounachoura openquestionsreflectionsonintrinsicallydisorderedproteins AT ahmedrebai openquestionsreflectionsonintrinsicallydisorderedproteins
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Open questions: Reflections on intrinsically disordered proteins

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