DIAGNOSTIC ACCURACY OF FIRST TRIMESTER HYPERURICEMIA FOR PREDICTION OF GESTATIONAL DIABETES MELLITUS

Objective: To find the diagnostic accuracy of first trimester hyperuricemia for the prediction of development of subsequent gestational diabetes mellitus. Study Design: Cross-sectional study. Place and Duration of Study: Conducted at department of Obstetrics & Gynaecology, Combined Militar...

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Autores principales:	Aiza Rehman, Saima Qamar, Humaira Osman Jaffery, Uzma Asif, Faiza Ibrar
Formato:	article
Lenguaje:	EN
Publicado:	Army Medical College Rawalpindi 2020
Materias:	diagnostic accuracy first trimester gestational diabetes mellitus hyperuricemia oral glucose tolerance test uric acid Medicine R Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/1c7b6e2679b8449d8ed674364a579091
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spelling	oai:doaj.org-article:1c7b6e2679b8449d8ed674364a5790912021-12-02T17:41:20ZDIAGNOSTIC ACCURACY OF FIRST TRIMESTER HYPERURICEMIA FOR PREDICTION OF GESTATIONAL DIABETES MELLITUS0030-96482411-8842https://doaj.org/article/1c7b6e2679b8449d8ed674364a5790912020-10-01T00:00:00Zhttps://pafmj.org/index.php/PAFMJ/article/view/5577https://doaj.org/toc/0030-9648https://doaj.org/toc/2411-8842Objective: To find the diagnostic accuracy of first trimester hyperuricemia for the prediction of development of subsequent gestational diabetes mellitus. Study Design: Cross-sectional study. Place and Duration of Study: Conducted at department of Obstetrics & Gynaecology, Combined Military Hospital Lahore, from Apr 2017 to Oct 2017. Methodology: All pregnant patients who met the inclusion criteria were enrolled in this study after informed consent. Blood samples in first trimester were collected for analysis of serum uric acid. Then after 24-28 weeks of gestation, Oral glucose tolerance test was done and presence of gestational diabetes mellitus was recorded. All the data were collected on a proforma. Results: The mean age of females was 26.70 ± 5.21 years. The mean height and weight was 1.62 ± 0.07 meters and 61.07 ± 8.54 kg respectively. Body mass index of patients was 23.32 ± 3.72 kg/m2. The mean gestational age of females was 9.96 ± 0.37 weeks at time of enrolment in the study. The mean uric acid level at time of presentation was 4.43 ± 3.61 mg/dl. In this study, the sensitivity and specificity of hyperuricemia for prediction of gestational diabetes mellitus were 91.1% and 95.7%. The positive predictive value and negative predictive value of hyperuricemia were 86.8% and 97.2% respectively. The overall diagnostic accuracy was 94.5%. Conclusion: Hyperuricemia in the first trimester is a reliable marker for prediction of gestational diabetes mellitus in later pregnancy.Aiza RehmanSaima QamarHumaira Osman JafferyUzma AsifFaiza IbrarArmy Medical College Rawalpindiarticlediagnostic accuracyfirst trimestergestational diabetes mellitushyperuricemiaoral glucose tolerance testuric acidMedicineRMedicine (General)R5-920ENPakistan Armed Forces Medical Journal, Vol 70, Iss 5, Pp 1586-1589 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	diagnostic accuracy first trimester gestational diabetes mellitus hyperuricemia oral glucose tolerance test uric acid Medicine R Medicine (General) R5-920
spellingShingle	diagnostic accuracy first trimester gestational diabetes mellitus hyperuricemia oral glucose tolerance test uric acid Medicine R Medicine (General) R5-920 Aiza Rehman Saima Qamar Humaira Osman Jaffery Uzma Asif Faiza Ibrar DIAGNOSTIC ACCURACY OF FIRST TRIMESTER HYPERURICEMIA FOR PREDICTION OF GESTATIONAL DIABETES MELLITUS
description	Objective: To find the diagnostic accuracy of first trimester hyperuricemia for the prediction of development of subsequent gestational diabetes mellitus. Study Design: Cross-sectional study. Place and Duration of Study: Conducted at department of Obstetrics & Gynaecology, Combined Military Hospital Lahore, from Apr 2017 to Oct 2017. Methodology: All pregnant patients who met the inclusion criteria were enrolled in this study after informed consent. Blood samples in first trimester were collected for analysis of serum uric acid. Then after 24-28 weeks of gestation, Oral glucose tolerance test was done and presence of gestational diabetes mellitus was recorded. All the data were collected on a proforma. Results: The mean age of females was 26.70 ± 5.21 years. The mean height and weight was 1.62 ± 0.07 meters and 61.07 ± 8.54 kg respectively. Body mass index of patients was 23.32 ± 3.72 kg/m2. The mean gestational age of females was 9.96 ± 0.37 weeks at time of enrolment in the study. The mean uric acid level at time of presentation was 4.43 ± 3.61 mg/dl. In this study, the sensitivity and specificity of hyperuricemia for prediction of gestational diabetes mellitus were 91.1% and 95.7%. The positive predictive value and negative predictive value of hyperuricemia were 86.8% and 97.2% respectively. The overall diagnostic accuracy was 94.5%. Conclusion: Hyperuricemia in the first trimester is a reliable marker for prediction of gestational diabetes mellitus in later pregnancy.
format	article
author	Aiza Rehman Saima Qamar Humaira Osman Jaffery Uzma Asif Faiza Ibrar
author_facet	Aiza Rehman Saima Qamar Humaira Osman Jaffery Uzma Asif Faiza Ibrar
author_sort	Aiza Rehman
title	DIAGNOSTIC ACCURACY OF FIRST TRIMESTER HYPERURICEMIA FOR PREDICTION OF GESTATIONAL DIABETES MELLITUS
title_short	DIAGNOSTIC ACCURACY OF FIRST TRIMESTER HYPERURICEMIA FOR PREDICTION OF GESTATIONAL DIABETES MELLITUS
title_full	DIAGNOSTIC ACCURACY OF FIRST TRIMESTER HYPERURICEMIA FOR PREDICTION OF GESTATIONAL DIABETES MELLITUS
title_fullStr	DIAGNOSTIC ACCURACY OF FIRST TRIMESTER HYPERURICEMIA FOR PREDICTION OF GESTATIONAL DIABETES MELLITUS
title_full_unstemmed	DIAGNOSTIC ACCURACY OF FIRST TRIMESTER HYPERURICEMIA FOR PREDICTION OF GESTATIONAL DIABETES MELLITUS
title_sort	diagnostic accuracy of first trimester hyperuricemia for prediction of gestational diabetes mellitus
publisher	Army Medical College Rawalpindi
publishDate	2020
url	https://doaj.org/article/1c7b6e2679b8449d8ed674364a579091
work_keys_str_mv	AT aizarehman diagnosticaccuracyoffirsttrimesterhyperuricemiaforpredictionofgestationaldiabetesmellitus AT saimaqamar diagnosticaccuracyoffirsttrimesterhyperuricemiaforpredictionofgestationaldiabetesmellitus AT humairaosmanjaffery diagnosticaccuracyoffirsttrimesterhyperuricemiaforpredictionofgestationaldiabetesmellitus AT uzmaasif diagnosticaccuracyoffirsttrimesterhyperuricemiaforpredictionofgestationaldiabetesmellitus AT faizaibrar diagnosticaccuracyoffirsttrimesterhyperuricemiaforpredictionofgestationaldiabetesmellitus
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DIAGNOSTIC ACCURACY OF FIRST TRIMESTER HYPERURICEMIA FOR PREDICTION OF GESTATIONAL DIABETES MELLITUS

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