Sex-specific expression of the X-linked histone demethylase gene Jarid1c in brain.

Jarid1c, an X-linked gene coding for a histone demethylase, plays an important role in brain development and function. Notably, JARID1C mutations cause mental retardation and increased aggression in humans. These phenotypes are consistent with the expression patterns we have identified in mouse brai...

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Autores principales:	Jun Xu, Xinxian Deng, Christine M Disteche
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2008
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/1c8083a70c88402089265023af476fe6
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spelling	oai:doaj.org-article:1c8083a70c88402089265023af476fe62021-11-25T06:11:49ZSex-specific expression of the X-linked histone demethylase gene Jarid1c in brain.1932-620310.1371/journal.pone.0002553https://doaj.org/article/1c8083a70c88402089265023af476fe62008-07-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/18596936/pdf/?tool=EBIhttps://doaj.org/toc/1932-6203Jarid1c, an X-linked gene coding for a histone demethylase, plays an important role in brain development and function. Notably, JARID1C mutations cause mental retardation and increased aggression in humans. These phenotypes are consistent with the expression patterns we have identified in mouse brain where Jarid1c mRNA was detected in hippocampus, hypothalamus, and cerebellum. Jarid1c expression and associated active histone marks at its 5'end are high in P19 neurons, indicating that JARID1C demethylase plays an important role in differentiated neuronal cells. We found that XX mice expressed Jarid1c more highly than XY mice, independent of their gonadal types (testes versus ovaries). This increased expression in XX mice is consistent with Jarid1c escape from X inactivation and is not compensated by expression from the Y-linked paralogue Jarid1d, which is expressed at a very low level compared to the X paralogue in P19 cells. Our observations suggest that sex-specific expression of Jarid1c may contribute to sex differences in brain function.Jun XuXinxian DengChristine M DistechePublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 3, Iss 7, p e2553 (2008)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Jun Xu Xinxian Deng Christine M Disteche Sex-specific expression of the X-linked histone demethylase gene Jarid1c in brain.
description	Jarid1c, an X-linked gene coding for a histone demethylase, plays an important role in brain development and function. Notably, JARID1C mutations cause mental retardation and increased aggression in humans. These phenotypes are consistent with the expression patterns we have identified in mouse brain where Jarid1c mRNA was detected in hippocampus, hypothalamus, and cerebellum. Jarid1c expression and associated active histone marks at its 5'end are high in P19 neurons, indicating that JARID1C demethylase plays an important role in differentiated neuronal cells. We found that XX mice expressed Jarid1c more highly than XY mice, independent of their gonadal types (testes versus ovaries). This increased expression in XX mice is consistent with Jarid1c escape from X inactivation and is not compensated by expression from the Y-linked paralogue Jarid1d, which is expressed at a very low level compared to the X paralogue in P19 cells. Our observations suggest that sex-specific expression of Jarid1c may contribute to sex differences in brain function.
format	article
author	Jun Xu Xinxian Deng Christine M Disteche
author_facet	Jun Xu Xinxian Deng Christine M Disteche
author_sort	Jun Xu
title	Sex-specific expression of the X-linked histone demethylase gene Jarid1c in brain.
title_short	Sex-specific expression of the X-linked histone demethylase gene Jarid1c in brain.
title_full	Sex-specific expression of the X-linked histone demethylase gene Jarid1c in brain.
title_fullStr	Sex-specific expression of the X-linked histone demethylase gene Jarid1c in brain.
title_full_unstemmed	Sex-specific expression of the X-linked histone demethylase gene Jarid1c in brain.
title_sort	sex-specific expression of the x-linked histone demethylase gene jarid1c in brain.
publisher	Public Library of Science (PLoS)
publishDate	2008
url	https://doaj.org/article/1c8083a70c88402089265023af476fe6
work_keys_str_mv	AT junxu sexspecificexpressionofthexlinkedhistonedemethylasegenejarid1cinbrain AT xinxiandeng sexspecificexpressionofthexlinkedhistonedemethylasegenejarid1cinbrain AT christinemdisteche sexspecificexpressionofthexlinkedhistonedemethylasegenejarid1cinbrain
_version_	1718414028854788096

Sex-specific expression of the X-linked histone demethylase gene Jarid1c in brain.

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