Contrast-associated acute kidney injury in patients with arterial hypertension and stable coronary artery disease

Relevance.The combination of stable coronary artery disease (CAD) and arterial hypertension (AH) is one of the most common seen by cardiologists. The administration of contrast media might increase the risk of development of acute kidney injury, especially in patients with comorbidities. The influen...

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Autores principales:	Olga Iu. Mironova, Viktor V. Fomin
Formato:	article
Lenguaje:	RU
Publicado:	IP Morozov P.V. 2020
Materias:	contrast-induced acute kidney injury contrast-induced nephropathy contrast-associated acute kidney injury coronary artery disease percutaneous coronary intervention arterial hypertension stable coronary artery disease prognosis Diseases of the circulatory (Cardiovascular) system RC666-701
Acceso en línea:	https://doaj.org/article/1c81a573ca76470eaae78589959e1214
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spelling	oai:doaj.org-article:1c81a573ca76470eaae78589959e12142021-11-30T16:09:16ZContrast-associated acute kidney injury in patients with arterial hypertension and stable coronary artery disease2075-082X2542-218910.26442/2075082X.2020.3.200337https://doaj.org/article/1c81a573ca76470eaae78589959e12142020-10-01T00:00:00Zhttps://syst-hypertension.ru/2075-082X/article/viewFile/43906/pdfhttps://doaj.org/toc/2075-082Xhttps://doaj.org/toc/2542-2189Relevance.The combination of stable coronary artery disease (CAD) and arterial hypertension (AH) is one of the most common seen by cardiologists. The administration of contrast media might increase the risk of development of acute kidney injury, especially in patients with comorbidities. The influence of iodine contrast media administration on the risk of development of contrast-associated acute kidney injury (CA-AKI) in patients with stable CAD and AH was studied in our work. Materials and methods.863 patients with stable CAD and AH and indications for interventions requiring intraarterial administration of contrast media were included in the prospective open observational cohort study (ClinicalTrials.gov ID NCT04014153). CA-AKI was defined according to KDIGO criteria as the elevation of serum creatinine 25% and more above baseline or 0.5 mg/dl (44 mkmol/l) and more in 48 hours after intraarterial administration of contrast media. The primary endpoint was the development of CA-AKI. Results.Diabetes mellitus, obesity and hyperuricemia were not statistically significant risk factors of CA-AKI development according to the contingency tables analyses, unlike proteinuria. A logistic regression model was built (area under the curve 0.7638,p0.0001, 95% confidence interval 0.7130.815) and included the following risk factors: age, weight, body mass index, female gender, heart failure, proteinuria, AH, anemia, baseline creatinine. Proteinuria, baseline creatinine and contrast volume were statistically significant ones. Conclusion.The rate of CA-AKI was 12.6%. Proteinuria, baseline creatinine and contrast volume were statistically significant risk factors of CA-AKI in logistic regression model. Key words:contrast-induced acute kidney injury, contrast-induced nephropathy, contrast-associated acute kidney injury, coronary artery disease, percutaneous coronary intervention, arterial hypertension, stable coronary artery disease, prognosis.Olga Iu. MironovaViktor V. FominIP Morozov P.V.articlecontrast-induced acute kidney injurycontrast-induced nephropathycontrast-associated acute kidney injurycoronary artery diseasepercutaneous coronary interventionarterial hypertensionstable coronary artery diseaseprognosisDiseases of the circulatory (Cardiovascular) systemRC666-701RUСистемные гипертензии, Vol 17, Iss 3, Pp 48-52 (2020)
institution	DOAJ
collection	DOAJ
language	RU
topic	contrast-induced acute kidney injury contrast-induced nephropathy contrast-associated acute kidney injury coronary artery disease percutaneous coronary intervention arterial hypertension stable coronary artery disease prognosis Diseases of the circulatory (Cardiovascular) system RC666-701
spellingShingle	contrast-induced acute kidney injury contrast-induced nephropathy contrast-associated acute kidney injury coronary artery disease percutaneous coronary intervention arterial hypertension stable coronary artery disease prognosis Diseases of the circulatory (Cardiovascular) system RC666-701 Olga Iu. Mironova Viktor V. Fomin Contrast-associated acute kidney injury in patients with arterial hypertension and stable coronary artery disease
description	Relevance.The combination of stable coronary artery disease (CAD) and arterial hypertension (AH) is one of the most common seen by cardiologists. The administration of contrast media might increase the risk of development of acute kidney injury, especially in patients with comorbidities. The influence of iodine contrast media administration on the risk of development of contrast-associated acute kidney injury (CA-AKI) in patients with stable CAD and AH was studied in our work. Materials and methods.863 patients with stable CAD and AH and indications for interventions requiring intraarterial administration of contrast media were included in the prospective open observational cohort study (ClinicalTrials.gov ID NCT04014153). CA-AKI was defined according to KDIGO criteria as the elevation of serum creatinine 25% and more above baseline or 0.5 mg/dl (44 mkmol/l) and more in 48 hours after intraarterial administration of contrast media. The primary endpoint was the development of CA-AKI. Results.Diabetes mellitus, obesity and hyperuricemia were not statistically significant risk factors of CA-AKI development according to the contingency tables analyses, unlike proteinuria. A logistic regression model was built (area under the curve 0.7638,p0.0001, 95% confidence interval 0.7130.815) and included the following risk factors: age, weight, body mass index, female gender, heart failure, proteinuria, AH, anemia, baseline creatinine. Proteinuria, baseline creatinine and contrast volume were statistically significant ones. Conclusion.The rate of CA-AKI was 12.6%. Proteinuria, baseline creatinine and contrast volume were statistically significant risk factors of CA-AKI in logistic regression model. Key words:contrast-induced acute kidney injury, contrast-induced nephropathy, contrast-associated acute kidney injury, coronary artery disease, percutaneous coronary intervention, arterial hypertension, stable coronary artery disease, prognosis.
format	article
author	Olga Iu. Mironova Viktor V. Fomin
author_facet	Olga Iu. Mironova Viktor V. Fomin
author_sort	Olga Iu. Mironova
title	Contrast-associated acute kidney injury in patients with arterial hypertension and stable coronary artery disease
title_short	Contrast-associated acute kidney injury in patients with arterial hypertension and stable coronary artery disease
title_full	Contrast-associated acute kidney injury in patients with arterial hypertension and stable coronary artery disease
title_fullStr	Contrast-associated acute kidney injury in patients with arterial hypertension and stable coronary artery disease
title_full_unstemmed	Contrast-associated acute kidney injury in patients with arterial hypertension and stable coronary artery disease
title_sort	contrast-associated acute kidney injury in patients with arterial hypertension and stable coronary artery disease
publisher	IP Morozov P.V.
publishDate	2020
url	https://doaj.org/article/1c81a573ca76470eaae78589959e1214
work_keys_str_mv	AT olgaiumironova contrastassociatedacutekidneyinjuryinpatientswitharterialhypertensionandstablecoronaryarterydisease AT viktorvfomin contrastassociatedacutekidneyinjuryinpatientswitharterialhypertensionandstablecoronaryarterydisease
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Contrast-associated acute kidney injury in patients with arterial hypertension and stable coronary artery disease

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