Occlusion of LTP-like plasticity in human primary motor cortex by action observation.

Passive observation of motor actions induces cortical activity in the primary motor cortex (M1) of the onlooker, which could potentially contribute to motor learning. While recent studies report modulation of motor performance following action observation, the neurophysiological mechanism supporting...

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Autores principales:	Jean-François Lepage, Olivier Morin-Moncet, Vincent Beaulé, Louis de Beaumont, Francois Champoux, Hugo Théoret
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2012
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/1c8225fe076f4a8e80f4119dbb26436c
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spelling	oai:doaj.org-article:1c8225fe076f4a8e80f4119dbb26436c2021-11-18T07:16:08ZOcclusion of LTP-like plasticity in human primary motor cortex by action observation.1932-620310.1371/journal.pone.0038754https://doaj.org/article/1c8225fe076f4a8e80f4119dbb26436c2012-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/22701704/?tool=EBIhttps://doaj.org/toc/1932-6203Passive observation of motor actions induces cortical activity in the primary motor cortex (M1) of the onlooker, which could potentially contribute to motor learning. While recent studies report modulation of motor performance following action observation, the neurophysiological mechanism supporting these behavioral changes remains to be specifically defined. Here, we assessed whether the observation of a repetitive thumb movement--similarly to active motor practice--would inhibit subsequent long-term potentiation-like (LTP) plasticity induced by paired-associative stimulation (PAS). Before undergoing PAS, participants were asked to either 1) perform abductions of the right thumb as fast as possible; 2) passively observe someone else perform thumb abductions; or 3) passively observe a moving dot mimicking thumb movements. Motor evoked potentials (MEP) were used to assess cortical excitability before and after motor practice (or observation) and at two time points following PAS. Results show that, similarly to participants in the motor practice group, individuals observing repeated motor actions showed marked inhibition of PAS-induced LTP, while the "moving dot" group displayed the expected increase in MEP amplitude, despite differences in baseline excitability. Interestingly, LTP occlusion in the action-observation group was present even if no increase in cortical excitability or movement speed was observed following observation. These results suggest that mere observation of repeated hand actions is sufficient to induce LTP, despite the absence of motor learning.Jean-François LepageOlivier Morin-MoncetVincent BeauléLouis de BeaumontFrancois ChampouxHugo ThéoretPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 7, Iss 6, p e38754 (2012)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Jean-François Lepage Olivier Morin-Moncet Vincent Beaulé Louis de Beaumont Francois Champoux Hugo Théoret Occlusion of LTP-like plasticity in human primary motor cortex by action observation.
description	Passive observation of motor actions induces cortical activity in the primary motor cortex (M1) of the onlooker, which could potentially contribute to motor learning. While recent studies report modulation of motor performance following action observation, the neurophysiological mechanism supporting these behavioral changes remains to be specifically defined. Here, we assessed whether the observation of a repetitive thumb movement--similarly to active motor practice--would inhibit subsequent long-term potentiation-like (LTP) plasticity induced by paired-associative stimulation (PAS). Before undergoing PAS, participants were asked to either 1) perform abductions of the right thumb as fast as possible; 2) passively observe someone else perform thumb abductions; or 3) passively observe a moving dot mimicking thumb movements. Motor evoked potentials (MEP) were used to assess cortical excitability before and after motor practice (or observation) and at two time points following PAS. Results show that, similarly to participants in the motor practice group, individuals observing repeated motor actions showed marked inhibition of PAS-induced LTP, while the "moving dot" group displayed the expected increase in MEP amplitude, despite differences in baseline excitability. Interestingly, LTP occlusion in the action-observation group was present even if no increase in cortical excitability or movement speed was observed following observation. These results suggest that mere observation of repeated hand actions is sufficient to induce LTP, despite the absence of motor learning.
format	article
author	Jean-François Lepage Olivier Morin-Moncet Vincent Beaulé Louis de Beaumont Francois Champoux Hugo Théoret
author_facet	Jean-François Lepage Olivier Morin-Moncet Vincent Beaulé Louis de Beaumont Francois Champoux Hugo Théoret
author_sort	Jean-François Lepage
title	Occlusion of LTP-like plasticity in human primary motor cortex by action observation.
title_short	Occlusion of LTP-like plasticity in human primary motor cortex by action observation.
title_full	Occlusion of LTP-like plasticity in human primary motor cortex by action observation.
title_fullStr	Occlusion of LTP-like plasticity in human primary motor cortex by action observation.
title_full_unstemmed	Occlusion of LTP-like plasticity in human primary motor cortex by action observation.
title_sort	occlusion of ltp-like plasticity in human primary motor cortex by action observation.
publisher	Public Library of Science (PLoS)
publishDate	2012
url	https://doaj.org/article/1c8225fe076f4a8e80f4119dbb26436c
work_keys_str_mv	AT jeanfrancoislepage occlusionofltplikeplasticityinhumanprimarymotorcortexbyactionobservation AT oliviermorinmoncet occlusionofltplikeplasticityinhumanprimarymotorcortexbyactionobservation AT vincentbeaule occlusionofltplikeplasticityinhumanprimarymotorcortexbyactionobservation AT louisdebeaumont occlusionofltplikeplasticityinhumanprimarymotorcortexbyactionobservation AT francoischampoux occlusionofltplikeplasticityinhumanprimarymotorcortexbyactionobservation AT hugotheoret occlusionofltplikeplasticityinhumanprimarymotorcortexbyactionobservation
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Occlusion of LTP-like plasticity in human primary motor cortex by action observation.

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