Association of GSTP1 Ile105Val polymorphism with the risk of coronary heart disease: An updated meta-analysis.

<h4>Background</h4>Numerous case-control studies have investigated the association between GSTP1 Ile105Val polymorphism and CHD risk, but the results from published studies were inconclusive. The present meta-analysis was performed to derive a more precise estimation.<h4>Methods<...

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Autores principales:	Yadong Song, Xiaoli Liu, Cheng Luo, Liangkai Chen, Lin Gong, Hanbin Yu, Bin Wang, Ernan Liu, Huiqiong Xu, Jiansheng Liang
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/1c838f3a9ce044fb8715189c321fe759
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spelling	oai:doaj.org-article:1c838f3a9ce044fb8715189c321fe7592021-12-02T20:06:38ZAssociation of GSTP1 Ile105Val polymorphism with the risk of coronary heart disease: An updated meta-analysis.1932-620310.1371/journal.pone.0254738https://doaj.org/article/1c838f3a9ce044fb8715189c321fe7592021-01-01T00:00:00Zhttps://doi.org/10.1371/journal.pone.0254738https://doaj.org/toc/1932-6203<h4>Background</h4>Numerous case-control studies have investigated the association between GSTP1 Ile105Val polymorphism and CHD risk, but the results from published studies were inconclusive. The present meta-analysis was performed to derive a more precise estimation.<h4>Methods</h4>PubMed, EMBASE, and Web of Science database searches were conducted to retrieve relevant articles.<h4>Results</h4>Ultimately, 5,451 CHD cases and 5,561 controls from 15 studies were included. Pooled analysis did not yield any statistically significant association between GSTP1 Ile105Val polymorphism and CHD risk for the overall population (Val vs. Ile: OR, 1.05; 95% CI, 0.93 to 1.18; Val/Val vs. Ile/Ile: OR, 1.09; 95% CI, 0.83 to 1.42; Val/Ile vs. Ile/Ile: OR, 1.09; 95% CI, 0.93 to 1.28; Val/Val vs. Val/Ile+Ile/Ile: OR, 1.04; 95% CI, 0.83 to 1.30; Val/Val+Val/Ile vs. Ile/Ile: OR, 1.14; 95% CI, 0.97 to 1.33). Subgroup analyses and sensitivity analyses indicated that GSTP1 Ile105Val polymorphism was still not associated with an increased risk of CHD. After excluding studies detected by Galbraith plots as major sources of heterogeneity, these relationships were still not significant.<h4>Conclusions</h4>The overall results did not reveal a major role of the GSTP1 Ile105Val polymorphism in modulating CHD risk. Well-designed studies with large sample sizes are needed to validate our findings and explore the possible gene-gene or gene-environment interactions.Yadong SongXiaoli LiuCheng LuoLiangkai ChenLin GongHanbin YuBin WangErnan LiuHuiqiong XuJiansheng LiangPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 16, Iss 7, p e0254738 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Yadong Song Xiaoli Liu Cheng Luo Liangkai Chen Lin Gong Hanbin Yu Bin Wang Ernan Liu Huiqiong Xu Jiansheng Liang Association of GSTP1 Ile105Val polymorphism with the risk of coronary heart disease: An updated meta-analysis.
description	<h4>Background</h4>Numerous case-control studies have investigated the association between GSTP1 Ile105Val polymorphism and CHD risk, but the results from published studies were inconclusive. The present meta-analysis was performed to derive a more precise estimation.<h4>Methods</h4>PubMed, EMBASE, and Web of Science database searches were conducted to retrieve relevant articles.<h4>Results</h4>Ultimately, 5,451 CHD cases and 5,561 controls from 15 studies were included. Pooled analysis did not yield any statistically significant association between GSTP1 Ile105Val polymorphism and CHD risk for the overall population (Val vs. Ile: OR, 1.05; 95% CI, 0.93 to 1.18; Val/Val vs. Ile/Ile: OR, 1.09; 95% CI, 0.83 to 1.42; Val/Ile vs. Ile/Ile: OR, 1.09; 95% CI, 0.93 to 1.28; Val/Val vs. Val/Ile+Ile/Ile: OR, 1.04; 95% CI, 0.83 to 1.30; Val/Val+Val/Ile vs. Ile/Ile: OR, 1.14; 95% CI, 0.97 to 1.33). Subgroup analyses and sensitivity analyses indicated that GSTP1 Ile105Val polymorphism was still not associated with an increased risk of CHD. After excluding studies detected by Galbraith plots as major sources of heterogeneity, these relationships were still not significant.<h4>Conclusions</h4>The overall results did not reveal a major role of the GSTP1 Ile105Val polymorphism in modulating CHD risk. Well-designed studies with large sample sizes are needed to validate our findings and explore the possible gene-gene or gene-environment interactions.
format	article
author	Yadong Song Xiaoli Liu Cheng Luo Liangkai Chen Lin Gong Hanbin Yu Bin Wang Ernan Liu Huiqiong Xu Jiansheng Liang
author_facet	Yadong Song Xiaoli Liu Cheng Luo Liangkai Chen Lin Gong Hanbin Yu Bin Wang Ernan Liu Huiqiong Xu Jiansheng Liang
author_sort	Yadong Song
title	Association of GSTP1 Ile105Val polymorphism with the risk of coronary heart disease: An updated meta-analysis.
title_short	Association of GSTP1 Ile105Val polymorphism with the risk of coronary heart disease: An updated meta-analysis.
title_full	Association of GSTP1 Ile105Val polymorphism with the risk of coronary heart disease: An updated meta-analysis.
title_fullStr	Association of GSTP1 Ile105Val polymorphism with the risk of coronary heart disease: An updated meta-analysis.
title_full_unstemmed	Association of GSTP1 Ile105Val polymorphism with the risk of coronary heart disease: An updated meta-analysis.
title_sort	association of gstp1 ile105val polymorphism with the risk of coronary heart disease: an updated meta-analysis.
publisher	Public Library of Science (PLoS)
publishDate	2021
url	https://doaj.org/article/1c838f3a9ce044fb8715189c321fe759
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Association of GSTP1 Ile105Val polymorphism with the risk of coronary heart disease: An updated meta-analysis.

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