Associations of Gain in Weight-Related Anthropometric Indices with a Marker of Lipid Peroxidation: A Cohort Study Among Urban Adults in China

Tao Xu,1,2 Bin Wang,1,2 Limin Cao,1,2 Weihong Qiu,1,2 Zhuang Zhang,1,2 Ailian Chen,1,2 Weihong Chen1,2 1Department of Occupational and Environmental Health, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei 430030, People’s Republi...

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Autores principales:	Xu T, Wang B, Cao L, Qiu W, Zhang Z, Chen A, Chen W
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2020
Materias:	weight-related anthropometric indices lipid peroxidation obesity cohort study Specialties of internal medicine RC581-951
Acceso en línea:	https://doaj.org/article/1c86cc8df42f4267af98db8ed0bdd818
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spelling	oai:doaj.org-article:1c86cc8df42f4267af98db8ed0bdd8182021-12-02T11:25:03ZAssociations of Gain in Weight-Related Anthropometric Indices with a Marker of Lipid Peroxidation: A Cohort Study Among Urban Adults in China1178-7007https://doaj.org/article/1c86cc8df42f4267af98db8ed0bdd8182020-08-01T00:00:00Zhttps://www.dovepress.com/associations-of-gain-in-weight-related-anthropometric-indices-with-a-m-peer-reviewed-article-DMSOhttps://doaj.org/toc/1178-7007Tao Xu,1,2 Bin Wang,1,2 Limin Cao,1,2 Weihong Qiu,1,2 Zhuang Zhang,1,2 Ailian Chen,1,2 Weihong Chen1,2 1Department of Occupational and Environmental Health, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei 430030, People’s Republic of China; 2Key Laboratory of Environment and Health, Ministry of Education and Ministry of Environmental Protection, State Key Laboratory of Environmental Health (Incubating), School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei 430030, People’s Republic of ChinaCorrespondence: Weihong ChenDepartment of Occupational and Environmental Health, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei 430030, People’s Republic of ChinaTel +86 27 83691677Email wchen@mails.tjmu.edu.cnBackground: Obesity is reported to be associated with oxidative stress which can cause lipid peroxidation. However, the effects of gain in various weight-related anthropometric indices on lipid peroxidation remain unclear. We aimed to examine the cross-sectional and longitudinal associations between altered weight-related anthropometric indices and a marker of lipid peroxidation among urban adults in China.Methods: A total of 3762 participants from the Wuhan-Zhuhai cohort were included in the present study, with a follow-up of 3 years. Six weight-related anthropometric indicators were measured and calculated, including waist circumference (WC), body mass index (BMI), waist-to-hip ratio (WHR), waist-to-height ratio (WHtR), a body shape index (ABSI), and body adiposity index (BAI). Individual urinary 8-iso-prostaglandin-F2α (8-iso-PGF2α) was determined via enzyme-linked immunosorbent assay to evaluate lipid peroxidation. We used generalized linear models to analyze the cross-sectional and longitudinal associations of weight-related anthropometric indices with a marker of lipid peroxidation and stratified analyses to estimate effect modification.Results: We found significant relationships between WHR, WHtR, ABSI, and urinary 8-iso-PGF2α at baseline. Each 1% increase in WHR, WHtR, and ABSI was significantly associated with a 0.007, 0.004, and 0.104 increase in log-transformed 8-iso-PGF2α concentration, respectively (P< 0.05). In longitudinal analysis, positive dose–response relationships were observed between gains in BMI, BAI, and increased 8-iso-PGF2α after adjusting for potential confounders (Ptrend< 0.05). We also found that gender and smoking status modified the association of BMI gain and 8-iso-PGF2α increment, and such an association was more obvious in female and non-smokers.Conclusion: Our research implied that gain in anthropometric indices may result in a higher level of lipid peroxidation.Keywords: weight-related anthropometric indices, lipid peroxidation, obesity, cohort studyXu TWang BCao LQiu WZhang ZChen AChen WDove Medical Pressarticleweight-related anthropometric indiceslipid peroxidationobesitycohort studySpecialties of internal medicineRC581-951ENDiabetes, Metabolic Syndrome and Obesity: Targets and Therapy, Vol Volume 13, Pp 2877-2887 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	weight-related anthropometric indices lipid peroxidation obesity cohort study Specialties of internal medicine RC581-951
spellingShingle	weight-related anthropometric indices lipid peroxidation obesity cohort study Specialties of internal medicine RC581-951 Xu T Wang B Cao L Qiu W Zhang Z Chen A Chen W Associations of Gain in Weight-Related Anthropometric Indices with a Marker of Lipid Peroxidation: A Cohort Study Among Urban Adults in China
description	Tao Xu,1,2 Bin Wang,1,2 Limin Cao,1,2 Weihong Qiu,1,2 Zhuang Zhang,1,2 Ailian Chen,1,2 Weihong Chen1,2 1Department of Occupational and Environmental Health, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei 430030, People’s Republic of China; 2Key Laboratory of Environment and Health, Ministry of Education and Ministry of Environmental Protection, State Key Laboratory of Environmental Health (Incubating), School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei 430030, People’s Republic of ChinaCorrespondence: Weihong ChenDepartment of Occupational and Environmental Health, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei 430030, People’s Republic of ChinaTel +86 27 83691677Email wchen@mails.tjmu.edu.cnBackground: Obesity is reported to be associated with oxidative stress which can cause lipid peroxidation. However, the effects of gain in various weight-related anthropometric indices on lipid peroxidation remain unclear. We aimed to examine the cross-sectional and longitudinal associations between altered weight-related anthropometric indices and a marker of lipid peroxidation among urban adults in China.Methods: A total of 3762 participants from the Wuhan-Zhuhai cohort were included in the present study, with a follow-up of 3 years. Six weight-related anthropometric indicators were measured and calculated, including waist circumference (WC), body mass index (BMI), waist-to-hip ratio (WHR), waist-to-height ratio (WHtR), a body shape index (ABSI), and body adiposity index (BAI). Individual urinary 8-iso-prostaglandin-F2α (8-iso-PGF2α) was determined via enzyme-linked immunosorbent assay to evaluate lipid peroxidation. We used generalized linear models to analyze the cross-sectional and longitudinal associations of weight-related anthropometric indices with a marker of lipid peroxidation and stratified analyses to estimate effect modification.Results: We found significant relationships between WHR, WHtR, ABSI, and urinary 8-iso-PGF2α at baseline. Each 1% increase in WHR, WHtR, and ABSI was significantly associated with a 0.007, 0.004, and 0.104 increase in log-transformed 8-iso-PGF2α concentration, respectively (P< 0.05). In longitudinal analysis, positive dose–response relationships were observed between gains in BMI, BAI, and increased 8-iso-PGF2α after adjusting for potential confounders (Ptrend< 0.05). We also found that gender and smoking status modified the association of BMI gain and 8-iso-PGF2α increment, and such an association was more obvious in female and non-smokers.Conclusion: Our research implied that gain in anthropometric indices may result in a higher level of lipid peroxidation.Keywords: weight-related anthropometric indices, lipid peroxidation, obesity, cohort study
format	article
author	Xu T Wang B Cao L Qiu W Zhang Z Chen A Chen W
author_facet	Xu T Wang B Cao L Qiu W Zhang Z Chen A Chen W
author_sort	Xu T
title	Associations of Gain in Weight-Related Anthropometric Indices with a Marker of Lipid Peroxidation: A Cohort Study Among Urban Adults in China
title_short	Associations of Gain in Weight-Related Anthropometric Indices with a Marker of Lipid Peroxidation: A Cohort Study Among Urban Adults in China
title_full	Associations of Gain in Weight-Related Anthropometric Indices with a Marker of Lipid Peroxidation: A Cohort Study Among Urban Adults in China
title_fullStr	Associations of Gain in Weight-Related Anthropometric Indices with a Marker of Lipid Peroxidation: A Cohort Study Among Urban Adults in China
title_full_unstemmed	Associations of Gain in Weight-Related Anthropometric Indices with a Marker of Lipid Peroxidation: A Cohort Study Among Urban Adults in China
title_sort	associations of gain in weight-related anthropometric indices with a marker of lipid peroxidation: a cohort study among urban adults in china
publisher	Dove Medical Press
publishDate	2020
url	https://doaj.org/article/1c86cc8df42f4267af98db8ed0bdd818
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Associations of Gain in Weight-Related Anthropometric Indices with a Marker of Lipid Peroxidation: A Cohort Study Among Urban Adults in China

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