The Effect of Antlion (Myrmeleon sp.) Extract Towards Histopathology Image of Pancreas in Diabetic Mice

Introduction: Some studies indicated that antlions (Myrmeleon sp.) is traditionally used by many people in Indonesia as a diabetes treatmenter. However. reseach has not been done to find the effect of antlion extract in pancreas, an important organ in diabetes mellitus pathophysiology. Objective: To...

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Autores principales:	Muhammad Naufal Widyatmaka, Akhmad Ismail
Formato:	article
Lenguaje:	EN
Publicado:	Universitas Sultan Agung Semarang 2021
Materias:	streptozotocine, islet damage, tissue repair Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/1c879610a3c74b9fbdf82ee72d31bc1a
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spelling	oai:doaj.org-article:1c879610a3c74b9fbdf82ee72d31bc1a2021-11-25T13:16:44ZThe Effect of Antlion (Myrmeleon sp.) Extract Towards Histopathology Image of Pancreas in Diabetic Mice2085-15452339-093X10.30659/sainsmed.v11i2.7656https://doaj.org/article/1c879610a3c74b9fbdf82ee72d31bc1a2021-01-01T00:00:00Zhttp://jurnal.unissula.ac.id/index.php/sainsmedika/article/view/7656https://doaj.org/toc/2085-1545https://doaj.org/toc/2339-093XIntroduction: Some studies indicated that antlions (Myrmeleon sp.) is traditionally used by many people in Indonesia as a diabetes treatmenter. However. reseach has not been done to find the effect of antlion extract in pancreas, an important organ in diabetes mellitus pathophysiology. Objective: To prove the effect of antlion extract towards histopathological feature of pancreas in diabetic mice. Methods: In the post test only control group design, 25 Swiss mice were divided into five groups. Normal group (Nor-G), Negative control group (Neg-G), and the other 3 groups were intraperitoneally injected with Streptozotocine 200 mg/kg to induce diabetic state. In Neg-G had no antlion treatment, whereas in At-14, At-28, and At-56 were treated with antlion extract at the dose of 14, 28, and 56 mg/kg BW respectively for 24 days. Pancreas then collected and prepared to be examined under microscope with 400x magnification. The score of pancreatic islet injury was determined by assessing structural damage and inflammatory cells infiltration. Kruskal-Wallis and Mann-Whitney were adopted as statistical analysis. Results: Mann-Whitney analysis indicated that the score of pancreatic islets injury in At-56 was significant lower compared to that of Neg-G, p<0.05. The score of pancreatic islets injury in At-56 also significant lower compared to that of At-14 and At-28, p<0.05. In contrary, when compared to that of Nor-G, the pancreatic islets injury in At-56 was not signicantly lower, p>0.05. Conclusion: Antlion extract treatment at the dose of 56 mg/kg BW was capable of reducing pancreatic islet injury in diabetic mice induced by streptozotocine.Muhammad Naufal WidyatmakaAkhmad IsmailUniversitas Sultan Agung Semarangarticlestreptozotocine, islet damage, tissue repairMedicine (General)R5-920ENSains Medika, Vol 11, Iss 2, Pp 48-53 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	streptozotocine, islet damage, tissue repair Medicine (General) R5-920
spellingShingle	streptozotocine, islet damage, tissue repair Medicine (General) R5-920 Muhammad Naufal Widyatmaka Akhmad Ismail The Effect of Antlion (Myrmeleon sp.) Extract Towards Histopathology Image of Pancreas in Diabetic Mice
description	Introduction: Some studies indicated that antlions (Myrmeleon sp.) is traditionally used by many people in Indonesia as a diabetes treatmenter. However. reseach has not been done to find the effect of antlion extract in pancreas, an important organ in diabetes mellitus pathophysiology. Objective: To prove the effect of antlion extract towards histopathological feature of pancreas in diabetic mice. Methods: In the post test only control group design, 25 Swiss mice were divided into five groups. Normal group (Nor-G), Negative control group (Neg-G), and the other 3 groups were intraperitoneally injected with Streptozotocine 200 mg/kg to induce diabetic state. In Neg-G had no antlion treatment, whereas in At-14, At-28, and At-56 were treated with antlion extract at the dose of 14, 28, and 56 mg/kg BW respectively for 24 days. Pancreas then collected and prepared to be examined under microscope with 400x magnification. The score of pancreatic islet injury was determined by assessing structural damage and inflammatory cells infiltration. Kruskal-Wallis and Mann-Whitney were adopted as statistical analysis. Results: Mann-Whitney analysis indicated that the score of pancreatic islets injury in At-56 was significant lower compared to that of Neg-G, p<0.05. The score of pancreatic islets injury in At-56 also significant lower compared to that of At-14 and At-28, p<0.05. In contrary, when compared to that of Nor-G, the pancreatic islets injury in At-56 was not signicantly lower, p>0.05. Conclusion: Antlion extract treatment at the dose of 56 mg/kg BW was capable of reducing pancreatic islet injury in diabetic mice induced by streptozotocine.
format	article
author	Muhammad Naufal Widyatmaka Akhmad Ismail
author_facet	Muhammad Naufal Widyatmaka Akhmad Ismail
author_sort	Muhammad Naufal Widyatmaka
title	The Effect of Antlion (Myrmeleon sp.) Extract Towards Histopathology Image of Pancreas in Diabetic Mice
title_short	The Effect of Antlion (Myrmeleon sp.) Extract Towards Histopathology Image of Pancreas in Diabetic Mice
title_full	The Effect of Antlion (Myrmeleon sp.) Extract Towards Histopathology Image of Pancreas in Diabetic Mice
title_fullStr	The Effect of Antlion (Myrmeleon sp.) Extract Towards Histopathology Image of Pancreas in Diabetic Mice
title_full_unstemmed	The Effect of Antlion (Myrmeleon sp.) Extract Towards Histopathology Image of Pancreas in Diabetic Mice
title_sort	effect of antlion (myrmeleon sp.) extract towards histopathology image of pancreas in diabetic mice
publisher	Universitas Sultan Agung Semarang
publishDate	2021
url	https://doaj.org/article/1c879610a3c74b9fbdf82ee72d31bc1a
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The Effect of Antlion (Myrmeleon sp.) Extract Towards Histopathology Image of Pancreas in Diabetic Mice

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