ALDH7A1 inhibits the intracellular transport pathways during hypoxia and starvation to promote cellular energy homeostasis

Intracellular vesicle transport can be regulated by Brefeldin‐A ADP‐Ribosylated Substrate (BARS) during vesicle fission. Here, the authors show that NADH generated by aldehyde dehydrogenase 7A1 (ALDH7A1) inhibits intracellular transport by targeting BARS and inhibiting COPI vesicle fission during si...

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Autores principales:	Jia-Shu Yang, Jia-Wei Hsu, Seung-Yeol Park, Stella Y. Lee, Jian Li, Ming Bai, Claudia Alves, William Tseng, Xavier Michelet, I-Cheng Ho, Victor W. Hsu
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2019
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/1c893257dab047c3a63455ff031c0ff7
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

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spelling	oai:doaj.org-article:1c893257dab047c3a63455ff031c0ff72021-12-02T17:01:44ZALDH7A1 inhibits the intracellular transport pathways during hypoxia and starvation to promote cellular energy homeostasis10.1038/s41467-019-11932-02041-1723https://doaj.org/article/1c893257dab047c3a63455ff031c0ff72019-09-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-11932-0https://doaj.org/toc/2041-1723Intracellular vesicle transport can be regulated by Brefeldin‐A ADP‐Ribosylated Substrate (BARS) during vesicle fission. Here, the authors show that NADH generated by aldehyde dehydrogenase 7A1 (ALDH7A1) inhibits intracellular transport by targeting BARS and inhibiting COPI vesicle fission during situations of energy deprivationJia-Shu YangJia-Wei HsuSeung-Yeol ParkStella Y. LeeJian LiMing BaiClaudia AlvesWilliam TsengXavier MicheletI-Cheng HoVictor W. HsuNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-16 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Jia-Shu Yang Jia-Wei Hsu Seung-Yeol Park Stella Y. Lee Jian Li Ming Bai Claudia Alves William Tseng Xavier Michelet I-Cheng Ho Victor W. Hsu ALDH7A1 inhibits the intracellular transport pathways during hypoxia and starvation to promote cellular energy homeostasis
description	Intracellular vesicle transport can be regulated by Brefeldin‐A ADP‐Ribosylated Substrate (BARS) during vesicle fission. Here, the authors show that NADH generated by aldehyde dehydrogenase 7A1 (ALDH7A1) inhibits intracellular transport by targeting BARS and inhibiting COPI vesicle fission during situations of energy deprivation
format	article
author	Jia-Shu Yang Jia-Wei Hsu Seung-Yeol Park Stella Y. Lee Jian Li Ming Bai Claudia Alves William Tseng Xavier Michelet I-Cheng Ho Victor W. Hsu
author_facet	Jia-Shu Yang Jia-Wei Hsu Seung-Yeol Park Stella Y. Lee Jian Li Ming Bai Claudia Alves William Tseng Xavier Michelet I-Cheng Ho Victor W. Hsu
author_sort	Jia-Shu Yang
title	ALDH7A1 inhibits the intracellular transport pathways during hypoxia and starvation to promote cellular energy homeostasis
title_short	ALDH7A1 inhibits the intracellular transport pathways during hypoxia and starvation to promote cellular energy homeostasis
title_full	ALDH7A1 inhibits the intracellular transport pathways during hypoxia and starvation to promote cellular energy homeostasis
title_fullStr	ALDH7A1 inhibits the intracellular transport pathways during hypoxia and starvation to promote cellular energy homeostasis
title_full_unstemmed	ALDH7A1 inhibits the intracellular transport pathways during hypoxia and starvation to promote cellular energy homeostasis
title_sort	aldh7a1 inhibits the intracellular transport pathways during hypoxia and starvation to promote cellular energy homeostasis
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/1c893257dab047c3a63455ff031c0ff7
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ALDH7A1 inhibits the intracellular transport pathways during hypoxia and starvation to promote cellular energy homeostasis

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