Periodontal disease and risk of head and neck cancer: a meta-analysis of observational studies.

<h4>Background</h4>Many epidemiological studies have found a positive association of periodontal disease (PD) with risk of head and neck cancer (HNC), but the findings are varied or even contradictory. In this work, we performed a meta-analysis to ascertain the relationship between PD an...

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Autores principales:	Xian-Tao Zeng, Ai-Ping Deng, Cheng Li, Ling-Yun Xia, Yu-Ming Niu, Wei-Dong Leng
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2013
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/1c89e00d529446afb845e51025ee6bae
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spelling	oai:doaj.org-article:1c89e00d529446afb845e51025ee6bae2021-11-18T08:49:41ZPeriodontal disease and risk of head and neck cancer: a meta-analysis of observational studies.1932-620310.1371/journal.pone.0079017https://doaj.org/article/1c89e00d529446afb845e51025ee6bae2013-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/24194957/?tool=EBIhttps://doaj.org/toc/1932-6203<h4>Background</h4>Many epidemiological studies have found a positive association of periodontal disease (PD) with risk of head and neck cancer (HNC), but the findings are varied or even contradictory. In this work, we performed a meta-analysis to ascertain the relationship between PD and HNC risk.<h4>Methods</h4>We searched the PubMed, Embase, and Cochrane Library databases for relevant observational studies on the association between PD and HNC risk published up to March 23, 2013. Data from the included studies were extracted and analyzed independently by two authors. Meta-analysis was performed using RevMan 5.2 software.<h4>Results</h4>We obtained seven observational studies involving two cohort and six case-control studies. Random-effects meta-analysis indicated a significant association between PD and HNC risk (odds ratio = 2.63, 95% confidence interval = 1.1.68 - 4.14; p < 0.001), with sensitivity analysis showing that the result was robust. Subgroup analyses based on adjustment for covariates, study design, PD assessment, tumor site, and ethnicity also revealed a significant association.<h4>Conclusions</h4>Based on currently evidence, PD is probably a significant and independent risk factor of HNC.Xian-Tao ZengAi-Ping DengCheng LiLing-Yun XiaYu-Ming NiuWei-Dong LengPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 8, Iss 10, p e79017 (2013)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Xian-Tao Zeng Ai-Ping Deng Cheng Li Ling-Yun Xia Yu-Ming Niu Wei-Dong Leng Periodontal disease and risk of head and neck cancer: a meta-analysis of observational studies.
description	<h4>Background</h4>Many epidemiological studies have found a positive association of periodontal disease (PD) with risk of head and neck cancer (HNC), but the findings are varied or even contradictory. In this work, we performed a meta-analysis to ascertain the relationship between PD and HNC risk.<h4>Methods</h4>We searched the PubMed, Embase, and Cochrane Library databases for relevant observational studies on the association between PD and HNC risk published up to March 23, 2013. Data from the included studies were extracted and analyzed independently by two authors. Meta-analysis was performed using RevMan 5.2 software.<h4>Results</h4>We obtained seven observational studies involving two cohort and six case-control studies. Random-effects meta-analysis indicated a significant association between PD and HNC risk (odds ratio = 2.63, 95% confidence interval = 1.1.68 - 4.14; p < 0.001), with sensitivity analysis showing that the result was robust. Subgroup analyses based on adjustment for covariates, study design, PD assessment, tumor site, and ethnicity also revealed a significant association.<h4>Conclusions</h4>Based on currently evidence, PD is probably a significant and independent risk factor of HNC.
format	article
author	Xian-Tao Zeng Ai-Ping Deng Cheng Li Ling-Yun Xia Yu-Ming Niu Wei-Dong Leng
author_facet	Xian-Tao Zeng Ai-Ping Deng Cheng Li Ling-Yun Xia Yu-Ming Niu Wei-Dong Leng
author_sort	Xian-Tao Zeng
title	Periodontal disease and risk of head and neck cancer: a meta-analysis of observational studies.
title_short	Periodontal disease and risk of head and neck cancer: a meta-analysis of observational studies.
title_full	Periodontal disease and risk of head and neck cancer: a meta-analysis of observational studies.
title_fullStr	Periodontal disease and risk of head and neck cancer: a meta-analysis of observational studies.
title_full_unstemmed	Periodontal disease and risk of head and neck cancer: a meta-analysis of observational studies.
title_sort	periodontal disease and risk of head and neck cancer: a meta-analysis of observational studies.
publisher	Public Library of Science (PLoS)
publishDate	2013
url	https://doaj.org/article/1c89e00d529446afb845e51025ee6bae
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Periodontal disease and risk of head and neck cancer: a meta-analysis of observational studies.

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