Development of an HPTLC-based dynamic reference standard for the analysis of complex natural products using Jarrah honey as test sample.

In this paper, we describe a novel approach to the development of a reference standard for the quality control of complex natural products, which will assist in the assessment of their authenticity and purity. The proposed method provides a template for the selection of samples, which can be pooled...

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Autores principales:	Md Khairul Islam, Tomislav Sostaric, Lee Yong Lim, Katherine Hammer, Cornelia Locher
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/1c89e3d7f27d4cdba90832a588c78b00
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id	oai:doaj.org-article:1c89e3d7f27d4cdba90832a588c78b00
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spelling	oai:doaj.org-article:1c89e3d7f27d4cdba90832a588c78b002021-12-02T20:06:47ZDevelopment of an HPTLC-based dynamic reference standard for the analysis of complex natural products using Jarrah honey as test sample.1932-620310.1371/journal.pone.0254857https://doaj.org/article/1c89e3d7f27d4cdba90832a588c78b002021-01-01T00:00:00Zhttps://doi.org/10.1371/journal.pone.0254857https://doaj.org/toc/1932-6203In this paper, we describe a novel approach to the development of a reference standard for the quality control of complex natural products, which will assist in the assessment of their authenticity and purity. The proposed method provides a template for the selection of samples, which can be pooled to obtain a reference standard. A shortfall of such an approach is, however, that the pooled sample is static in nature and therefore unable to capture difference in processing conditions or natural variations triggered by geographical or climatic impacts over time. To address this, the paper also outlines the development of a dynamic reference standard, which allows for ongoing adjustments to future variations. The method employs High-Performance Thin Layer Chromatography (HPTLC) derived extract profiles processed by multivariate analysis. The development of the dynamic reference standard is illustrated using honey, a complex natural matrix, as an example.Md Khairul IslamTomislav SostaricLee Yong LimKatherine HammerCornelia LocherPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 16, Iss 7, p e0254857 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Md Khairul Islam Tomislav Sostaric Lee Yong Lim Katherine Hammer Cornelia Locher Development of an HPTLC-based dynamic reference standard for the analysis of complex natural products using Jarrah honey as test sample.
description	In this paper, we describe a novel approach to the development of a reference standard for the quality control of complex natural products, which will assist in the assessment of their authenticity and purity. The proposed method provides a template for the selection of samples, which can be pooled to obtain a reference standard. A shortfall of such an approach is, however, that the pooled sample is static in nature and therefore unable to capture difference in processing conditions or natural variations triggered by geographical or climatic impacts over time. To address this, the paper also outlines the development of a dynamic reference standard, which allows for ongoing adjustments to future variations. The method employs High-Performance Thin Layer Chromatography (HPTLC) derived extract profiles processed by multivariate analysis. The development of the dynamic reference standard is illustrated using honey, a complex natural matrix, as an example.
format	article
author	Md Khairul Islam Tomislav Sostaric Lee Yong Lim Katherine Hammer Cornelia Locher
author_facet	Md Khairul Islam Tomislav Sostaric Lee Yong Lim Katherine Hammer Cornelia Locher
author_sort	Md Khairul Islam
title	Development of an HPTLC-based dynamic reference standard for the analysis of complex natural products using Jarrah honey as test sample.
title_short	Development of an HPTLC-based dynamic reference standard for the analysis of complex natural products using Jarrah honey as test sample.
title_full	Development of an HPTLC-based dynamic reference standard for the analysis of complex natural products using Jarrah honey as test sample.
title_fullStr	Development of an HPTLC-based dynamic reference standard for the analysis of complex natural products using Jarrah honey as test sample.
title_full_unstemmed	Development of an HPTLC-based dynamic reference standard for the analysis of complex natural products using Jarrah honey as test sample.
title_sort	development of an hptlc-based dynamic reference standard for the analysis of complex natural products using jarrah honey as test sample.
publisher	Public Library of Science (PLoS)
publishDate	2021
url	https://doaj.org/article/1c89e3d7f27d4cdba90832a588c78b00
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Development of an HPTLC-based dynamic reference standard for the analysis of complex natural products using Jarrah honey as test sample.

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