Tumour-vasculature development via endothelial-to-mesenchymal transition after radiotherapy controls CD44v6+ cancer cell and macrophage polarization

Radiotherapy is the main treatment for most cancer, but it is unclear if targeting tumour vasculature can enhance tumour radiosensitivity. Here, the authors show that tumour endothelial-mesenchymal transition after radiotherapy leads to proliferation of radioresistant CSCs and tumour associated macr...

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Autores principales:	Seo-Hyun Choi, A-Ram Kim, Jae-Kyung Nam, Jin-Mo Kim, Jee-Youn Kim, Haeng Ran Seo, Hae-June Lee, Jaeho Cho, Yoon-Jin Lee
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/1c8be8c45157487b80a64a318466f67b
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spelling	oai:doaj.org-article:1c8be8c45157487b80a64a318466f67b2021-12-02T15:34:40ZTumour-vasculature development via endothelial-to-mesenchymal transition after radiotherapy controls CD44v6+ cancer cell and macrophage polarization10.1038/s41467-018-07470-w2041-1723https://doaj.org/article/1c8be8c45157487b80a64a318466f67b2018-11-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-07470-whttps://doaj.org/toc/2041-1723Radiotherapy is the main treatment for most cancer, but it is unclear if targeting tumour vasculature can enhance tumour radiosensitivity. Here, the authors show that tumour endothelial-mesenchymal transition after radiotherapy leads to proliferation of radioresistant CSCs and tumour associated macrophages polarization.Seo-Hyun ChoiA-Ram KimJae-Kyung NamJin-Mo KimJee-Youn KimHaeng Ran SeoHae-June LeeJaeho ChoYoon-Jin LeeNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-18 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Seo-Hyun Choi A-Ram Kim Jae-Kyung Nam Jin-Mo Kim Jee-Youn Kim Haeng Ran Seo Hae-June Lee Jaeho Cho Yoon-Jin Lee Tumour-vasculature development via endothelial-to-mesenchymal transition after radiotherapy controls CD44v6+ cancer cell and macrophage polarization
description	Radiotherapy is the main treatment for most cancer, but it is unclear if targeting tumour vasculature can enhance tumour radiosensitivity. Here, the authors show that tumour endothelial-mesenchymal transition after radiotherapy leads to proliferation of radioresistant CSCs and tumour associated macrophages polarization.
format	article
author	Seo-Hyun Choi A-Ram Kim Jae-Kyung Nam Jin-Mo Kim Jee-Youn Kim Haeng Ran Seo Hae-June Lee Jaeho Cho Yoon-Jin Lee
author_facet	Seo-Hyun Choi A-Ram Kim Jae-Kyung Nam Jin-Mo Kim Jee-Youn Kim Haeng Ran Seo Hae-June Lee Jaeho Cho Yoon-Jin Lee
author_sort	Seo-Hyun Choi
title	Tumour-vasculature development via endothelial-to-mesenchymal transition after radiotherapy controls CD44v6+ cancer cell and macrophage polarization
title_short	Tumour-vasculature development via endothelial-to-mesenchymal transition after radiotherapy controls CD44v6+ cancer cell and macrophage polarization
title_full	Tumour-vasculature development via endothelial-to-mesenchymal transition after radiotherapy controls CD44v6+ cancer cell and macrophage polarization
title_fullStr	Tumour-vasculature development via endothelial-to-mesenchymal transition after radiotherapy controls CD44v6+ cancer cell and macrophage polarization
title_full_unstemmed	Tumour-vasculature development via endothelial-to-mesenchymal transition after radiotherapy controls CD44v6+ cancer cell and macrophage polarization
title_sort	tumour-vasculature development via endothelial-to-mesenchymal transition after radiotherapy controls cd44v6+ cancer cell and macrophage polarization
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/1c8be8c45157487b80a64a318466f67b
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Tumour-vasculature development via endothelial-to-mesenchymal transition after radiotherapy controls CD44v6+ cancer cell and macrophage polarization

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