Transplacental Antibody Transfer of Respiratory Syncytial Virus Specific IgG in Non-Human Primate Mother-Infant Pairs

One approach to protect new-borns against respiratory syncytial virus (RSV) is to vaccinate pregnant women in the last trimester of pregnancy. The boosting of circulating antibodies which can be transferred to the foetus would offer immune protection against the virus and ultimately the disease. Sin...

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Autores principales:	Michael P. Citron, Jessica McAnulty, Cheryl Callahan, Walter Knapp, Jane Fontenot, Pablo Morales, Jessica A. Flynn, Cameron M. Douglas, Amy S. Espeseth
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	maternal antibody animal model respiratory syncytial virus (RSV) non-human primate maternal immunization Medicine R
Acceso en línea:	https://doaj.org/article/1c8d05755ffa4400bec63cc9820e65cd
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spelling	oai:doaj.org-article:1c8d05755ffa4400bec63cc9820e65cd2021-11-25T18:38:18ZTransplacental Antibody Transfer of Respiratory Syncytial Virus Specific IgG in Non-Human Primate Mother-Infant Pairs10.3390/pathogens101114412076-0817https://doaj.org/article/1c8d05755ffa4400bec63cc9820e65cd2021-11-01T00:00:00Zhttps://www.mdpi.com/2076-0817/10/11/1441https://doaj.org/toc/2076-0817One approach to protect new-borns against respiratory syncytial virus (RSV) is to vaccinate pregnant women in the last trimester of pregnancy. The boosting of circulating antibodies which can be transferred to the foetus would offer immune protection against the virus and ultimately the disease. Since non-human primates (NHPs) have similar reproductive anatomy, physiology, and antibody architecture and kinetics to humans, we utilized this preclinical species to evaluate maternal immunization (MI) using an RSV F subunit vaccine. Three species of NHPs known for their ability to be infected with human RSV in experimental challenge studies were tested for RSV-specific antibodies. African green monkeys had the highest overall antibody levels of the old-world monkeys evaluated and they gave birth to offspring with anti-RSV titers that were proportional to their mother. These higher overall antibody levels are associated with greater durability found in their offspring. Immunization of RSV seropositive AGMs during late pregnancy boosts RSV titers, which consequentially results in significantly higher titers in the vaccinated new-borns compared to the new-borns of unvaccinated mothers. These findings, accomplished in small treatment group sizes, demonstrate a model that provides an efficient, resource sparing and translatable preclinical in vivo system for evaluating vaccine candidates for maternal immunization.Michael P. CitronJessica McAnultyCheryl CallahanWalter KnappJane FontenotPablo MoralesJessica A. FlynnCameron M. DouglasAmy S. EspesethMDPI AGarticlematernal antibodyanimal modelrespiratory syncytial virus (RSV)non-human primatematernal immunizationMedicineRENPathogens, Vol 10, Iss 1441, p 1441 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	maternal antibody animal model respiratory syncytial virus (RSV) non-human primate maternal immunization Medicine R
spellingShingle	maternal antibody animal model respiratory syncytial virus (RSV) non-human primate maternal immunization Medicine R Michael P. Citron Jessica McAnulty Cheryl Callahan Walter Knapp Jane Fontenot Pablo Morales Jessica A. Flynn Cameron M. Douglas Amy S. Espeseth Transplacental Antibody Transfer of Respiratory Syncytial Virus Specific IgG in Non-Human Primate Mother-Infant Pairs
description	One approach to protect new-borns against respiratory syncytial virus (RSV) is to vaccinate pregnant women in the last trimester of pregnancy. The boosting of circulating antibodies which can be transferred to the foetus would offer immune protection against the virus and ultimately the disease. Since non-human primates (NHPs) have similar reproductive anatomy, physiology, and antibody architecture and kinetics to humans, we utilized this preclinical species to evaluate maternal immunization (MI) using an RSV F subunit vaccine. Three species of NHPs known for their ability to be infected with human RSV in experimental challenge studies were tested for RSV-specific antibodies. African green monkeys had the highest overall antibody levels of the old-world monkeys evaluated and they gave birth to offspring with anti-RSV titers that were proportional to their mother. These higher overall antibody levels are associated with greater durability found in their offspring. Immunization of RSV seropositive AGMs during late pregnancy boosts RSV titers, which consequentially results in significantly higher titers in the vaccinated new-borns compared to the new-borns of unvaccinated mothers. These findings, accomplished in small treatment group sizes, demonstrate a model that provides an efficient, resource sparing and translatable preclinical in vivo system for evaluating vaccine candidates for maternal immunization.
format	article
author	Michael P. Citron Jessica McAnulty Cheryl Callahan Walter Knapp Jane Fontenot Pablo Morales Jessica A. Flynn Cameron M. Douglas Amy S. Espeseth
author_facet	Michael P. Citron Jessica McAnulty Cheryl Callahan Walter Knapp Jane Fontenot Pablo Morales Jessica A. Flynn Cameron M. Douglas Amy S. Espeseth
author_sort	Michael P. Citron
title	Transplacental Antibody Transfer of Respiratory Syncytial Virus Specific IgG in Non-Human Primate Mother-Infant Pairs
title_short	Transplacental Antibody Transfer of Respiratory Syncytial Virus Specific IgG in Non-Human Primate Mother-Infant Pairs
title_full	Transplacental Antibody Transfer of Respiratory Syncytial Virus Specific IgG in Non-Human Primate Mother-Infant Pairs
title_fullStr	Transplacental Antibody Transfer of Respiratory Syncytial Virus Specific IgG in Non-Human Primate Mother-Infant Pairs
title_full_unstemmed	Transplacental Antibody Transfer of Respiratory Syncytial Virus Specific IgG in Non-Human Primate Mother-Infant Pairs
title_sort	transplacental antibody transfer of respiratory syncytial virus specific igg in non-human primate mother-infant pairs
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/1c8d05755ffa4400bec63cc9820e65cd
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Transplacental Antibody Transfer of Respiratory Syncytial Virus Specific IgG in Non-Human Primate Mother-Infant Pairs

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