The microRNA analysis portal is a next-generation tool for exploring and analyzing miRNA-focused data in the literature

Abstract MicroRNAs constitute a class of noncoding small RNAs involved in the posttranscriptional regulation of many biological pathways. In recent years, microRNAs have also been associated with regulation across kingdoms, demonstrating that exogenous miRNAs can function in mammals in a fashion sim...

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Autores principales:	Stefano Pirrò, Ivana Matic, Vittorio Colizzi, Andrea Galgani
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/1c93731f0a78445eb05b72f17937609b
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spelling	oai:doaj.org-article:1c93731f0a78445eb05b72f17937609b2021-12-02T17:15:16ZThe microRNA analysis portal is a next-generation tool for exploring and analyzing miRNA-focused data in the literature10.1038/s41598-021-88617-62045-2322https://doaj.org/article/1c93731f0a78445eb05b72f17937609b2021-04-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-88617-6https://doaj.org/toc/2045-2322Abstract MicroRNAs constitute a class of noncoding small RNAs involved in the posttranscriptional regulation of many biological pathways. In recent years, microRNAs have also been associated with regulation across kingdoms, demonstrating that exogenous miRNAs can function in mammals in a fashion similar to mammalian miRNAs. The growing interest in microRNAs and the increasing amount of literature and molecular and biomedical data available make it difficult to identify records of interest and keep up to date with novel findings. For these reasons, we developed the microRNA Analysis Portal (MAP). MAP selects relevant miRNA-focused articles from PubMed, links biomedical and molecular data and applies bioinformatics modules. At the time of this writing, MAP represents the richest, most complete and integrated database focused on microRNAs. MAP also integrates an updated version of MirCompare (2.0), a computational platform used for selecting plant microRNAs on the basis of their ability to regulate mammalian genes. Both MAP and MirCompare functionalities were used to predict that microRNAs from Moringa oleifera have putative roles across kingdoms by regulating human genes coding for proteins of the immune system. Starting from a selection of 94 human microRNAs, MirCompare selected 6 Moringa oleifera functional homologs. The subsequent prediction of human targets and areas of functional enrichment highlighted the central involvement of these genes in regulating immune system processes, particularly the host-virus interaction processes in hepatitis B, cytomegalovirus, papillomavirus and coronavirus. This case of use showed how MAP can help to perform complex queries without any computational background. MAP is available at http://stablab.uniroma2.it/MAP .Stefano PirròIvana MaticVittorio ColizziAndrea GalganiNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-12 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Stefano Pirrò Ivana Matic Vittorio Colizzi Andrea Galgani The microRNA analysis portal is a next-generation tool for exploring and analyzing miRNA-focused data in the literature
description	Abstract MicroRNAs constitute a class of noncoding small RNAs involved in the posttranscriptional regulation of many biological pathways. In recent years, microRNAs have also been associated with regulation across kingdoms, demonstrating that exogenous miRNAs can function in mammals in a fashion similar to mammalian miRNAs. The growing interest in microRNAs and the increasing amount of literature and molecular and biomedical data available make it difficult to identify records of interest and keep up to date with novel findings. For these reasons, we developed the microRNA Analysis Portal (MAP). MAP selects relevant miRNA-focused articles from PubMed, links biomedical and molecular data and applies bioinformatics modules. At the time of this writing, MAP represents the richest, most complete and integrated database focused on microRNAs. MAP also integrates an updated version of MirCompare (2.0), a computational platform used for selecting plant microRNAs on the basis of their ability to regulate mammalian genes. Both MAP and MirCompare functionalities were used to predict that microRNAs from Moringa oleifera have putative roles across kingdoms by regulating human genes coding for proteins of the immune system. Starting from a selection of 94 human microRNAs, MirCompare selected 6 Moringa oleifera functional homologs. The subsequent prediction of human targets and areas of functional enrichment highlighted the central involvement of these genes in regulating immune system processes, particularly the host-virus interaction processes in hepatitis B, cytomegalovirus, papillomavirus and coronavirus. This case of use showed how MAP can help to perform complex queries without any computational background. MAP is available at http://stablab.uniroma2.it/MAP .
format	article
author	Stefano Pirrò Ivana Matic Vittorio Colizzi Andrea Galgani
author_facet	Stefano Pirrò Ivana Matic Vittorio Colizzi Andrea Galgani
author_sort	Stefano Pirrò
title	The microRNA analysis portal is a next-generation tool for exploring and analyzing miRNA-focused data in the literature
title_short	The microRNA analysis portal is a next-generation tool for exploring and analyzing miRNA-focused data in the literature
title_full	The microRNA analysis portal is a next-generation tool for exploring and analyzing miRNA-focused data in the literature
title_fullStr	The microRNA analysis portal is a next-generation tool for exploring and analyzing miRNA-focused data in the literature
title_full_unstemmed	The microRNA analysis portal is a next-generation tool for exploring and analyzing miRNA-focused data in the literature
title_sort	microrna analysis portal is a next-generation tool for exploring and analyzing mirna-focused data in the literature
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/1c93731f0a78445eb05b72f17937609b
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The microRNA analysis portal is a next-generation tool for exploring and analyzing miRNA-focused data in the literature

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