Generalized and social anxiety disorder interactomes show distinctive overlaps with striosome and matrix interactomes

Abstract Mechanisms underlying anxiety disorders remain elusive despite the discovery of several associated genes. We constructed the protein–protein interaction networks (interactomes) of six anxiety disorders and noted enrichment for striatal expression among common genes in the interactomes. Five...

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Autores principales:	Kalyani B. Karunakaran, Satoko Amemori, N. Balakrishnan, Madhavi K. Ganapathiraju, Ken-ichi Amemori
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/1c9405249a6748509f30b96b67acd96c
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spelling	oai:doaj.org-article:1c9405249a6748509f30b96b67acd96c2021-12-02T17:25:44ZGeneralized and social anxiety disorder interactomes show distinctive overlaps with striosome and matrix interactomes10.1038/s41598-021-97418-w2045-2322https://doaj.org/article/1c9405249a6748509f30b96b67acd96c2021-09-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-97418-whttps://doaj.org/toc/2045-2322Abstract Mechanisms underlying anxiety disorders remain elusive despite the discovery of several associated genes. We constructed the protein–protein interaction networks (interactomes) of six anxiety disorders and noted enrichment for striatal expression among common genes in the interactomes. Five of these interactomes shared distinctive overlaps with the interactomes of genes that were differentially expressed in two striatal compartments (striosomes and matrix). Generalized anxiety disorder and social anxiety disorder interactomes showed exclusive and statistically significant overlaps with the striosome and matrix interactomes, respectively. Systematic gene expression analysis with the anxiety disorder interactomes constrained to contain only those genes that were shared with striatal compartment interactomes revealed a bifurcation among the disorders, which was influenced by the anterior cingulate cortex, nucleus accumbens, amygdala and hippocampus, and the dopaminergic signaling pathway. Our results indicate that the functionally distinct striatal pathways constituted by the striosome and the matrix may influence the etiological differentiation of various anxiety disorders.Kalyani B. KarunakaranSatoko AmemoriN. BalakrishnanMadhavi K. GanapathirajuKen-ichi AmemoriNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-25 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Kalyani B. Karunakaran Satoko Amemori N. Balakrishnan Madhavi K. Ganapathiraju Ken-ichi Amemori Generalized and social anxiety disorder interactomes show distinctive overlaps with striosome and matrix interactomes
description	Abstract Mechanisms underlying anxiety disorders remain elusive despite the discovery of several associated genes. We constructed the protein–protein interaction networks (interactomes) of six anxiety disorders and noted enrichment for striatal expression among common genes in the interactomes. Five of these interactomes shared distinctive overlaps with the interactomes of genes that were differentially expressed in two striatal compartments (striosomes and matrix). Generalized anxiety disorder and social anxiety disorder interactomes showed exclusive and statistically significant overlaps with the striosome and matrix interactomes, respectively. Systematic gene expression analysis with the anxiety disorder interactomes constrained to contain only those genes that were shared with striatal compartment interactomes revealed a bifurcation among the disorders, which was influenced by the anterior cingulate cortex, nucleus accumbens, amygdala and hippocampus, and the dopaminergic signaling pathway. Our results indicate that the functionally distinct striatal pathways constituted by the striosome and the matrix may influence the etiological differentiation of various anxiety disorders.
format	article
author	Kalyani B. Karunakaran Satoko Amemori N. Balakrishnan Madhavi K. Ganapathiraju Ken-ichi Amemori
author_facet	Kalyani B. Karunakaran Satoko Amemori N. Balakrishnan Madhavi K. Ganapathiraju Ken-ichi Amemori
author_sort	Kalyani B. Karunakaran
title	Generalized and social anxiety disorder interactomes show distinctive overlaps with striosome and matrix interactomes
title_short	Generalized and social anxiety disorder interactomes show distinctive overlaps with striosome and matrix interactomes
title_full	Generalized and social anxiety disorder interactomes show distinctive overlaps with striosome and matrix interactomes
title_fullStr	Generalized and social anxiety disorder interactomes show distinctive overlaps with striosome and matrix interactomes
title_full_unstemmed	Generalized and social anxiety disorder interactomes show distinctive overlaps with striosome and matrix interactomes
title_sort	generalized and social anxiety disorder interactomes show distinctive overlaps with striosome and matrix interactomes
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/1c9405249a6748509f30b96b67acd96c
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_version_	1718380893214605312

Generalized and social anxiety disorder interactomes show distinctive overlaps with striosome and matrix interactomes

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