Pretreatment of Huaiqihuang extractum protects against cisplatin-induced nephrotoxicity

Abstract Cisplatin is a commonly used chemotherapeutic agent in the treatment of different types of malignant tumors, but nephrotoxicity limits its usage. Therefore, in this study, we aimed to determine the possible protective effect of Huaiqihuang (HQH) extractum, a kind of Chinese herbal complex t...

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Autores principales:	Yujiao Guo, Meng Wang, Jingyi Mou, Zhi Zhao, Juan Yang, Fengming Zhu, Guangchang Pei, Han Zhu, Yuxi Wang, Gang Xu, Rui Zeng, Ying Yao
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/1c973b9a290642eeb5dbb0ace56984d4
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spelling	oai:doaj.org-article:1c973b9a290642eeb5dbb0ace56984d42021-12-02T12:32:21ZPretreatment of Huaiqihuang extractum protects against cisplatin-induced nephrotoxicity10.1038/s41598-018-25610-62045-2322https://doaj.org/article/1c973b9a290642eeb5dbb0ace56984d42018-05-01T00:00:00Zhttps://doi.org/10.1038/s41598-018-25610-6https://doaj.org/toc/2045-2322Abstract Cisplatin is a commonly used chemotherapeutic agent in the treatment of different types of malignant tumors, but nephrotoxicity limits its usage. Therefore, in this study, we aimed to determine the possible protective effect of Huaiqihuang (HQH) extractum, a kind of Chinese herbal complex that consists of Trametes robiniophila Murr., Lycium barbarum and Polygonatum sibiricum, against nephrotoxicity induced by cisplatin in mice. We found that pretreatment with HQH significantly attenuated the cisplatin-induced increase in blood urea nitrogen (BUN), interstitial congestion, acute renal tubular injury and tubular cell apoptosis and necroptosis. It was further shown that HQH administration reduced cisplatin-induced release and nuclear-cytoplasmic translocation of HMGB1 and inactivated its downstream signaling molecules, TLR4 and NFκB, in renal tubular cells; as a result, HQH repressed cisplatin-induced TNF-α production. As dexamethasone (Dex) exerts renoprotective effects in severe Acute kidney injury (AKI), we compared it with HQH and found that HQH showed similar renoprotective effects to dexamethasone via similar mechanisms. Considering the potential side effects of corticosteroids, reducing the effectiveness of treatment and shortening survival in solid tumor patients, we suggest administration of HQH as a potential adjuvant for cisplatin therapy in solid tumor patients to preserve renal function.Yujiao GuoMeng WangJingyi MouZhi ZhaoJuan YangFengming ZhuGuangchang PeiHan ZhuYuxi WangGang XuRui ZengYing YaoNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 8, Iss 1, Pp 1-10 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Yujiao Guo Meng Wang Jingyi Mou Zhi Zhao Juan Yang Fengming Zhu Guangchang Pei Han Zhu Yuxi Wang Gang Xu Rui Zeng Ying Yao Pretreatment of Huaiqihuang extractum protects against cisplatin-induced nephrotoxicity
description	Abstract Cisplatin is a commonly used chemotherapeutic agent in the treatment of different types of malignant tumors, but nephrotoxicity limits its usage. Therefore, in this study, we aimed to determine the possible protective effect of Huaiqihuang (HQH) extractum, a kind of Chinese herbal complex that consists of Trametes robiniophila Murr., Lycium barbarum and Polygonatum sibiricum, against nephrotoxicity induced by cisplatin in mice. We found that pretreatment with HQH significantly attenuated the cisplatin-induced increase in blood urea nitrogen (BUN), interstitial congestion, acute renal tubular injury and tubular cell apoptosis and necroptosis. It was further shown that HQH administration reduced cisplatin-induced release and nuclear-cytoplasmic translocation of HMGB1 and inactivated its downstream signaling molecules, TLR4 and NFκB, in renal tubular cells; as a result, HQH repressed cisplatin-induced TNF-α production. As dexamethasone (Dex) exerts renoprotective effects in severe Acute kidney injury (AKI), we compared it with HQH and found that HQH showed similar renoprotective effects to dexamethasone via similar mechanisms. Considering the potential side effects of corticosteroids, reducing the effectiveness of treatment and shortening survival in solid tumor patients, we suggest administration of HQH as a potential adjuvant for cisplatin therapy in solid tumor patients to preserve renal function.
format	article
author	Yujiao Guo Meng Wang Jingyi Mou Zhi Zhao Juan Yang Fengming Zhu Guangchang Pei Han Zhu Yuxi Wang Gang Xu Rui Zeng Ying Yao
author_facet	Yujiao Guo Meng Wang Jingyi Mou Zhi Zhao Juan Yang Fengming Zhu Guangchang Pei Han Zhu Yuxi Wang Gang Xu Rui Zeng Ying Yao
author_sort	Yujiao Guo
title	Pretreatment of Huaiqihuang extractum protects against cisplatin-induced nephrotoxicity
title_short	Pretreatment of Huaiqihuang extractum protects against cisplatin-induced nephrotoxicity
title_full	Pretreatment of Huaiqihuang extractum protects against cisplatin-induced nephrotoxicity
title_fullStr	Pretreatment of Huaiqihuang extractum protects against cisplatin-induced nephrotoxicity
title_full_unstemmed	Pretreatment of Huaiqihuang extractum protects against cisplatin-induced nephrotoxicity
title_sort	pretreatment of huaiqihuang extractum protects against cisplatin-induced nephrotoxicity
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/1c973b9a290642eeb5dbb0ace56984d4
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Pretreatment of Huaiqihuang extractum protects against cisplatin-induced nephrotoxicity

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