Defects in TRPM7 channel function deregulate thrombopoiesis through altered cellular Mg2+ homeostasis and cytoskeletal architecture

Although Mg2+is vital for platelet activation and aggregation, its regulation in these cells is still largely unknown. Here, the authors show that TRPM7, a cation channel and a protein kinase, regulates thrombopoiesis and platelet size by affecting the cytoskeleton of these cells in mice and humans.

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Autores principales:	Simon Stritt, Paquita Nurden, Remi Favier, Marie Favier, Silvia Ferioli, Sanjeev K. Gotru, Judith M M. van Eeuwijk, Harald Schulze, Alan T. Nurden, Michele P. Lambert, Ernest Turro, Stephanie Burger-Stritt, Masayuki Matsushita, Lorenz Mittermeier, Paola Ballerini, Susanna Zierler, Michael A. Laffan, Vladimir Chubanov, Thomas Gudermann, Bernhard Nieswandt, Attila Braun
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2016
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/1c9bd1c1c30c4822a4e980e7631e57fa
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spelling	oai:doaj.org-article:1c9bd1c1c30c4822a4e980e7631e57fa2021-12-02T17:33:10ZDefects in TRPM7 channel function deregulate thrombopoiesis through altered cellular Mg2+ homeostasis and cytoskeletal architecture10.1038/ncomms110972041-1723https://doaj.org/article/1c9bd1c1c30c4822a4e980e7631e57fa2016-03-01T00:00:00Zhttps://doi.org/10.1038/ncomms11097https://doaj.org/toc/2041-1723Although Mg2+is vital for platelet activation and aggregation, its regulation in these cells is still largely unknown. Here, the authors show that TRPM7, a cation channel and a protein kinase, regulates thrombopoiesis and platelet size by affecting the cytoskeleton of these cells in mice and humans.Simon StrittPaquita NurdenRemi FavierMarie FavierSilvia FerioliSanjeev K. GotruJudith M M. van EeuwijkHarald SchulzeAlan T. NurdenMichele P. LambertErnest TurroStephanie Burger-StrittMasayuki MatsushitaLorenz MittermeierPaola BalleriniSusanna ZierlerMichael A. LaffanVladimir ChubanovThomas GudermannBernhard NieswandtAttila BraunNature PortfolioarticleScienceQENNature Communications, Vol 7, Iss 1, Pp 1-13 (2016)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Simon Stritt Paquita Nurden Remi Favier Marie Favier Silvia Ferioli Sanjeev K. Gotru Judith M M. van Eeuwijk Harald Schulze Alan T. Nurden Michele P. Lambert Ernest Turro Stephanie Burger-Stritt Masayuki Matsushita Lorenz Mittermeier Paola Ballerini Susanna Zierler Michael A. Laffan Vladimir Chubanov Thomas Gudermann Bernhard Nieswandt Attila Braun Defects in TRPM7 channel function deregulate thrombopoiesis through altered cellular Mg2+ homeostasis and cytoskeletal architecture
description	Although Mg2+is vital for platelet activation and aggregation, its regulation in these cells is still largely unknown. Here, the authors show that TRPM7, a cation channel and a protein kinase, regulates thrombopoiesis and platelet size by affecting the cytoskeleton of these cells in mice and humans.
format	article
author	Simon Stritt Paquita Nurden Remi Favier Marie Favier Silvia Ferioli Sanjeev K. Gotru Judith M M. van Eeuwijk Harald Schulze Alan T. Nurden Michele P. Lambert Ernest Turro Stephanie Burger-Stritt Masayuki Matsushita Lorenz Mittermeier Paola Ballerini Susanna Zierler Michael A. Laffan Vladimir Chubanov Thomas Gudermann Bernhard Nieswandt Attila Braun
author_facet	Simon Stritt Paquita Nurden Remi Favier Marie Favier Silvia Ferioli Sanjeev K. Gotru Judith M M. van Eeuwijk Harald Schulze Alan T. Nurden Michele P. Lambert Ernest Turro Stephanie Burger-Stritt Masayuki Matsushita Lorenz Mittermeier Paola Ballerini Susanna Zierler Michael A. Laffan Vladimir Chubanov Thomas Gudermann Bernhard Nieswandt Attila Braun
author_sort	Simon Stritt
title	Defects in TRPM7 channel function deregulate thrombopoiesis through altered cellular Mg2+ homeostasis and cytoskeletal architecture
title_short	Defects in TRPM7 channel function deregulate thrombopoiesis through altered cellular Mg2+ homeostasis and cytoskeletal architecture
title_full	Defects in TRPM7 channel function deregulate thrombopoiesis through altered cellular Mg2+ homeostasis and cytoskeletal architecture
title_fullStr	Defects in TRPM7 channel function deregulate thrombopoiesis through altered cellular Mg2+ homeostasis and cytoskeletal architecture
title_full_unstemmed	Defects in TRPM7 channel function deregulate thrombopoiesis through altered cellular Mg2+ homeostasis and cytoskeletal architecture
title_sort	defects in trpm7 channel function deregulate thrombopoiesis through altered cellular mg2+ homeostasis and cytoskeletal architecture
publisher	Nature Portfolio
publishDate	2016
url	https://doaj.org/article/1c9bd1c1c30c4822a4e980e7631e57fa
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Defects in TRPM7 channel function deregulate thrombopoiesis through altered cellular Mg2+ homeostasis and cytoskeletal architecture

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