Improving 10-deacetylbaccatin III-10-β-O-acetyltransferase catalytic fitness for Taxol production

Taxol is a widely used anticancer drug that is found in very low amounts in the bark of Taxus plants. Here, the authors improve the catalytic fitness of DBAT, an enzyme that catalyses the conversion of tree by products into taxol, enabling the design of anin vitrobiochemical systems for taxol produc...

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Autores principales: Bing-Juan Li, Hao Wang, Ting Gong, Jing-Jing Chen, Tian-Jiao Chen, Jin-Ling Yang, Ping Zhu
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2017
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Acceso en línea:https://doaj.org/article/1c9c40cbb888499f84b955c597c41d5a
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spelling oai:doaj.org-article:1c9c40cbb888499f84b955c597c41d5a2021-12-02T15:38:37ZImproving 10-deacetylbaccatin III-10-β-O-acetyltransferase catalytic fitness for Taxol production10.1038/ncomms155442041-1723https://doaj.org/article/1c9c40cbb888499f84b955c597c41d5a2017-05-01T00:00:00Zhttps://doi.org/10.1038/ncomms15544https://doaj.org/toc/2041-1723Taxol is a widely used anticancer drug that is found in very low amounts in the bark of Taxus plants. Here, the authors improve the catalytic fitness of DBAT, an enzyme that catalyses the conversion of tree by products into taxol, enabling the design of anin vitrobiochemical systems for taxol production.Bing-Juan LiHao WangTing GongJing-Jing ChenTian-Jiao ChenJin-Ling YangPing ZhuNature PortfolioarticleScienceQENNature Communications, Vol 8, Iss 1, Pp 1-14 (2017)
institution DOAJ
collection DOAJ
language EN
topic Science
Q
spellingShingle Science
Q
Bing-Juan Li
Hao Wang
Ting Gong
Jing-Jing Chen
Tian-Jiao Chen
Jin-Ling Yang
Ping Zhu
Improving 10-deacetylbaccatin III-10-β-O-acetyltransferase catalytic fitness for Taxol production
description Taxol is a widely used anticancer drug that is found in very low amounts in the bark of Taxus plants. Here, the authors improve the catalytic fitness of DBAT, an enzyme that catalyses the conversion of tree by products into taxol, enabling the design of anin vitrobiochemical systems for taxol production.
format article
author Bing-Juan Li
Hao Wang
Ting Gong
Jing-Jing Chen
Tian-Jiao Chen
Jin-Ling Yang
Ping Zhu
author_facet Bing-Juan Li
Hao Wang
Ting Gong
Jing-Jing Chen
Tian-Jiao Chen
Jin-Ling Yang
Ping Zhu
author_sort Bing-Juan Li
title Improving 10-deacetylbaccatin III-10-β-O-acetyltransferase catalytic fitness for Taxol production
title_short Improving 10-deacetylbaccatin III-10-β-O-acetyltransferase catalytic fitness for Taxol production
title_full Improving 10-deacetylbaccatin III-10-β-O-acetyltransferase catalytic fitness for Taxol production
title_fullStr Improving 10-deacetylbaccatin III-10-β-O-acetyltransferase catalytic fitness for Taxol production
title_full_unstemmed Improving 10-deacetylbaccatin III-10-β-O-acetyltransferase catalytic fitness for Taxol production
title_sort improving 10-deacetylbaccatin iii-10-β-o-acetyltransferase catalytic fitness for taxol production
publisher Nature Portfolio
publishDate 2017
url https://doaj.org/article/1c9c40cbb888499f84b955c597c41d5a
work_keys_str_mv AT bingjuanli improving10deacetylbaccatiniii10boacetyltransferasecatalyticfitnessfortaxolproduction
AT haowang improving10deacetylbaccatiniii10boacetyltransferasecatalyticfitnessfortaxolproduction
AT tinggong improving10deacetylbaccatiniii10boacetyltransferasecatalyticfitnessfortaxolproduction
AT jingjingchen improving10deacetylbaccatiniii10boacetyltransferasecatalyticfitnessfortaxolproduction
AT tianjiaochen improving10deacetylbaccatiniii10boacetyltransferasecatalyticfitnessfortaxolproduction
AT jinlingyang improving10deacetylbaccatiniii10boacetyltransferasecatalyticfitnessfortaxolproduction
AT pingzhu improving10deacetylbaccatiniii10boacetyltransferasecatalyticfitnessfortaxolproduction
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