Improving 10-deacetylbaccatin III-10-β-O-acetyltransferase catalytic fitness for Taxol production
Taxol is a widely used anticancer drug that is found in very low amounts in the bark of Taxus plants. Here, the authors improve the catalytic fitness of DBAT, an enzyme that catalyses the conversion of tree by products into taxol, enabling the design of anin vitrobiochemical systems for taxol produc...
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Nature Portfolio
2017
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oai:doaj.org-article:1c9c40cbb888499f84b955c597c41d5a2021-12-02T15:38:37ZImproving 10-deacetylbaccatin III-10-β-O-acetyltransferase catalytic fitness for Taxol production10.1038/ncomms155442041-1723https://doaj.org/article/1c9c40cbb888499f84b955c597c41d5a2017-05-01T00:00:00Zhttps://doi.org/10.1038/ncomms15544https://doaj.org/toc/2041-1723Taxol is a widely used anticancer drug that is found in very low amounts in the bark of Taxus plants. Here, the authors improve the catalytic fitness of DBAT, an enzyme that catalyses the conversion of tree by products into taxol, enabling the design of anin vitrobiochemical systems for taxol production.Bing-Juan LiHao WangTing GongJing-Jing ChenTian-Jiao ChenJin-Ling YangPing ZhuNature PortfolioarticleScienceQENNature Communications, Vol 8, Iss 1, Pp 1-14 (2017) |
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Science Q Bing-Juan Li Hao Wang Ting Gong Jing-Jing Chen Tian-Jiao Chen Jin-Ling Yang Ping Zhu Improving 10-deacetylbaccatin III-10-β-O-acetyltransferase catalytic fitness for Taxol production |
description |
Taxol is a widely used anticancer drug that is found in very low amounts in the bark of Taxus plants. Here, the authors improve the catalytic fitness of DBAT, an enzyme that catalyses the conversion of tree by products into taxol, enabling the design of anin vitrobiochemical systems for taxol production. |
format |
article |
author |
Bing-Juan Li Hao Wang Ting Gong Jing-Jing Chen Tian-Jiao Chen Jin-Ling Yang Ping Zhu |
author_facet |
Bing-Juan Li Hao Wang Ting Gong Jing-Jing Chen Tian-Jiao Chen Jin-Ling Yang Ping Zhu |
author_sort |
Bing-Juan Li |
title |
Improving 10-deacetylbaccatin III-10-β-O-acetyltransferase catalytic fitness for Taxol production |
title_short |
Improving 10-deacetylbaccatin III-10-β-O-acetyltransferase catalytic fitness for Taxol production |
title_full |
Improving 10-deacetylbaccatin III-10-β-O-acetyltransferase catalytic fitness for Taxol production |
title_fullStr |
Improving 10-deacetylbaccatin III-10-β-O-acetyltransferase catalytic fitness for Taxol production |
title_full_unstemmed |
Improving 10-deacetylbaccatin III-10-β-O-acetyltransferase catalytic fitness for Taxol production |
title_sort |
improving 10-deacetylbaccatin iii-10-β-o-acetyltransferase catalytic fitness for taxol production |
publisher |
Nature Portfolio |
publishDate |
2017 |
url |
https://doaj.org/article/1c9c40cbb888499f84b955c597c41d5a |
work_keys_str_mv |
AT bingjuanli improving10deacetylbaccatiniii10boacetyltransferasecatalyticfitnessfortaxolproduction AT haowang improving10deacetylbaccatiniii10boacetyltransferasecatalyticfitnessfortaxolproduction AT tinggong improving10deacetylbaccatiniii10boacetyltransferasecatalyticfitnessfortaxolproduction AT jingjingchen improving10deacetylbaccatiniii10boacetyltransferasecatalyticfitnessfortaxolproduction AT tianjiaochen improving10deacetylbaccatiniii10boacetyltransferasecatalyticfitnessfortaxolproduction AT jinlingyang improving10deacetylbaccatiniii10boacetyltransferasecatalyticfitnessfortaxolproduction AT pingzhu improving10deacetylbaccatiniii10boacetyltransferasecatalyticfitnessfortaxolproduction |
_version_ |
1718386097564680192 |