Clinicopathological significance of HSP70 expression in gastric cancer: a systematic review and meta-analysis

Abstract Background Heat shock protein 70 (HSP70) has been associated with the clinicopathological characteristics and prognosis of many cancers types, implying that it is a potential cancer biomarker. However, no consensus has been reached regarding its clinicopathological and prognostic significan...

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Autores principales:	Xiaolu Wang, Li Xie, Lijing Zhu
Formato:	article
Lenguaje:	EN
Publicado:	BMC 2021
Materias:	Heat shock protein 70 Biomarker Gastric cancer Clinicopathological significance Meta-analysis Diseases of the digestive system. Gastroenterology RC799-869
Acceso en línea:	https://doaj.org/article/1ca3e5dece8c4a48813bbf2f9199de16
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spelling	oai:doaj.org-article:1ca3e5dece8c4a48813bbf2f9199de162021-11-28T12:15:06ZClinicopathological significance of HSP70 expression in gastric cancer: a systematic review and meta-analysis10.1186/s12876-021-01990-41471-230Xhttps://doaj.org/article/1ca3e5dece8c4a48813bbf2f9199de162021-11-01T00:00:00Zhttps://doi.org/10.1186/s12876-021-01990-4https://doaj.org/toc/1471-230XAbstract Background Heat shock protein 70 (HSP70) has been associated with the clinicopathological characteristics and prognosis of many cancers types, implying that it is a potential cancer biomarker. However, no consensus has been reached regarding its clinicopathological and prognostic significance in patients with gastric cancer. To address this gap, we performed a systematic review and meta-analysis. Methods We searched PubMed, Embase, and the Cochrane Library for full-text literature according to the eligibility criteria. We used the odds ratio and hazard ratio as the suitable parameters to evaluate the clinicopathological and prognostic significance of HSP70. The statistical analysis was performed using STATA 15.0. Results After inclusion and exclusion of studies based on the eligibility criteria, data of 1,307 patients with gastric cancer from 9 studies were finally included. The pooled outcomes implied that HSP70 expression was significantly correlated with higher differentiation degrees, intestinal gastric cancer, and lymphovascular invasion but not with age, gender, depth of invasion, Helicobacter pylori infection, lymph node invasion, TNM stages, and metastasis. The pooled HR showed no significant correlation between HSP70 expression and overall survival of gastric cancer patients. Conclusions Our meta-analysis showed that HSP70 plays a complicated role in the development of gastric cancer. It may be directly engaged in tumour differentiation and distant invasion but cannot be considered a biomarker for predicting the prognosis of gastric cancer.Xiaolu WangLi XieLijing ZhuBMCarticleHeat shock protein 70BiomarkerGastric cancerClinicopathological significanceMeta-analysisDiseases of the digestive system. GastroenterologyRC799-869ENBMC Gastroenterology, Vol 21, Iss 1, Pp 1-12 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Heat shock protein 70 Biomarker Gastric cancer Clinicopathological significance Meta-analysis Diseases of the digestive system. Gastroenterology RC799-869
spellingShingle	Heat shock protein 70 Biomarker Gastric cancer Clinicopathological significance Meta-analysis Diseases of the digestive system. Gastroenterology RC799-869 Xiaolu Wang Li Xie Lijing Zhu Clinicopathological significance of HSP70 expression in gastric cancer: a systematic review and meta-analysis
description	Abstract Background Heat shock protein 70 (HSP70) has been associated with the clinicopathological characteristics and prognosis of many cancers types, implying that it is a potential cancer biomarker. However, no consensus has been reached regarding its clinicopathological and prognostic significance in patients with gastric cancer. To address this gap, we performed a systematic review and meta-analysis. Methods We searched PubMed, Embase, and the Cochrane Library for full-text literature according to the eligibility criteria. We used the odds ratio and hazard ratio as the suitable parameters to evaluate the clinicopathological and prognostic significance of HSP70. The statistical analysis was performed using STATA 15.0. Results After inclusion and exclusion of studies based on the eligibility criteria, data of 1,307 patients with gastric cancer from 9 studies were finally included. The pooled outcomes implied that HSP70 expression was significantly correlated with higher differentiation degrees, intestinal gastric cancer, and lymphovascular invasion but not with age, gender, depth of invasion, Helicobacter pylori infection, lymph node invasion, TNM stages, and metastasis. The pooled HR showed no significant correlation between HSP70 expression and overall survival of gastric cancer patients. Conclusions Our meta-analysis showed that HSP70 plays a complicated role in the development of gastric cancer. It may be directly engaged in tumour differentiation and distant invasion but cannot be considered a biomarker for predicting the prognosis of gastric cancer.
format	article
author	Xiaolu Wang Li Xie Lijing Zhu
author_facet	Xiaolu Wang Li Xie Lijing Zhu
author_sort	Xiaolu Wang
title	Clinicopathological significance of HSP70 expression in gastric cancer: a systematic review and meta-analysis
title_short	Clinicopathological significance of HSP70 expression in gastric cancer: a systematic review and meta-analysis
title_full	Clinicopathological significance of HSP70 expression in gastric cancer: a systematic review and meta-analysis
title_fullStr	Clinicopathological significance of HSP70 expression in gastric cancer: a systematic review and meta-analysis
title_full_unstemmed	Clinicopathological significance of HSP70 expression in gastric cancer: a systematic review and meta-analysis
title_sort	clinicopathological significance of hsp70 expression in gastric cancer: a systematic review and meta-analysis
publisher	BMC
publishDate	2021
url	https://doaj.org/article/1ca3e5dece8c4a48813bbf2f9199de16
work_keys_str_mv	AT xiaoluwang clinicopathologicalsignificanceofhsp70expressioningastriccancerasystematicreviewandmetaanalysis AT lixie clinicopathologicalsignificanceofhsp70expressioningastriccancerasystematicreviewandmetaanalysis AT lijingzhu clinicopathologicalsignificanceofhsp70expressioningastriccancerasystematicreviewandmetaanalysis
_version_	1718408061966614528

Clinicopathological significance of HSP70 expression in gastric cancer: a systematic review and meta-analysis

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