Cytokine expression patterns in hospitalized children with Bordetella pertussis, Rhinovirus or co-infection

Abstract Mechanisms of interaction between Bordetella pertussis and other viral agents are yet to be fully explored. We studied the inflammatory cytokine expression patterns among children with both viral-bacterial infections. Nasopharyngeal aspirate (NPA) samples were taken from children, aged <...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Elisabetta Pandolfi, Nadia Panera, Anna Alisi, Emanuela Carloni, Luisa Russo, Ilaria Campagna, Caterina Rizzo, Carlo Concato, Giulia Linardos, Livia Piccioni, Sally Jackson, Alberto Villani, Fabio Midulla, Alberto E. Tozzi
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/1ca5036c3ed54ac8ae854f23ce244af3
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:1ca5036c3ed54ac8ae854f23ce244af3
record_format	dspace
spelling	oai:doaj.org-article:1ca5036c3ed54ac8ae854f23ce244af32021-12-02T15:49:28ZCytokine expression patterns in hospitalized children with Bordetella pertussis, Rhinovirus or co-infection10.1038/s41598-021-89538-02045-2322https://doaj.org/article/1ca5036c3ed54ac8ae854f23ce244af32021-05-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-89538-0https://doaj.org/toc/2045-2322Abstract Mechanisms of interaction between Bordetella pertussis and other viral agents are yet to be fully explored. We studied the inflammatory cytokine expression patterns among children with both viral-bacterial infections. Nasopharyngeal aspirate (NPA) samples were taken from children, aged < 1 year, positive for Rhinovirus, Bordetella pertussis and for Rhinovirus and Bordetella pertussis. Forty cytokines were evaluated in NPA by using human cytokine protein arrays and a quantitative analysis was performed on significantly altered cytokines. Forty cytokines were evaluated in NPA by using human cytokine protein arrays and a quantitative analysis was performed on significantly altered cytokines. Our results show that co-infections display a different inflammatory pattern compared to single infections, suggesting that a chronic inflammation caused by one of the two pathogens could be the trigger for exacerbation in co-infections.Elisabetta PandolfiNadia PaneraAnna AlisiEmanuela CarloniLuisa RussoIlaria CampagnaCaterina RizzoCarlo ConcatoGiulia LinardosLivia PiccioniSally JacksonAlberto VillaniFabio MidullaAlberto E. TozziNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-11 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Elisabetta Pandolfi Nadia Panera Anna Alisi Emanuela Carloni Luisa Russo Ilaria Campagna Caterina Rizzo Carlo Concato Giulia Linardos Livia Piccioni Sally Jackson Alberto Villani Fabio Midulla Alberto E. Tozzi Cytokine expression patterns in hospitalized children with Bordetella pertussis, Rhinovirus or co-infection
description	Abstract Mechanisms of interaction between Bordetella pertussis and other viral agents are yet to be fully explored. We studied the inflammatory cytokine expression patterns among children with both viral-bacterial infections. Nasopharyngeal aspirate (NPA) samples were taken from children, aged < 1 year, positive for Rhinovirus, Bordetella pertussis and for Rhinovirus and Bordetella pertussis. Forty cytokines were evaluated in NPA by using human cytokine protein arrays and a quantitative analysis was performed on significantly altered cytokines. Forty cytokines were evaluated in NPA by using human cytokine protein arrays and a quantitative analysis was performed on significantly altered cytokines. Our results show that co-infections display a different inflammatory pattern compared to single infections, suggesting that a chronic inflammation caused by one of the two pathogens could be the trigger for exacerbation in co-infections.
format	article
author	Elisabetta Pandolfi Nadia Panera Anna Alisi Emanuela Carloni Luisa Russo Ilaria Campagna Caterina Rizzo Carlo Concato Giulia Linardos Livia Piccioni Sally Jackson Alberto Villani Fabio Midulla Alberto E. Tozzi
author_facet	Elisabetta Pandolfi Nadia Panera Anna Alisi Emanuela Carloni Luisa Russo Ilaria Campagna Caterina Rizzo Carlo Concato Giulia Linardos Livia Piccioni Sally Jackson Alberto Villani Fabio Midulla Alberto E. Tozzi
author_sort	Elisabetta Pandolfi
title	Cytokine expression patterns in hospitalized children with Bordetella pertussis, Rhinovirus or co-infection
title_short	Cytokine expression patterns in hospitalized children with Bordetella pertussis, Rhinovirus or co-infection
title_full	Cytokine expression patterns in hospitalized children with Bordetella pertussis, Rhinovirus or co-infection
title_fullStr	Cytokine expression patterns in hospitalized children with Bordetella pertussis, Rhinovirus or co-infection
title_full_unstemmed	Cytokine expression patterns in hospitalized children with Bordetella pertussis, Rhinovirus or co-infection
title_sort	cytokine expression patterns in hospitalized children with bordetella pertussis, rhinovirus or co-infection
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/1ca5036c3ed54ac8ae854f23ce244af3
work_keys_str_mv	AT elisabettapandolfi cytokineexpressionpatternsinhospitalizedchildrenwithbordetellapertussisrhinovirusorcoinfection AT nadiapanera cytokineexpressionpatternsinhospitalizedchildrenwithbordetellapertussisrhinovirusorcoinfection AT annaalisi cytokineexpressionpatternsinhospitalizedchildrenwithbordetellapertussisrhinovirusorcoinfection AT emanuelacarloni cytokineexpressionpatternsinhospitalizedchildrenwithbordetellapertussisrhinovirusorcoinfection AT luisarusso cytokineexpressionpatternsinhospitalizedchildrenwithbordetellapertussisrhinovirusorcoinfection AT ilariacampagna cytokineexpressionpatternsinhospitalizedchildrenwithbordetellapertussisrhinovirusorcoinfection AT caterinarizzo cytokineexpressionpatternsinhospitalizedchildrenwithbordetellapertussisrhinovirusorcoinfection AT carloconcato cytokineexpressionpatternsinhospitalizedchildrenwithbordetellapertussisrhinovirusorcoinfection AT giulialinardos cytokineexpressionpatternsinhospitalizedchildrenwithbordetellapertussisrhinovirusorcoinfection AT liviapiccioni cytokineexpressionpatternsinhospitalizedchildrenwithbordetellapertussisrhinovirusorcoinfection AT sallyjackson cytokineexpressionpatternsinhospitalizedchildrenwithbordetellapertussisrhinovirusorcoinfection AT albertovillani cytokineexpressionpatternsinhospitalizedchildrenwithbordetellapertussisrhinovirusorcoinfection AT fabiomidulla cytokineexpressionpatternsinhospitalizedchildrenwithbordetellapertussisrhinovirusorcoinfection AT albertoetozzi cytokineexpressionpatternsinhospitalizedchildrenwithbordetellapertussisrhinovirusorcoinfection
_version_	1718385676439781376

Cytokine expression patterns in hospitalized children with Bordetella pertussis, Rhinovirus or co-infection

Ejemplares similares