Role of cytokines in the pathogenesis of diffuse bacterial peritonitis

We analyzed present-day data in Russian and foreign literature on development of cytokine cascade in diffuse bacterial peritonitis having studied the role of cytokines in forming systemic inflammation response syndrome. It has been showed that cytokines primary regulate local protective response by...

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Autores principales:	E. E. Chepurnykh, І. A. Shurygina, E. S. Shaul'skaja, M. G. Shurygin
Formato:	article
Lenguaje:	RU
Publicado:	Scientific Сentre for Family Health and Human Reproduction Problems 2016
Materias:	diffuse bacterial peritonitis pathogenesis cytokines Science Q
Acceso en línea:	https://doaj.org/article/1ca5f9102a38419db3304b0b97a86583
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spelling	oai:doaj.org-article:1ca5f9102a38419db3304b0b97a865832021-11-23T06:14:35ZRole of cytokines in the pathogenesis of diffuse bacterial peritonitis2541-94202587-959610.12737/23029https://doaj.org/article/1ca5f9102a38419db3304b0b97a865832016-07-01T00:00:00Zhttps://www.actabiomedica.ru/jour/article/view/264https://doaj.org/toc/2541-9420https://doaj.org/toc/2587-9596We analyzed present-day data in Russian and foreign literature on development of cytokine cascade in diffuse bacterial peritonitis having studied the role of cytokines in forming systemic inflammation response syndrome. It has been showed that cytokines primary regulate local protective response by forming typical inflammatory reaction with its classic local manifestations and natural anti-microbial resistance mechanisms. The main stage in the development of diffuse bacterial peritonitis is a disbalance in the system of proinflammatory cytokines and anti-inflammatory mediators; and this disbalance defines the severity of extraabdominal complications and multisystem organ failure. In the article, the markers of inflammation severity are described assisting in evaluation of the course of inflammation process and postoperative survival rate. Due to changes in immune system of the patients, it is necessary to assess complexly their immune status including cytokine profile, which in this group of patients is of diagnostic and prognostic value and needs to be further studiedE. E. ChepurnykhІ. A. ShuryginaE. S. Shaul'skajaM. G. ShuryginScientific Сentre for Family Health and Human Reproduction Problemsarticlediffuse bacterial peritonitispathogenesiscytokinesScienceQRUActa Biomedica Scientifica, Vol 1, Iss 4, Pp 177-182 (2016)
institution	DOAJ
collection	DOAJ
language	RU
topic	diffuse bacterial peritonitis pathogenesis cytokines Science Q
spellingShingle	diffuse bacterial peritonitis pathogenesis cytokines Science Q E. E. Chepurnykh І. A. Shurygina E. S. Shaul'skaja M. G. Shurygin Role of cytokines in the pathogenesis of diffuse bacterial peritonitis
description	We analyzed present-day data in Russian and foreign literature on development of cytokine cascade in diffuse bacterial peritonitis having studied the role of cytokines in forming systemic inflammation response syndrome. It has been showed that cytokines primary regulate local protective response by forming typical inflammatory reaction with its classic local manifestations and natural anti-microbial resistance mechanisms. The main stage in the development of diffuse bacterial peritonitis is a disbalance in the system of proinflammatory cytokines and anti-inflammatory mediators; and this disbalance defines the severity of extraabdominal complications and multisystem organ failure. In the article, the markers of inflammation severity are described assisting in evaluation of the course of inflammation process and postoperative survival rate. Due to changes in immune system of the patients, it is necessary to assess complexly their immune status including cytokine profile, which in this group of patients is of diagnostic and prognostic value and needs to be further studied
format	article
author	E. E. Chepurnykh І. A. Shurygina E. S. Shaul'skaja M. G. Shurygin
author_facet	E. E. Chepurnykh І. A. Shurygina E. S. Shaul'skaja M. G. Shurygin
author_sort	E. E. Chepurnykh
title	Role of cytokines in the pathogenesis of diffuse bacterial peritonitis
title_short	Role of cytokines in the pathogenesis of diffuse bacterial peritonitis
title_full	Role of cytokines in the pathogenesis of diffuse bacterial peritonitis
title_fullStr	Role of cytokines in the pathogenesis of diffuse bacterial peritonitis
title_full_unstemmed	Role of cytokines in the pathogenesis of diffuse bacterial peritonitis
title_sort	role of cytokines in the pathogenesis of diffuse bacterial peritonitis
publisher	Scientific Сentre for Family Health and Human Reproduction Problems
publishDate	2016
url	https://doaj.org/article/1ca5f9102a38419db3304b0b97a86583
work_keys_str_mv	AT eechepurnykh roleofcytokinesinthepathogenesisofdiffusebacterialperitonitis AT íashurygina roleofcytokinesinthepathogenesisofdiffusebacterialperitonitis AT esshaulskaja roleofcytokinesinthepathogenesisofdiffusebacterialperitonitis AT mgshurygin roleofcytokinesinthepathogenesisofdiffusebacterialperitonitis
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Role of cytokines in the pathogenesis of diffuse bacterial peritonitis

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