Brain structural correlates of reward sensitivity and impulsivity in adolescents with normal and excess weight.

<h4>Introduction</h4>Neuroscience evidence suggests that adolescent obesity is linked to brain dysfunctions associated with enhanced reward and somatosensory processing and reduced impulse control during food processing. Comparatively less is known about the role of more stable brain str...

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Autores principales:	Laura Moreno-López, Carles Soriano-Mas, Elena Delgado-Rico, Jacqueline S Rio-Valle, Antonio Verdejo-García
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2012
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/1ca737f87db7408c838a9e25a3984ff1
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spelling	oai:doaj.org-article:1ca737f87db7408c838a9e25a3984ff12021-11-18T08:08:01ZBrain structural correlates of reward sensitivity and impulsivity in adolescents with normal and excess weight.1932-620310.1371/journal.pone.0049185https://doaj.org/article/1ca737f87db7408c838a9e25a3984ff12012-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/23185306/pdf/?tool=EBIhttps://doaj.org/toc/1932-6203<h4>Introduction</h4>Neuroscience evidence suggests that adolescent obesity is linked to brain dysfunctions associated with enhanced reward and somatosensory processing and reduced impulse control during food processing. Comparatively less is known about the role of more stable brain structural measures and their link to personality traits and neuropsychological factors on the presentation of adolescent obesity. Here we aimed to investigate regional brain anatomy in adolescents with excess weight vs. lean controls. We also aimed to contrast the associations between brain structure and personality and cognitive measures in both groups.<h4>Methods</h4>Fifty-two adolescents (16 with normal weight and 36 with excess weight) were scanned using magnetic resonance imaging and completed the Sensitivity to Punishment and Sensitivity to Reward Questionnaire (SPSRQ), the UPPS-P scale, and the Stroop task. Voxel-based morphometry (VBM) was used to assess possible between-group differences in regional gray matter (GM) and to measure the putative differences in the way reward and punishment sensitivity, impulsivity and inhibitory control relate to regional GM volumes, which were analyzed using both region of interest (ROI) and whole brain analyses. The ROIs included areas involved in reward/somatosensory processing (striatum, somatosensory cortices) and motivation/impulse control (hippocampus, prefrontal cortex).<h4>Results</h4>Excess weight adolescents showed increased GM volume in the right hippocampus. Voxel-wise volumes of the second somatosensory cortex (SII) were correlated with reward sensitivity and positive urgency in lean controls, but this association was missed in excess weight adolescents. Moreover, Stroop performance correlated with dorsolateral prefrontal cortex volumes in controls but not in excess weight adolescents.<h4>Conclusion</h4>Adolescents with excess weight have structural abnormalities in brain regions associated with somatosensory processing and motivation.Laura Moreno-LópezCarles Soriano-MasElena Delgado-RicoJacqueline S Rio-ValleAntonio Verdejo-GarcíaPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 7, Iss 11, p e49185 (2012)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Laura Moreno-López Carles Soriano-Mas Elena Delgado-Rico Jacqueline S Rio-Valle Antonio Verdejo-García Brain structural correlates of reward sensitivity and impulsivity in adolescents with normal and excess weight.
description	<h4>Introduction</h4>Neuroscience evidence suggests that adolescent obesity is linked to brain dysfunctions associated with enhanced reward and somatosensory processing and reduced impulse control during food processing. Comparatively less is known about the role of more stable brain structural measures and their link to personality traits and neuropsychological factors on the presentation of adolescent obesity. Here we aimed to investigate regional brain anatomy in adolescents with excess weight vs. lean controls. We also aimed to contrast the associations between brain structure and personality and cognitive measures in both groups.<h4>Methods</h4>Fifty-two adolescents (16 with normal weight and 36 with excess weight) were scanned using magnetic resonance imaging and completed the Sensitivity to Punishment and Sensitivity to Reward Questionnaire (SPSRQ), the UPPS-P scale, and the Stroop task. Voxel-based morphometry (VBM) was used to assess possible between-group differences in regional gray matter (GM) and to measure the putative differences in the way reward and punishment sensitivity, impulsivity and inhibitory control relate to regional GM volumes, which were analyzed using both region of interest (ROI) and whole brain analyses. The ROIs included areas involved in reward/somatosensory processing (striatum, somatosensory cortices) and motivation/impulse control (hippocampus, prefrontal cortex).<h4>Results</h4>Excess weight adolescents showed increased GM volume in the right hippocampus. Voxel-wise volumes of the second somatosensory cortex (SII) were correlated with reward sensitivity and positive urgency in lean controls, but this association was missed in excess weight adolescents. Moreover, Stroop performance correlated with dorsolateral prefrontal cortex volumes in controls but not in excess weight adolescents.<h4>Conclusion</h4>Adolescents with excess weight have structural abnormalities in brain regions associated with somatosensory processing and motivation.
format	article
author	Laura Moreno-López Carles Soriano-Mas Elena Delgado-Rico Jacqueline S Rio-Valle Antonio Verdejo-García
author_facet	Laura Moreno-López Carles Soriano-Mas Elena Delgado-Rico Jacqueline S Rio-Valle Antonio Verdejo-García
author_sort	Laura Moreno-López
title	Brain structural correlates of reward sensitivity and impulsivity in adolescents with normal and excess weight.
title_short	Brain structural correlates of reward sensitivity and impulsivity in adolescents with normal and excess weight.
title_full	Brain structural correlates of reward sensitivity and impulsivity in adolescents with normal and excess weight.
title_fullStr	Brain structural correlates of reward sensitivity and impulsivity in adolescents with normal and excess weight.
title_full_unstemmed	Brain structural correlates of reward sensitivity and impulsivity in adolescents with normal and excess weight.
title_sort	brain structural correlates of reward sensitivity and impulsivity in adolescents with normal and excess weight.
publisher	Public Library of Science (PLoS)
publishDate	2012
url	https://doaj.org/article/1ca737f87db7408c838a9e25a3984ff1
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_version_	1718422155654332416

Brain structural correlates of reward sensitivity and impulsivity in adolescents with normal and excess weight.

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