Distribution of estrogen receptor in the rabbit cervix during pregnancy with special reference to stromal elements: an immunohistochemical study

Abstract The estrogen plays a critical role during pregnancy through their receptors. Although the rabbit is one of the most important lab animal estrogen receptor alpha (ERA) localization on basic cells, newly discovered cells including telocyte and neuroendocrine cells, vascular compartments and i...

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Autores principales:	Fatma El-Zahraa A. Mustafa, Ruwaida Elhanbaly
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/1cabe35228b84f6583eef287c6b2bdd5
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spelling	oai:doaj.org-article:1cabe35228b84f6583eef287c6b2bdd52021-12-02T19:06:42ZDistribution of estrogen receptor in the rabbit cervix during pregnancy with special reference to stromal elements: an immunohistochemical study10.1038/s41598-020-70323-42045-2322https://doaj.org/article/1cabe35228b84f6583eef287c6b2bdd52020-08-01T00:00:00Zhttps://doi.org/10.1038/s41598-020-70323-4https://doaj.org/toc/2045-2322Abstract The estrogen plays a critical role during pregnancy through their receptors. Although the rabbit is one of the most important lab animal estrogen receptor alpha (ERA) localization on basic cells, newly discovered cells including telocyte and neuroendocrine cells, vascular compartments and interstitium during pregnancy not been described. At 0 day pregnancy, the most prominent immunoreactivity was moderate to ERA and observed on the ciliated cells, secretory cells, blood plasma, and interstitium. The smooth muscles and the endothelial cells showed mild immunoreactivity to ERA. Lymphocytes only exhibited strong immunoreactivity to ERA. At 7 days pregnancy moderate immunoreactivity to ERA observed on ciliated cells, secretory cells, smooth muscles, interstitium, and lymphocytes. Strong immunoreactivity to ERA detected on endothelial cells and blood plasma. At 14 days of pregnancy, the most prominent immunoreactivity was strong and detected on ciliated cells, smooth muscles, lymphocytes, and interstitium. Moderate immunoreactivity detected on endothelial cells and blood plasma. Secretory cells only exhibited mild immunoreactivity to ERA. At 21 days of pregnancy, the immunoreactivity to ERA ranged between mild on ciliated cells, smooth muscles, blood plasma and interstitium and negative on secretory cells, endothelial cells and lymphocytes. Our results indicated that the frequency and intensity of ERA immunostaining in the rabbit cervix varied on different structural compartments of the cervix during different pregnancy stages.Fatma El-Zahraa A. MustafaRuwaida ElhanbalyNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 10, Iss 1, Pp 1-12 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Fatma El-Zahraa A. Mustafa Ruwaida Elhanbaly Distribution of estrogen receptor in the rabbit cervix during pregnancy with special reference to stromal elements: an immunohistochemical study
description	Abstract The estrogen plays a critical role during pregnancy through their receptors. Although the rabbit is one of the most important lab animal estrogen receptor alpha (ERA) localization on basic cells, newly discovered cells including telocyte and neuroendocrine cells, vascular compartments and interstitium during pregnancy not been described. At 0 day pregnancy, the most prominent immunoreactivity was moderate to ERA and observed on the ciliated cells, secretory cells, blood plasma, and interstitium. The smooth muscles and the endothelial cells showed mild immunoreactivity to ERA. Lymphocytes only exhibited strong immunoreactivity to ERA. At 7 days pregnancy moderate immunoreactivity to ERA observed on ciliated cells, secretory cells, smooth muscles, interstitium, and lymphocytes. Strong immunoreactivity to ERA detected on endothelial cells and blood plasma. At 14 days of pregnancy, the most prominent immunoreactivity was strong and detected on ciliated cells, smooth muscles, lymphocytes, and interstitium. Moderate immunoreactivity detected on endothelial cells and blood plasma. Secretory cells only exhibited mild immunoreactivity to ERA. At 21 days of pregnancy, the immunoreactivity to ERA ranged between mild on ciliated cells, smooth muscles, blood plasma and interstitium and negative on secretory cells, endothelial cells and lymphocytes. Our results indicated that the frequency and intensity of ERA immunostaining in the rabbit cervix varied on different structural compartments of the cervix during different pregnancy stages.
format	article
author	Fatma El-Zahraa A. Mustafa Ruwaida Elhanbaly
author_facet	Fatma El-Zahraa A. Mustafa Ruwaida Elhanbaly
author_sort	Fatma El-Zahraa A. Mustafa
title	Distribution of estrogen receptor in the rabbit cervix during pregnancy with special reference to stromal elements: an immunohistochemical study
title_short	Distribution of estrogen receptor in the rabbit cervix during pregnancy with special reference to stromal elements: an immunohistochemical study
title_full	Distribution of estrogen receptor in the rabbit cervix during pregnancy with special reference to stromal elements: an immunohistochemical study
title_fullStr	Distribution of estrogen receptor in the rabbit cervix during pregnancy with special reference to stromal elements: an immunohistochemical study
title_full_unstemmed	Distribution of estrogen receptor in the rabbit cervix during pregnancy with special reference to stromal elements: an immunohistochemical study
title_sort	distribution of estrogen receptor in the rabbit cervix during pregnancy with special reference to stromal elements: an immunohistochemical study
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/1cabe35228b84f6583eef287c6b2bdd5
work_keys_str_mv	AT fatmaelzahraaamustafa distributionofestrogenreceptorintherabbitcervixduringpregnancywithspecialreferencetostromalelementsanimmunohistochemicalstudy AT ruwaidaelhanbaly distributionofestrogenreceptorintherabbitcervixduringpregnancywithspecialreferencetostromalelementsanimmunohistochemicalstudy
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Distribution of estrogen receptor in the rabbit cervix during pregnancy with special reference to stromal elements: an immunohistochemical study

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