Pyroptosis-Mediated Molecular Subtypes and Tumor Microenvironment Infiltration Characterization in Colon Cancer

The role of pyroptosis, which is also a kind of cell-intrinsic death mechanism, in tumorigenesis and cancer progression has been revolutionized. However, the expression of pyroptosis-related genes (PYGs) in colon cancer (CC) and their prognostic value remain unclear. In this study, we comprehensivel...

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Autores principales:	Jiawei Rao, Wen Li, Chuangqi Chen
Formato:	article
Lenguaje:	EN
Publicado:	Frontiers Media S.A. 2021
Materias:	pyroptosis colon cancer tumor microenvironment prognosis therapy Biology (General) QH301-705.5
Acceso en línea:	https://doaj.org/article/1cafe576928e421a94bb5c9953e8e739
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spelling	oai:doaj.org-article:1cafe576928e421a94bb5c9953e8e7392021-11-10T06:44:28ZPyroptosis-Mediated Molecular Subtypes and Tumor Microenvironment Infiltration Characterization in Colon Cancer2296-634X10.3389/fcell.2021.766503https://doaj.org/article/1cafe576928e421a94bb5c9953e8e7392021-11-01T00:00:00Zhttps://www.frontiersin.org/articles/10.3389/fcell.2021.766503/fullhttps://doaj.org/toc/2296-634XThe role of pyroptosis, which is also a kind of cell-intrinsic death mechanism, in tumorigenesis and cancer progression has been revolutionized. However, the expression of pyroptosis-related genes (PYGs) in colon cancer (CC) and their prognostic value remain unclear. In this study, we comprehensively identified two PYG-mediated molecular subtypes with a distinct tumor microenvironment (TME) in 1,415 CC samples, which were based on 10 PYGs. The six-gene signature (pyroptosis score, PY-score) was constructed to quantify the molecular patterns of individual tumors using a least absolute shrinkage and selection operator (LASSO)–Cox regression model through the differentially expressed genes between the two molecular subtypes. Significant infiltration of activated immune cells (such as M1 macrophages and cytotoxic T cells) was observed in the low PY-score group, while naive and suppressive immune cells (such as naive CD8+ T cells and M2 macrophages) dominated in the high PY-score group. CC patients in the low PY-score group showed not only significant survival advantage but also sensitivity to immune checkpoint inhibitor treatment, anti-epidermal growth factor receptor (EGFR) therapy, and chemotherapy. Overall, this work revealed that the PYGs played a vital role in the formation of heterogeneity in the TME. The analysis of the PYG-mediated molecular patterns helps in understanding the characterization of TME infiltration and provides insights into more effective therapeutic strategies.Jiawei RaoJiawei RaoWen LiChuangqi ChenFrontiers Media S.A.articlepyroptosiscolon cancertumor microenvironmentprognosistherapyBiology (General)QH301-705.5ENFrontiers in Cell and Developmental Biology, Vol 9 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	pyroptosis colon cancer tumor microenvironment prognosis therapy Biology (General) QH301-705.5
spellingShingle	pyroptosis colon cancer tumor microenvironment prognosis therapy Biology (General) QH301-705.5 Jiawei Rao Jiawei Rao Wen Li Chuangqi Chen Pyroptosis-Mediated Molecular Subtypes and Tumor Microenvironment Infiltration Characterization in Colon Cancer
description	The role of pyroptosis, which is also a kind of cell-intrinsic death mechanism, in tumorigenesis and cancer progression has been revolutionized. However, the expression of pyroptosis-related genes (PYGs) in colon cancer (CC) and their prognostic value remain unclear. In this study, we comprehensively identified two PYG-mediated molecular subtypes with a distinct tumor microenvironment (TME) in 1,415 CC samples, which were based on 10 PYGs. The six-gene signature (pyroptosis score, PY-score) was constructed to quantify the molecular patterns of individual tumors using a least absolute shrinkage and selection operator (LASSO)–Cox regression model through the differentially expressed genes between the two molecular subtypes. Significant infiltration of activated immune cells (such as M1 macrophages and cytotoxic T cells) was observed in the low PY-score group, while naive and suppressive immune cells (such as naive CD8+ T cells and M2 macrophages) dominated in the high PY-score group. CC patients in the low PY-score group showed not only significant survival advantage but also sensitivity to immune checkpoint inhibitor treatment, anti-epidermal growth factor receptor (EGFR) therapy, and chemotherapy. Overall, this work revealed that the PYGs played a vital role in the formation of heterogeneity in the TME. The analysis of the PYG-mediated molecular patterns helps in understanding the characterization of TME infiltration and provides insights into more effective therapeutic strategies.
format	article
author	Jiawei Rao Jiawei Rao Wen Li Chuangqi Chen
author_facet	Jiawei Rao Jiawei Rao Wen Li Chuangqi Chen
author_sort	Jiawei Rao
title	Pyroptosis-Mediated Molecular Subtypes and Tumor Microenvironment Infiltration Characterization in Colon Cancer
title_short	Pyroptosis-Mediated Molecular Subtypes and Tumor Microenvironment Infiltration Characterization in Colon Cancer
title_full	Pyroptosis-Mediated Molecular Subtypes and Tumor Microenvironment Infiltration Characterization in Colon Cancer
title_fullStr	Pyroptosis-Mediated Molecular Subtypes and Tumor Microenvironment Infiltration Characterization in Colon Cancer
title_full_unstemmed	Pyroptosis-Mediated Molecular Subtypes and Tumor Microenvironment Infiltration Characterization in Colon Cancer
title_sort	pyroptosis-mediated molecular subtypes and tumor microenvironment infiltration characterization in colon cancer
publisher	Frontiers Media S.A.
publishDate	2021
url	https://doaj.org/article/1cafe576928e421a94bb5c9953e8e739
work_keys_str_mv	AT jiaweirao pyroptosismediatedmolecularsubtypesandtumormicroenvironmentinfiltrationcharacterizationincoloncancer AT jiaweirao pyroptosismediatedmolecularsubtypesandtumormicroenvironmentinfiltrationcharacterizationincoloncancer AT wenli pyroptosismediatedmolecularsubtypesandtumormicroenvironmentinfiltrationcharacterizationincoloncancer AT chuangqichen pyroptosismediatedmolecularsubtypesandtumormicroenvironmentinfiltrationcharacterizationincoloncancer
_version_	1718440446700552192

Pyroptosis-Mediated Molecular Subtypes and Tumor Microenvironment Infiltration Characterization in Colon Cancer

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