Local/Topical Antibiotics for Peri-Implantitis Treatment: A Systematic Review

Most studies indicate that the mechanical removal of the bacterial biofilm from the implant surface is the central goal of peri-implantitis therapy. However, controversial results in the treatment of peri-implantitis have led to the consideration of additional strategies that include surgical approa...

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Autores principales:	Pier Carmine Passarelli, Andrea Netti, Michele Antonio Lopez, Eleonora Favetti Giaquinto, Giuseppe De Rosa, Gianmarco Aureli, Alina Bodnarenko, Piero Papi, Anna Starzyńska, Giorgio Pompa, Antonio D’Addona
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	chemical adjuvants peri-implantitis peri-implant mucositis local antibiotics minocycline clinical practice guidelines Therapeutics. Pharmacology RM1-950
Acceso en línea:	https://doaj.org/article/1cb385598cb74286b3131f057c083d38
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spelling	oai:doaj.org-article:1cb385598cb74286b3131f057c083d382021-11-25T16:22:18ZLocal/Topical Antibiotics for Peri-Implantitis Treatment: A Systematic Review10.3390/antibiotics101112982079-6382https://doaj.org/article/1cb385598cb74286b3131f057c083d382021-10-01T00:00:00Zhttps://www.mdpi.com/2079-6382/10/11/1298https://doaj.org/toc/2079-6382Most studies indicate that the mechanical removal of the bacterial biofilm from the implant surface is the central goal of peri-implantitis therapy. However, controversial results in the treatment of peri-implantitis have led to the consideration of additional strategies that include surgical approaches and chemical adjuvants. Local/topical antibiotics, such as minocycline, azithromycin, tetracycline, amoxicillin, doxycycline, and metronidazole, may improve the efficacy of the definitive treatment of the disease, but the lack of conclusive findings prevents their use in clinical practice. This systematic review aimed to evaluate the effect of local/topical antibiotics for peri-implantitis treatment. Randomised controlled studies (RCT) on patients with peri-implantitis and comparing the efficacy of local/topical antibiotics vs. placebo or mechanical debridement were included. A systematic search strategy was carried out using three registered databases (PubMed, Web of Science, and Scopus). RoB2 was used to assess risk of bias. Five RCTs were identified (<i>n</i> = 250 patients and 333 implants). Contrast results emerged among the included studies, and a high heterogeneity level was observed. Risk of bias revealed some concerns for three studies out of five, while one study was judged at high risk. Only one study analysed the limitations of its findings. Overall, local antibiotic use can be considered a valid approach in the treatment of peri-implantitis. Therefore, future long-term clinical trials with standardised protocols and antibiotics with similar biological activity profiles should be tested to achieve a valid and definitive conclusion.Pier Carmine PassarelliAndrea NettiMichele Antonio LopezEleonora Favetti GiaquintoGiuseppe De RosaGianmarco AureliAlina BodnarenkoPiero PapiAnna StarzyńskaGiorgio PompaAntonio D’AddonaMDPI AGarticlechemical adjuvantsperi-implantitisperi-implant mucositislocal antibioticsminocyclineclinical practice guidelinesTherapeutics. PharmacologyRM1-950ENAntibiotics, Vol 10, Iss 1298, p 1298 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	chemical adjuvants peri-implantitis peri-implant mucositis local antibiotics minocycline clinical practice guidelines Therapeutics. Pharmacology RM1-950
spellingShingle	chemical adjuvants peri-implantitis peri-implant mucositis local antibiotics minocycline clinical practice guidelines Therapeutics. Pharmacology RM1-950 Pier Carmine Passarelli Andrea Netti Michele Antonio Lopez Eleonora Favetti Giaquinto Giuseppe De Rosa Gianmarco Aureli Alina Bodnarenko Piero Papi Anna Starzyńska Giorgio Pompa Antonio D’Addona Local/Topical Antibiotics for Peri-Implantitis Treatment: A Systematic Review
description	Most studies indicate that the mechanical removal of the bacterial biofilm from the implant surface is the central goal of peri-implantitis therapy. However, controversial results in the treatment of peri-implantitis have led to the consideration of additional strategies that include surgical approaches and chemical adjuvants. Local/topical antibiotics, such as minocycline, azithromycin, tetracycline, amoxicillin, doxycycline, and metronidazole, may improve the efficacy of the definitive treatment of the disease, but the lack of conclusive findings prevents their use in clinical practice. This systematic review aimed to evaluate the effect of local/topical antibiotics for peri-implantitis treatment. Randomised controlled studies (RCT) on patients with peri-implantitis and comparing the efficacy of local/topical antibiotics vs. placebo or mechanical debridement were included. A systematic search strategy was carried out using three registered databases (PubMed, Web of Science, and Scopus). RoB2 was used to assess risk of bias. Five RCTs were identified (<i>n</i> = 250 patients and 333 implants). Contrast results emerged among the included studies, and a high heterogeneity level was observed. Risk of bias revealed some concerns for three studies out of five, while one study was judged at high risk. Only one study analysed the limitations of its findings. Overall, local antibiotic use can be considered a valid approach in the treatment of peri-implantitis. Therefore, future long-term clinical trials with standardised protocols and antibiotics with similar biological activity profiles should be tested to achieve a valid and definitive conclusion.
format	article
author	Pier Carmine Passarelli Andrea Netti Michele Antonio Lopez Eleonora Favetti Giaquinto Giuseppe De Rosa Gianmarco Aureli Alina Bodnarenko Piero Papi Anna Starzyńska Giorgio Pompa Antonio D’Addona
author_facet	Pier Carmine Passarelli Andrea Netti Michele Antonio Lopez Eleonora Favetti Giaquinto Giuseppe De Rosa Gianmarco Aureli Alina Bodnarenko Piero Papi Anna Starzyńska Giorgio Pompa Antonio D’Addona
author_sort	Pier Carmine Passarelli
title	Local/Topical Antibiotics for Peri-Implantitis Treatment: A Systematic Review
title_short	Local/Topical Antibiotics for Peri-Implantitis Treatment: A Systematic Review
title_full	Local/Topical Antibiotics for Peri-Implantitis Treatment: A Systematic Review
title_fullStr	Local/Topical Antibiotics for Peri-Implantitis Treatment: A Systematic Review
title_full_unstemmed	Local/Topical Antibiotics for Peri-Implantitis Treatment: A Systematic Review
title_sort	local/topical antibiotics for peri-implantitis treatment: a systematic review
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/1cb385598cb74286b3131f057c083d38
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Local/Topical Antibiotics for Peri-Implantitis Treatment: A Systematic Review

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