HISTOPATHOLOGICAL CHANGES IN PLACENTAL TISSUE OF COVID–19 PREGNANT WOMEN DELIVERED AT PAK EMIRATE MILITARY HOSPITAL, RAWALPINDI

Objective: To document the histological changes in the placentas of COVID-19 pregnant women. Study Design: Case series. Place and Duration of Study: Gynaecology department of Pak Emirate Military Hospital, from Mar 2020 to Jul 2020. Methodology: Nine placentas of COVID-19 positive women wer...

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Autores principales:	Samina Waqar, Aiza Saadia, Zainab Abbas, Farhan Akhtar, Abeera Choudry, Jehan Ara Rafiq Baig
Formato:	article
Lenguaje:	EN
Publicado:	Army Medical College Rawalpindi 2020
Materias:	covid-19 placenta thrombosis Medicine R Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/1cb5ecc0a4eb47bc8c94e7ca70b47729
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spelling	oai:doaj.org-article:1cb5ecc0a4eb47bc8c94e7ca70b477292021-12-02T17:41:21ZHISTOPATHOLOGICAL CHANGES IN PLACENTAL TISSUE OF COVID–19 PREGNANT WOMEN DELIVERED AT PAK EMIRATE MILITARY HOSPITAL, RAWALPINDI0030-96482411-8842https://doaj.org/article/1cb5ecc0a4eb47bc8c94e7ca70b477292020-09-01T00:00:00Zhttps://pafmj.org/index.php/PAFMJ/article/view/5223https://doaj.org/toc/0030-9648https://doaj.org/toc/2411-8842Objective: To document the histological changes in the placentas of COVID-19 pregnant women. Study Design: Case series. Place and Duration of Study: Gynaecology department of Pak Emirate Military Hospital, from Mar 2020 to Jul 2020. Methodology: Nine placentas of COVID-19 positive women were included in the study. Placentas of patients with other co-morbid conditions (diabetes, hypertension, pre eclampsia, eclampsia or any infection) were excluded from the study. Results: The most common lesions were avascular, hyalinised, infarcted villi, perivillous and intervillous fibrin deposition, thrombosis of umbilical cord artery and congestion. Thrombosis of chorionic vessels were seen in 5 cases (Mean 0.55, 55.55%). Intervillous thrombosis was seen in 5 cases (Mean 0.55, 55.55%) and chorangiosis was seen in three cases (Mean 0.33, 33.3%). One case of acute chorioamniotis and intervillositis (Mean 0.11, 11.11%) with neutrophilic infiltrate was present, which was confirmed by applying immunohistochemistry with Myeloperoxidase (MPO) stain. Conclusion: In this study, histological changes are seen in nine placentas of COVID-19 affected women, which showed evidence of thrombosis and associated changes. Although new-borns did not show any abnormality, significant histological changes observed, warrant the risk to fetuses like still birth and miscarriages. Further studies with large sample size could possibly make these consequences more clear. Also introduction of treatment like anti thrombotic therapy may be considered to overcome placental changes to avoid their harmful effects.Samina WaqarAiza SaadiaZainab AbbasFarhan AkhtarAbeera ChoudryJehan Ara Rafiq BaigArmy Medical College Rawalpindiarticlecovid-19placentathrombosisMedicineRMedicine (General)R5-920ENPakistan Armed Forces Medical Journal, Vol 70, Iss 2, Pp 434-438 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	covid-19 placenta thrombosis Medicine R Medicine (General) R5-920
spellingShingle	covid-19 placenta thrombosis Medicine R Medicine (General) R5-920 Samina Waqar Aiza Saadia Zainab Abbas Farhan Akhtar Abeera Choudry Jehan Ara Rafiq Baig HISTOPATHOLOGICAL CHANGES IN PLACENTAL TISSUE OF COVID–19 PREGNANT WOMEN DELIVERED AT PAK EMIRATE MILITARY HOSPITAL, RAWALPINDI
description	Objective: To document the histological changes in the placentas of COVID-19 pregnant women. Study Design: Case series. Place and Duration of Study: Gynaecology department of Pak Emirate Military Hospital, from Mar 2020 to Jul 2020. Methodology: Nine placentas of COVID-19 positive women were included in the study. Placentas of patients with other co-morbid conditions (diabetes, hypertension, pre eclampsia, eclampsia or any infection) were excluded from the study. Results: The most common lesions were avascular, hyalinised, infarcted villi, perivillous and intervillous fibrin deposition, thrombosis of umbilical cord artery and congestion. Thrombosis of chorionic vessels were seen in 5 cases (Mean 0.55, 55.55%). Intervillous thrombosis was seen in 5 cases (Mean 0.55, 55.55%) and chorangiosis was seen in three cases (Mean 0.33, 33.3%). One case of acute chorioamniotis and intervillositis (Mean 0.11, 11.11%) with neutrophilic infiltrate was present, which was confirmed by applying immunohistochemistry with Myeloperoxidase (MPO) stain. Conclusion: In this study, histological changes are seen in nine placentas of COVID-19 affected women, which showed evidence of thrombosis and associated changes. Although new-borns did not show any abnormality, significant histological changes observed, warrant the risk to fetuses like still birth and miscarriages. Further studies with large sample size could possibly make these consequences more clear. Also introduction of treatment like anti thrombotic therapy may be considered to overcome placental changes to avoid their harmful effects.
format	article
author	Samina Waqar Aiza Saadia Zainab Abbas Farhan Akhtar Abeera Choudry Jehan Ara Rafiq Baig
author_facet	Samina Waqar Aiza Saadia Zainab Abbas Farhan Akhtar Abeera Choudry Jehan Ara Rafiq Baig
author_sort	Samina Waqar
title	HISTOPATHOLOGICAL CHANGES IN PLACENTAL TISSUE OF COVID–19 PREGNANT WOMEN DELIVERED AT PAK EMIRATE MILITARY HOSPITAL, RAWALPINDI
title_short	HISTOPATHOLOGICAL CHANGES IN PLACENTAL TISSUE OF COVID–19 PREGNANT WOMEN DELIVERED AT PAK EMIRATE MILITARY HOSPITAL, RAWALPINDI
title_full	HISTOPATHOLOGICAL CHANGES IN PLACENTAL TISSUE OF COVID–19 PREGNANT WOMEN DELIVERED AT PAK EMIRATE MILITARY HOSPITAL, RAWALPINDI
title_fullStr	HISTOPATHOLOGICAL CHANGES IN PLACENTAL TISSUE OF COVID–19 PREGNANT WOMEN DELIVERED AT PAK EMIRATE MILITARY HOSPITAL, RAWALPINDI
title_full_unstemmed	HISTOPATHOLOGICAL CHANGES IN PLACENTAL TISSUE OF COVID–19 PREGNANT WOMEN DELIVERED AT PAK EMIRATE MILITARY HOSPITAL, RAWALPINDI
title_sort	histopathological changes in placental tissue of covid–19 pregnant women delivered at pak emirate military hospital, rawalpindi
publisher	Army Medical College Rawalpindi
publishDate	2020
url	https://doaj.org/article/1cb5ecc0a4eb47bc8c94e7ca70b47729
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HISTOPATHOLOGICAL CHANGES IN PLACENTAL TISSUE OF COVID–19 PREGNANT WOMEN DELIVERED AT PAK EMIRATE MILITARY HOSPITAL, RAWALPINDI

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